DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Phlpp and gcy-17

DIOPT Version :9

Sequence 1:	NP_001260558.1	Gene:	Phlpp / 35178	FlyBaseID:	FBgn0032749	Length:	954	Species:	Drosophila melanogaster
Sequence 2:	NP_001293327.1	Gene:	gcy-17 / 191649	WormBaseID:	WBGene00001542	Length:	1088	Species:	Caenorhabditis elegans

Alignment Length:	699	Identity:	128/699 - (18%)
Similarity:	252/699 - (36%)	Gaps:	183/699 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 LKATRKQADPYKSKLKVSASHSGPHPLPVEVTAAEEEQAATFGQTSPQKLSLKGSQLGGSILIGN 66
            ::..||:.:.......|.|||..|.....:..|::...|:  |.::..||:::........:...
Worm   504 IRQKRKEIERQDELWHVEASHLKPISKKSKSEASQRSFAS--GPSTSTKLTVESRTETTRFIFYI 566

  Fly    67 YNYLTQLEVCEN------EMEVLDLSSLAQLETLKCSR-NKLMELIINGTNLQTLVADHNYLHNI 124
            |.......|..|      ::..::.|.|.|:.:|.... ||.:.|.:|.   |.|::...|....
Worm   567 YQVRNNEVVAANKHDFRPQLTDVERSELRQMRSLDHDNLNKFIGLCLNS---QQLLSIWRYCSRG 628

  Fly   125 STTNTHPVPLKLQRIDISHNNF------SELPNWVGACASLTAINASHNRLNNVAVLLRNYRITE 183
            |..:.      :.|..:..::|      .::.|.:|...  |::...|..|::.:.|:.: |...
Worm   629 SLADV------ISRSSMQMDSFFMLSLIRDIANGLGFIH--TSMLHFHGYLSSRSCLIDD-RWQV 684

  Fly   184 LVSLDLAYNDLKQLDQF---------PEGFSSIRSLQLQSNELPSLPDNFFAVTHARLETLNVSC 239
            .:| |...|:::.:|:.         ||   .:|.|:.:|.|             |.:.:..:.|
Worm   685 KIS-DFGLNEVRGMDKLSTENMLWWAPE---VLRGLEQRSKE-------------ADIYSFGIIC 732

  Fly   240 NKLST------LPRYEQNNHAALVNLSLAG-NHLNDSIF--EPLH-NAAKLRVLHLAYNRIGVLP 294
            :::.|      |...::.....:..|...| |.:..|:.  |.|. |.|   ::||
Worm   733 SEVITRSSAFDLENRKEKPEEIIYQLKKGGFNAIRPSLLTDEALEINPA---LVHL--------- 785

  Fly   295 AACVRN-WPELEILVLSGNMLQQLPEEVATLGQLR-VLRCCNNLLLCTPQLAKLAMLKVLDLSHN 357
               :|: |.|             .|.|...:.|:| :||..|:                 ....|
Worm   786 ---IRDCWTE-------------KPSERPPIDQVRSLLRGMND-----------------GKKGN 817

  Fly   358 HLDRV-NLLALVPSRNLKYLDLSGNLQLQVDEQQFKVCQSQSQRHWSLVDVSGNNRAALPTTKIR 421
            .:|.| |:|....|          .|:.:|:|:..::.:.|.:....|..:       ||.|...
Worm   818 LMDHVFNMLETYAS----------TLEEEVNERTKELVEEQKKSDVLLYRM-------LPKTVAE 865

  Fly   422 QVSAQRN-QNKTSGPWTMGFAE----TPGSGDCRKLSVYQLRAANYGGSDEALYGMFEALEGRGR 481
            ::.|..: :.:|....|:.|::    |..:..|..|.|.||.        ..||.:|::
Worm   866 KLKAGISIEPETFELVTIFFSDVVQFTTLASKCTPLQVVQLL--------NDLYTIFDS------ 916

  Fly   482 AAQEMSHLVPDLMKQEQMVKDSAVRD-YMKFTLLAAQQQCGSVRSAALFHLT--RTRAPSKVRPL 543
                       :::|..:.|...:.| |:..:.|..:.....::..|...|.  .:.|..:|..:
Worm   917 -----------IIEQNDVYKVETIGDGYLCVSGLPHRNGHDHIKHIARMSLAFLSSLAEFRVAHM 970

  Fly   544 KSKRYVLRMA-STGGLDAYLIRRTSQLRLTKPDVI----------QKDQIH-SMPDPHVLELIL- 595
            .|:|..||:. :.|.:.|.::..|........|.:          :..:|| |....|:|..::
Worm   971 PSERINLRIGINCGSVVAGVVGLTMPRYCLFGDAVNTASRMESNGKPGRIHVSSEANHLLTHVVG 1035

  Fly   596 ----SNDDEYLVVGNAQL---WSVMDIDR--AAREIRKEENSLLAAKRL 635
                ....|.::.|...:   |.:.:.|.  ....:||.||:...|:.:
Worm  1036 GFRTEERGEVIIKGKGVMNTYWLLGENDSVPVKSNMRKRENTPSMARSI 1084

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phlpp	NP_001260558.1	leucine-rich repeat	91..110	CDD:275380	5/19 (26%)
		LRR_8	109..169	CDD:290566	10/65 (15%)
		leucine-rich repeat	111..135	CDD:275380	4/23 (17%)
		leucine-rich repeat	136..158	CDD:275380	4/27 (15%)
		leucine-rich repeat	159..183	CDD:275380	5/23 (22%)
		leucine-rich repeat	184..209	CDD:275380	6/33 (18%)
		LRR_8	205..266	CDD:290566	11/67 (16%)
		leucine-rich repeat	210..230	CDD:275380	3/19 (16%)
		leucine-rich repeat	232..255	CDD:275380	3/28 (11%)
		LRR_RI	<256..410	CDD:238064	31/160 (19%)
		leucine-rich repeat	256..276	CDD:275380	6/23 (26%)
		LRR_8	279..359	CDD:290566	13/81 (16%)
		leucine-rich repeat	280..303	CDD:275380	4/23 (17%)
		leucine-rich repeat	304..348	CDD:275380	7/44 (16%)
		leucine-rich repeat	349..372	CDD:275380	6/23 (26%)
		PP2Cc	461..655	CDD:294085	34/200 (17%)
gcy-17	NP_001293327.1	Periplasmic_Binding_Protein_Type_1	25..404	CDD:299141
		ANF_receptor	47..398	CDD:279440
		PKc_like	539..808	CDD:304357	59/327 (18%)
		Pkinase	567..803	CDD:278497	53/292 (18%)
		HNOBA	<824..867	CDD:285003	11/59 (19%)
		CYCc	846..1038	CDD:214485	40/223 (18%)
		Guanylate_cyc	873..1060	CDD:278633	37/211 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900