DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Phlpp and gcy-23

DIOPT Version :9

Sequence 1:	NP_001260558.1	Gene:	Phlpp / 35178	FlyBaseID:	FBgn0032749	Length:	954	Species:	Drosophila melanogaster
Sequence 2:	NP_500309.3	Gene:	gcy-23 / 191652	WormBaseID:	WBGene00001548	Length:	1073	Species:	Caenorhabditis elegans

Alignment Length:	1004	Identity:	163/1004 - (16%)
Similarity:	292/1004 - (29%)	Gaps:	424/1004 - (42%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 ATFGQTSPQKLSLKGSQL-------------------GGSILIGNY--------------NYLTQ 72
            ||..:|..:...|.|.::                   .|::::.:.              |..|.
Worm   333 ATMNETGNENSYLNGKEVWNHMRRITFPGLVSNAGVTSGTVMMDDIAERAPVYAAFYVPPNSDTV 397

  Fly    73 LEVCE------------------NEMEVLDLS---------SLAQLETLKCSRNKLME---LIIN 107
            .:|||                  .|::|.|||         ||...|.....||:..:   |||.
Worm   398 RKVCELEPVMLTNCDGTKTGNGCYELQVTDLSTGFWPSIDGSLPADEPACGFRNEKCDYTTLIIG 462

  Fly   108 GTNLQTLV-------ADHNYLHNISTTNTHPVPLKLQRIDISHNNFSELPNWVGACASLTAINAS 165
            |..:..::       .......|.:..||   |.::.|.|......:|:       .|:.:|.:|
Worm   463 GCIVLLIILLIICFFILSRVCENRALANT---PWRIYRDDFRTIQENEM-------KSMLSIGSS 517

  Fly   166 HNRLNNVAVLLRNYRITELVSLDLAYNDLKQLDQFPEGFSSI---RSLQLQSNELPSLPDN---F 224
            ..:::|:::.::::.:       :..|.......:|:....:   :.|||.:....::.||   |
Worm   518 KTKMSNMSMFVKHHAV-------VGTNTHASFHLYPQRRPIVFNRQDLQLLNQMKQAVHDNLNPF 575

  Fly   225 FAVTHARLETLNV---SCNKLSTLPRYEQNN--------HAALV-NLSLAGNHLNDSIFEPLHNA 277
            ..::....|.:.|   .|:: .|:.....|.        |.|.: :::|...:|:.||
Worm   576 LGMSFNEKEEMVVLWKFCSR-GTIQDMIYNQEVSLDSKFHGAFIRDITLGLEYLHSSI------- 632

  Fly   278 AKLRVLHLAYNRIGVLPAACV--RNWPELEILVLSGNMLQQLPEEVATLGQLRVLRCCNNLLLCT 340
                   :.|:. .:.|.:|:  |||
Worm   633 -------IGYHG-SLTPWSCLIDRNW--------------------------------------- 650

  Fly   341 PQLAKLAMLKVLDLS-HNHLDRVNLLALVPSRNLKYLDLSGNLQLQVDEQQFKVCQSQSQRHWSL 404
                   |:|:.|.. .|.|:|...|.|:.:..||..|
Worm   651 -------MIKLTDYGIANPLERWEKLGLISTETLKEGD--------------------------- 681

  Fly   405 VDVSGNNRAALPTTKIRQVSAQRNQNKTSGPWTMGFAETPGSGDCRKLSVYQLRAANYGGSDEAL 469
             |.||              |||    |||                                  .|
Worm   682 -DKSG--------------SAQ----KTS----------------------------------LL 693

  Fly   470 YGMFEALEGRGRAAQEMSHLVPDLMKQEQMVKDSAVRDYMKFTLLAAQQQCGSVRSAALFHLTRT 534
            |...|.|  :.:.:.....:....:||.|                 |::|.|.:.:   |.:...
Worm   694 YQPPEML--KNKESNRTRRMDQSWVKQSQ-----------------ARRQMGDIYA---FGMVMH 736

