DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Phlpp and gcy-25

DIOPT Version :9

Sequence 1:	NP_001260558.1	Gene:	Phlpp / 35178	FlyBaseID:	FBgn0032749	Length:	954	Species:	Drosophila melanogaster
Sequence 2:	NP_001294116.1	Gene:	gcy-25 / 191653	WormBaseID:	WBGene00001549	Length:	1034	Species:	Caenorhabditis elegans

Alignment Length:	976	Identity:	175/976 - (17%)
Similarity:	310/976 - (31%)	Gaps:	354/976 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 LKVSASHSGPHPLPVEVTAAEEEQAATFGQTSPQKLSLKGSQLGGSILIGNYNYLTQLEVCENEM 80
            |:.:|:.:..:.:.:.:.||.:|:..|.     .:|:|:..:|          ||:...:...|.
Worm    60 LENAANLNYQYSVDLLIGAACDEETQTV-----SRLALRWHKL----------YLSSAPLSTKEK 109

  Fly    81 EVL-------DLSSLAQLETLKCSRNKLMELIINGTNLQTLVADHNYLHNISTTNT-HPV--PLK 135
            |..       .|:..|::....|...|..|:.|              :::..|..| |.:  .|.
Worm   110 ESTTIALKPHSLAGTAEVILAMCKSMKWKEIGI--------------IYSEETKYTAHAIYDMLA 160

  Fly   136 LQRIDISHNNFSELPNWVGACASLTAINASHNRLNNVAVLLRNYR--ITELVSLDLA--YNDLKQ 196
            .|..|:..|.|.|.                 :.|:|...:|.:.|  |:.|.:|||:  :..||:
Worm   161 EQEDDLKINVFLET-----------------DGLSNTYTILHSARALISFLTTLDLSKFFKTLKE 208

  Fly   197 LDQFPEGFSSIRSLQLQSNELPSLPDNFFAVTHARLETLNVSCNK--LSTLPRYEQNNHAALVNL 259
                    ::.|.|:             |::.|       |.|||  :|....|..||
Worm   209 --------NAFRPLE-------------FSIVH-------VDCNKSEISNFYTYLDNN------- 238

  Fly   260 SLAGNHLNDSIFEPLHNAAKLRVLHLAYNRIGVLPAACVRNWPELEILVLSGNMLQQLPEEVATL 324
              ||...|     |: :||:||.|   |..:.:|     :|         |.:.:::..|.....
Worm   239 --AGEEPN-----PI-SAARLRKL---YRHVALL-----KN---------SHDDMEKTEEFAKKY 278

  Fly   325 GQLRVLRCCNNLLLC---------TPQLAKLAMLKVLDLSHNHLDRVNLLALVPSRNLKYLDLSG 380
            |.:........|:||         |.....|::::.|....||:           .|.:....||
Worm   279 GLVPSYTLYKALILCDGLQLLNNYTAPRGNLSIVQQLPYLWNHV-----------TNTETQGYSG 332

  Fly   381 NLQLQVDEQQFKVCQSQSQRHWSLV----------DVSGNNRAA-----LPTTKIRQ-------- 422
            .:.:..|..:....:....|....|          |..|.|...     ||::.:.:
Worm   333 PVFIGNDGVRLPYYEMHMWRDGKAVHVANVKPRESDYCGGNMTKNCYEFLPSSPLLEDLPPYTSD 397

  Fly   423 ---------------VSA----------------QRNQNKTSG-PW-----TMGFAETPGS-GDC 449
                           ::|                ||.::.... ||     ::.|.:..|| ...
Worm   398 CGYDNNLCSDFHVFMIAAIVFSILLIPMAIAFYLQRKEHLIQQMPWRVPLDSISFDDNGGSLSAS 462

  Fly   450 RKLSVYQLRAANYGGSDEALYGMFEALEGRGRAAQEMSHLVPDLMKQEQMVKDSAVRDYMKFTLL 514
            |::|......|:|.       .:|.     |..|:   |.:  :.||:..||....|..:.|
Worm   463 RRVSTISTARASYS-------SIFS-----GNVAE---HAI--VNKQKVSVKRHVQRRAITF--- 507

