DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Phlpp and Lrrc1

DIOPT Version :9

Sequence 1:	NP_001260558.1	Gene:	Phlpp / 35178	FlyBaseID:	FBgn0032749	Length:	954	Species:	Drosophila melanogaster
Sequence 2:	XP_030100078.1	Gene:	Lrrc1 / 214345	MGIID:	2442313	Length:	580	Species:	Mus musculus

Alignment Length:	428	Identity:	103/428 - (24%)
Similarity:	177/428 - (41%)	Gaps:	86/428 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    80 MEVLDLS---------SLAQLETLKCSRNKLMELIINGTNLQTLVADHNYLHNISTTNTH----- 130
            ::|.|.|         |..:|:.|.|       |.:|..:||:|..:...|:|:::....
Mouse   163 LQVADFSGNPLTRLPESFPELQNLTC-------LSVNDISLQSLPENIGNLYNLASLELRENLLT 220

  Fly   131 --PVPL----KLQRIDISHNNFSELPNWVGACASLTAINASHNRLNNVAVLLRNYRITELVSLDL 189
              |..|    :|:.:|:.:|....||..:||...|..:....|:|:.:...:.|  :..|:.||:
Mouse   221 YLPDSLTQLRRLEELDLGNNEIYNLPESIGALLHLKDLWLDGNQLSELPQEIGN--LKNLLCLDV 283

  Fly   190 AYNDLKQLDQFPEGFSSIRSLQLQSNELPSLPDNFFAVTHARLETLNVSCNKLSTLPRY--EQNN 252
            :.|.|::|.:...|.:|:..|.:..|.|.::|:....:  .:|..|.:..|:|:.||..  :..|
Mouse   284 SENRLERLPEEISGLTSLTYLVISQNLLETIPEGIGKL--KKLSILKLDQNRLTQLPEAIGDCEN 346

  Fly   253 HAALVNLSLAGNHLNDSIFEPLHNAAKLRVLHLAYNRIGVLP---AACVRNWPELEILVLSGNML 314
               |..|.|..|.|. ::.:.:....||..|:...|::..||   ..|.    .|.:..:..|.|
Mouse   347 ---LTELVLTENRLL-TLPKSIGKLKKLSNLNADRNKLVSLPKEIGGCC----SLTMFCIRDNRL 403

  Fly   315 QQLPEEVATLGQLRVLRCCNNLLLCTPQLAKLAMLKVLDLSHNH----------LDRVN------ 363
            .:||.||:...:|.||....|.|...|.......||.|.||.|.          :||..
Mouse   404 TRLPAEVSQAVELHVLDVAGNRLHHLPLSLTTLKLKALWLSDNQSQPLLTFQTDIDRATGEKILT 468

  Fly   364 --LLALVPSRNL--KYLDLSGNLQLQVDEQQFKVCQSQSQRHWSLVDVSGNNRAALPTTKIRQVS 424
              ||..:||..:  :.|...|.|:..|.:        .|:..|       |:|:....:.||.:.
Mouse   469 CVLLPQMPSEPICQESLPRCGALESLVTD--------MSEEAW-------NDRSVHRVSAIRFLE 518

  Fly   425 AQR--NQNKTSGPWTMGFAETPGSGDCR--KLSVYQLR 458
            .::  ::|:|.   |:....||..|:.:  |.:|..||
Mouse   519 DEKDEDENETR---TLQRRATPHPGELKNMKKTVENLR 553

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phlpp	NP_001260558.1	leucine-rich repeat	91..110	CDD:275380	5/18 (28%)
		LRR_8	109..169	CDD:290566	16/70 (23%)
		leucine-rich repeat	111..135	CDD:275380	7/34 (21%)
		leucine-rich repeat	136..158	CDD:275380	7/21 (33%)
		leucine-rich repeat	159..183	CDD:275380	4/23 (17%)
		leucine-rich repeat	184..209	CDD:275380	8/24 (33%)
		LRR_8	205..266	CDD:290566	16/62 (26%)
		leucine-rich repeat	210..230	CDD:275380	4/19 (21%)
		leucine-rich repeat	232..255	CDD:275380	7/24 (29%)
		LRR_RI	<256..410	CDD:238064	43/176 (24%)
		leucine-rich repeat	256..276	CDD:275380	5/19 (26%)
		LRR_8	279..359	CDD:290566	26/92 (28%)
		leucine-rich repeat	280..303	CDD:275380	6/25 (24%)
		leucine-rich repeat	304..348	CDD:275380	13/43 (30%)
		leucine-rich repeat	349..372	CDD:275380	12/40 (30%)
		PP2Cc	461..655	CDD:294085
Lrrc1	XP_030100078.1	PRK12323	<4..>158	CDD:237057
		LRR	146..446	CDD:227223	76/301 (25%)
		leucine-rich repeat	163..185	CDD:275380	5/21 (24%)
		leucine-rich repeat	186..208	CDD:275380	8/28 (29%)
		leucine-rich repeat	209..231	CDD:275380	2/21 (10%)
		leucine-rich repeat	232..254	CDD:275380	7/21 (33%)
		leucine-rich repeat	255..277	CDD:275380	4/23 (17%)
		leucine-rich repeat	278..300	CDD:275380	7/21 (33%)
		leucine-rich repeat	301..346	CDD:275380	10/46 (22%)
		leucine-rich repeat	347..369	CDD:275380	5/22 (23%)
		leucine-rich repeat	370..392	CDD:275380	6/25 (24%)
		leucine-rich repeat	416..437	CDD:275380	6/20 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910