  Fly   535 RAPSKVRPLKSKRYVLRMASTGGLDAYLIRRTSQLRLTKPDVIQKDQIHSMPDPHVLELILSNDD 599
            ....:..|..:...|..:..      |:...|...|   |.|..:.|||    |.::.|:|
Worm   737 EILFRALPFPNGTNVSEVMD------YIRDGTKTFR---PTVHDRTQIH----PDLVALLL---- 784

  Fly   600 EYLVVGNAQLWSV-MDIDRAAREIRKEENSLLAAKRLVDIAQSFAAAESLSVIVVRFRHLGTDVD 663
                    ..|:. .::..:.|.:|....:.|..|                         |:.||
Worm   785 --------DCWNENPEVRPSIRRVRLNTENYLKVK-------------------------GSLVD 816

  Fly   664 HLIRELKQSVRKKPQPVSLPLSSGSVCKRT-CCDRSNACRHRAIEQ--------EPLAGRSSPSG 719
            .::|.::|......:         .|.:|| ..:.:|....:.:.|        |...|||.|:.
Worm   817 QMMRMMEQYANNLEK---------LVAERTGMLEEANVRADKLLGQLLPKYVANELKMGRSVPAK 872

  Fly   720 QSD-RDLLAKDKDDEFVLAHARVLQEEQQLEMLDETESVSESVLSEEQFKCWEYMLEQNTQLLFD 783
            ..| ..::..|     ::....:......||::    |:..|:.|:                 ||
Worm   873 TFDMATVMFSD-----IVGFTTICSSSTPLEVV----SMLNSIYSK-----------------FD 911

  Fly   784 KELNTISKSFTKQRTVPNAIMAATVLPER--NDFTSNLMRTVTNKFISTSTPQLP--QPITTSVP 844
            ..:|  .....|..|:.:|.|..:.:||.  |:...|:..|.....:...|.::|  :.:...:.
Worm   912 DAIN--KHGSYKVETIGDAYMIVSGIPEENGNEHIRNICNTALELMLLLKTYEIPHRRNVKLRIR 974

  Fly   845 LGSYHQVKQAPPGHFGSALSFQQAHSYGYNLFDAKPRPKFHGGTVKRSAG------PNSAYFGSL 903
            ||                                     .|.|||  :||      |....||.
Worm   975 LG-------------------------------------IHTGTV--AAGVVGLTAPRYCLFGD- 999

  Fly   904 QRLMPYNFEYDFAVTQERERNILDEEEHD 932
                ..|.......|.|.|:..:.:|..|
Worm  1000 ----TVNVASRMESTSEPEKIQMSQEARD 1024

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phlpp	NP_001260558.1	leucine-rich repeat	91..110	CDD:275380	7/21 (33%)
		LRR_8	109..169	CDD:290566	10/66 (15%)
		leucine-rich repeat	111..135	CDD:275380	4/30 (13%)
		leucine-rich repeat	136..158	CDD:275380	3/21 (14%)
		leucine-rich repeat	159..183	CDD:275380	3/23 (13%)
		leucine-rich repeat	184..209	CDD:275380	2/27 (7%)
		LRR_8	205..266	CDD:290566	14/78 (18%)
		leucine-rich repeat	210..230	CDD:275380	6/22 (27%)
		leucine-rich repeat	232..255	CDD:275380	6/33 (18%)
		LRR_RI	<256..410	CDD:238064	23/157 (15%)
		leucine-rich repeat	256..276	CDD:275380	4/20 (20%)
		LRR_8	279..359	CDD:290566	10/82 (12%)
		leucine-rich repeat	280..303	CDD:275380	6/24 (25%)
		leucine-rich repeat	304..348	CDD:275380	0/43 (0%)
		leucine-rich repeat	349..372	CDD:275380	7/23 (30%)
		PP2Cc	461..655	CDD:294085	29/194 (15%)
gcy-23	NP_500309.3	Periplasmic_Binding_Protein_Type_1	38..407	CDD:299141	11/73 (15%)
		ANF_receptor	38..385	CDD:279440	6/51 (12%)
		PK_GC	509..806	CDD:270894	76/492 (15%)
		HNOBA	<817..863	CDD:285003	7/54 (13%)
		CYCc	842..1035	CDD:214485	45/255 (18%)
		Guanylate_cyc	869..1056	CDD:278633	39/228 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900