  Fly   515 AAQQQCGSVRSAALFHLTRTRAPSKVRPLK----------------SKRYVLRMASTGGLDAYLI 563
                   |.:...:.:..:..:.:.:.|..                :.||.|.       |...:
Worm   508 -------SRQEMEMLNQLKYMSHTNINPFTGICFNQGSELIVMWQFTTRYSLE-------DLIFV 558

  Fly   564 R-----RTSQLRLTKPDVIQKDQIHSMPDPHVLELILSN--DDEYLVVGNAQLWSVMDIDRAARE 621
            :     |..|....|..|...:.||:........|.|||  .|.|        |.|...|...:.
Worm   559 KEQKFGRNFQSTFIKHIVHGINYIHNSSIKVHGALYLSNCVVDSY--------WVVKLTDFGIKG 615

  Fly   622 IRKEENSLLAAKRLVDIAQSFAAAESLSVIVVRFRHLGTDVDHLIRELKQSVRKKPQPVSLPLSS 686
            |.||..:          .:..|.:.:..|..:.:::|....:|:...|:    |..:|..  ...
Worm   616 ILKERTN----------HKELAPSSAFDVDAIHYKYLQLAPEHISAILE----KLEEPRG--TVE 664

  Fly   687 GSVCKRTCCDRSNACRHRAIEQ-----EPLAGRSSP--------SGQSDRDLLAK-DKDDEFVLA 737
            |.:.:...|          |.|     .|.|.|...        |.||...|..| .:.:.|.:.
Worm   665 GDIYQLAMC----------IYQILFYMRPFAERQESIKELAHLLSSQSTAPLHPKVPEGNSFTMR 719

  Fly   738 HARVLQE--------------------------------EQQLEMLDETESVSESVLSEEQFKCW 770
            ...::|:                                :|.:||:||..:..|.:::|...:
Worm   720 LLSIIQQCWLYKPAARPALIKITDAVNREFGQDVKGTLIDQMIEMIDEYSANLEQIVAERTRE-- 782

  Fly   771 EYMLEQNTQLLFDKELNTISKSFTKQRTVPNAIMAA-TVLPERNDFTSNLMRTVT--NKFISTST 832
               |||:..:..:.....:.||      |.::|.:. ||:||::...:.|:..|.  .||.....
Worm   783 ---LEQDMSVTENLLYQLLPKS------VADSIRSGKTVVPEQHSSVTLLVVDVCQFTKFCEAFI 838

  Fly   833 P 833
            |
Worm   839 P 839

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phlpp	NP_001260558.1	leucine-rich repeat	91..110	CDD:275380	4/18 (22%)
		LRR_8	109..169	CDD:290566	9/62 (15%)
		leucine-rich repeat	111..135	CDD:275380	3/26 (12%)
		leucine-rich repeat	136..158	CDD:275380	5/21 (24%)
		leucine-rich repeat	159..183	CDD:275380	5/25 (20%)
		leucine-rich repeat	184..209	CDD:275380	6/26 (23%)
		LRR_8	205..266	CDD:290566	14/62 (23%)
		leucine-rich repeat	210..230	CDD:275380	2/19 (11%)
		leucine-rich repeat	232..255	CDD:275380	8/24 (33%)
		LRR_RI	<256..410	CDD:238064	30/172 (17%)
		leucine-rich repeat	256..276	CDD:275380	4/19 (21%)
		LRR_8	279..359	CDD:290566	16/88 (18%)
		leucine-rich repeat	280..303	CDD:275380	6/22 (27%)
		leucine-rich repeat	304..348	CDD:275380	8/52 (15%)
		leucine-rich repeat	349..372	CDD:275380	3/22 (14%)
		PP2Cc	461..655	CDD:294085	37/216 (17%)
gcy-25	NP_001294116.1	PBP1_iGluR_N_LIVBP_like	56..>230	CDD:107346	47/243 (19%)
		PKc_like	473..746	CDD:304357	57/340 (17%)
		SPS1	474..>736	CDD:223589	56/329 (17%)
		HNOBA	<764..805	CDD:285003	11/51 (22%)
		CYCc	790..976	CDD:214485	13/56 (23%)
		Nucleotidyl_cyc_III	812..999	CDD:299850	8/28 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900