DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Phlpp and Chadl

DIOPT Version :9

Sequence 1:	NP_001260558.1	Gene:	Phlpp / 35178	FlyBaseID:	FBgn0032749	Length:	954	Species:	Drosophila melanogaster
Sequence 2:	XP_006520805.1	Gene:	Chadl / 214685	MGIID:	3036284	Length:	759	Species:	Mus musculus

Alignment Length:	391	Identity:	108/391 - (27%)
Similarity:	152/391 - (38%)	Gaps:	90/391 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   112 QTLVADHNYLH------NIS-TTNTHPVPLKLQRIDISHNNFSELPNWVGACASLTAINASHNRL 169
            ||.|.|::..|      |:: ..||  :|...||:|:..|....||    |.|.....:.:|..|
Mouse    45 QTCVCDNSRRHVTCRHQNLTEVPNT--IPELTQRLDLQGNILKVLP----AAAFQDLPHLTHLDL 103

  Fly   170 NNVAVLL---RNYR-ITELVSLDLAYNDLKQLDQFP-EGFSSIRSLQLQSNELPSL-PDNFFAVT 228
            .|..|.:   ..:| :..|:.|:||.|.|..|.|.. :|..|:|.|:|:.|.|..| |..|.|:
Mouse   104 RNCQVEMVAEGAFRGLGRLLLLNLASNRLSTLPQEALDGLGSLRRLELEGNMLEELRPGTFGAL- 167

  Fly   229 HARLETLNVSCNKLSTLPRYEQNNHAALVNLSLAGNHLNDSIFEPLHNAAKLRVLHLAYNRIGVL 293
             ..|.|||::.|.|..||             ::|        |:.|   .:.|.|.|::|.:.||
Mouse   168 -GSLTTLNLAHNALVYLP-------------AMA--------FQGL---LRTRWLQLSHNALSVL 207

  Fly   294 PAACVRNWPELEILVLSGNMLQQLPEEVATLGQLRV---LRCCNNLLLCTPQLAKLAM--LKVLD 353
            ....:...|.|..|.|..|.||.||.  |.|.|.|.   |...:|.|..|.:...||:  |:.|.
Mouse   208 APEALAGLPALRRLSLHHNELQALPG--AALSQARSLARLELGHNPLTYTGEEDGLALPGLRELA 270

  Fly   354 LSHNHLDRVNLLALVPSRNLKYLDLSGNL-----QLQVDEQQFKV----------CQSQSQRHWS 403
            |.|..|..:...|......|..|||.||.     .|||..|..::          |.::....|
Mouse   271 LDHGSLQALGPRAFAHCPRLHTLDLRGNQLTTLPPLQVPGQLRRLRLQGNPLWCACHARPLLEW- 334

  Fly   404 LVDVSGNNRAALPTTKIRQVSAQRNQNKTSGPW--TMGFAETPGSGDCRKLSVYQLRAANYGGSD 466
                       |...::|...|.|...:..|..  |:..::....||.         ||..|..|
Mouse   335 -----------LVRARVRSDGACRGPRRLRGEALDTLRPSDLRCPGDA---------AAGDGDGD 379

  Fly   467 E 467
            |
Mouse   380 E 380

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phlpp	NP_001260558.1	leucine-rich repeat	91..110	CDD:275380
		LRR_8	109..169	CDD:290566	18/63 (29%)
		leucine-rich repeat	111..135	CDD:275380	9/29 (31%)
		leucine-rich repeat	136..158	CDD:275380	7/21 (33%)
		leucine-rich repeat	159..183	CDD:275380	5/27 (19%)
		leucine-rich repeat	184..209	CDD:275380	10/25 (40%)
		LRR_8	205..266	CDD:290566	19/61 (31%)
		leucine-rich repeat	210..230	CDD:275380	8/20 (40%)
		leucine-rich repeat	232..255	CDD:275380	8/22 (36%)
		LRR_RI	<256..410	CDD:238064	46/173 (27%)
		leucine-rich repeat	256..276	CDD:275380	3/19 (16%)
		LRR_8	279..359	CDD:290566	29/84 (35%)
		leucine-rich repeat	280..303	CDD:275380	6/22 (27%)
		leucine-rich repeat	304..348	CDD:275380	17/46 (37%)
		leucine-rich repeat	349..372	CDD:275380	6/22 (27%)
		PP2Cc	461..655	CDD:294085	3/7 (43%)
Chadl	XP_006520805.1	PRK15370	<32..>322	CDD:185268	93/310 (30%)
		leucine-rich repeat	54..72	CDD:275380	4/19 (21%)
		leucine-rich repeat	74..97	CDD:275380	8/26 (31%)
		leucine-rich repeat	98..121	CDD:275380	5/22 (23%)
		leucine-rich repeat	122..145	CDD:275380	9/22 (41%)
		leucine-rich repeat	146..169	CDD:275380	9/24 (38%)
		LRR_8	169..228	CDD:338972	22/82 (27%)
		leucine-rich repeat	170..193	CDD:275380	11/46 (24%)
		leucine-rich repeat	194..217	CDD:275380	6/22 (27%)
		leucine-rich repeat	218..241	CDD:275380	11/24 (46%)
		leucine-rich repeat	242..265	CDD:275380	6/22 (27%)
		leucine-rich repeat	266..289	CDD:275380	6/22 (27%)
		leucine-rich repeat	312..351	CDD:275380	6/50 (12%)
		LRRNT	405..439	CDD:214470
		leucine-rich repeat	437..460	CDD:275380
		LRR_8	460..519	CDD:338972
		leucine-rich repeat	461..484	CDD:275380
		leucine-rich repeat	485..508	CDD:275380
		LRR	<507..>687	CDD:227223
		leucine-rich repeat	509..532	CDD:275380
		leucine-rich repeat	533..556	CDD:275380
		leucine-rich repeat	557..580	CDD:275380
		leucine-rich repeat	581..604	CDD:275380
		leucine-rich repeat	605..629	CDD:275380
		leucine-rich repeat	630..653	CDD:275380
		leucine-rich repeat	655..677	CDD:275380
		LRRCT	685..733	CDD:214507
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X32
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.000