DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Phlpp and gcy-36

DIOPT Version :9

Sequence 1:	NP_001260558.1	Gene:	Phlpp / 35178	FlyBaseID:	FBgn0032749	Length:	954	Species:	Drosophila melanogaster
Sequence 2:	NP_510557.3	Gene:	gcy-36 / 191657	WormBaseID:	WBGene00001556	Length:	675	Species:	Caenorhabditis elegans

Alignment Length:	166	Identity:	43/166 - (25%)
Similarity:	68/166 - (40%)	Gaps:	45/166 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   536 APSKVRPLKSKRYVLRMASTGGLDAYLIRRTSQLRLTKPDVIQKD-QIHSMP--DPHVLELILSN 597
            |.|:.:.||.|..::.| |:||...||   .|....:.|:::|.. ::.:||  || ..:|||.|
Worm   326 ALSQSQHLKLKGQMMLM-SSGGHIMYL---CSPYVTSIPELLQYGLRLTAMPIHDP-TRDLILLN 385

  Fly   598 DDE--------YLVVGNAQLWSVMDIDRAAREIRKEE---NSLLAAKRLVDIAQSFAAAESLSV- 650
            ...        .|...|.||      :..|:::..|:   ::||.......:||..  .:.|||
Worm   386 QQRLSDVEMNLQLEANNEQL------ENMAKDLEVEKGKTDALLREMLPPSVAQQL--KQGLSVE 442

  Fly   651 ------IVVRFRHLGT-----------DVDHLIREL 669
                  ..|.|..:.|           |:.||:.||
Worm   443 AREYEEATVMFTDVPTFQQIVPLCTPKDIVHLLNEL 478

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phlpp	NP_001260558.1	leucine-rich repeat	91..110	CDD:275380
		LRR_8	109..169	CDD:290566
		leucine-rich repeat	111..135	CDD:275380
		leucine-rich repeat	136..158	CDD:275380
		leucine-rich repeat	159..183	CDD:275380
		leucine-rich repeat	184..209	CDD:275380
		LRR_8	205..266	CDD:290566
		leucine-rich repeat	210..230	CDD:275380
		leucine-rich repeat	232..255	CDD:275380
		LRR_RI	<256..410	CDD:238064
		leucine-rich repeat	256..276	CDD:275380
		LRR_8	279..359	CDD:290566
		leucine-rich repeat	280..303	CDD:275380
		leucine-rich repeat	304..348	CDD:275380
		leucine-rich repeat	349..372	CDD:275380
		PP2Cc	461..655	CDD:294085	36/139 (26%)
gcy-36	NP_510557.3	HNOB	3..167	CDD:285002
		HNOBA	217..435	CDD:285003	32/119 (27%)
		CYCc	415..604	CDD:214485	16/66 (24%)
		Guanylate_cyc	441..624	CDD:278633	9/38 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900