DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Phlpp and gcy-15

DIOPT Version :9

Sequence 1:	NP_001260558.1	Gene:	Phlpp / 35178	FlyBaseID:	FBgn0032749	Length:	954	Species:	Drosophila melanogaster
Sequence 2:	NP_001364713.1	Gene:	gcy-15 / 191648	WormBaseID:	WBGene00001541	Length:	1104	Species:	Caenorhabditis elegans

Alignment Length:	1000	Identity:	168/1000 - (16%)
Similarity:	320/1000 - (32%)	Gaps:	371/1000 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   102 MELIINGTNLQTLVADHNYLHNISTTNTHPVPLKLQRIDISHN---NFSELPNWVGACASLTAIN 163
            ||:.||..|     ||.:                   :::.|:   |:.:.....|..|:.||
Worm     1 MEIAINRLN-----ADKD-------------------LEVFHDLDVNYVDTSKTAGPRAARTA-- 39

  Fly   164 ASHNRLNNVAV----LLRNYRITEL---VSLDLAYNDLKQLDQFPEGFSSIRS-------LQLQS 214
                .|||..|    |:|:..|...   ::|.:|.:|:.::|     .||::.       :..|:
Worm    40 ----ALNNATVAAMGLMRDCYIQSTILNINLKIAVSDVCEMD-----LSSVKGFDQTSVLMNSQT 95

  Fly   215 NEL--------------------PSLPDNFFA------------------VTHARLETLN----- 236
            |.|                    ||.....||                  :..:||:.::
Worm    96 NSLAKSVMYFLDKYQWKKVALVSPSAVLTAFAARVRSDLLDALTANKIDILVDSRLDPMSDITEK 160

  Fly   237 -----------VSCN-------------KLSTLPRYEQNNHAALVNLS----------------- 260
                       :.|:             ||..:.:.:...:..|..:|
Worm   161 VKEDAEKARIFIICDWSSNANLLRNYIFKLGEMNKMQSGEYFVLGYISYDTNYQWLEASSGDQRL 225

  Fly   261 --LAGNHLNDSIFEPLHNAAKLRVLHLAYNRIGVL-----PAACVRNWPELEILVLSGNMLQQLP 318
              |..:.:||      :|..: ..||..|..:.:|     ||.....|.:::..||.....:..|
Worm   226 VHLGASDIND------YNLTE-NDLHEVYKNVVILSDGPPPAEPNSTWEDIKTQVLKKKPAKMCP 283

  Fly   319 EEVATLGQLRVLRCCNNLL--LCTPQLAKLAML--KVLDLSHNHLDRVNLLALVPSRNL------ 373
            .            .||..:  ..||:..::.:|  .:..|:....|.:|:.|.:...::
Worm   284 P------------YCNTTISEKITPRWDRIKLLFDSIQYLADATNDALNIGANIYQSDIFYEHLI 336

  Fly   374 -----------KYLD----LSGNLQLQV-------DEQQFKVCQSQSQRH-----WSLVDVSGN- 410
                       :|:|    :.|::|:..       :......|...:|..     |||.|.|..
Worm   337 SRKVDSVTGVTEYIDGYGAIVGSMQIYYHFSSSSHNSYSLFPCARLAQSSLLNTVWSLTDYSEGL 401

  Fly   411 -----NRAALPTTKIRQVSAQRNQNKTSGP---------WTMGFAETPGSGDCRKLSVYQLRAAN 461
                 |::|...|.:...     ..:..||         .::|.|...|....   :.:..:...
Worm   402 SIDFVNKSAPKDTPVCGF-----YGENCGPPANNTFIIVISVGVAVLIGLAIA---AAFLYKRYR 458

  Fly   462 YGGSDEALYGMFEALEGR------------GRAAQEMSHLVPDLMKQEQMVKDS--AVRDYMKFT 512
            |   :..|:.:|..::..            .::.:.|:.:...::...|.::||  .:.||
Worm   459 Y---ERRLHSLFFMIDRNQIILKKHTNLMSQQSLRSMASIHGSVVAASQTLRDSHFFIEDY---- 516

  Fly   513 LLAAQQQCGSVRSAALFHLTRTRAPSKVRPLKSKRYVLRMASTG-------------GLDAYLIR 564
                 ....|:.::::|:...|.......|:.....|     ||             |:..|..|
Worm   517 -----NNASSINASSIFNTGSTARAGPFGPIPGFGGV-----TGASEDEKWHQIPDFGVGLYEGR 571

  Fly   565 RTSQLRLTKPDV-------IQKDQIHSMPDPHVLE---LILSNDDEYLVVGNAQLWSVMDI---- 615
            ..:..|:.:.||       ::..::....:.:|:|   :::.:.|.::|...||..|:.||
Worm   572 TVALKRIYRSDVEFTRSNRLEIAKLQESVNSNVIEFVGMVVQSPDVFVVYELAQRGSLKDILDND 636

  Fly   616 ---------DRAAREI-----------------RKEENSLLAAKRLVDIAQSFAAAESLSVIVVR 654
                     .:..::|                 .|..|.|:.|:.:|.:: ||...|      :|
Worm   637 DMPLDDVFRSQMTKDIIAGLEYLHSSPVGCHGRLKSTNCLIDARWMVRLS-SFGLRE------LR 694

  Fly   655 FRHLGTDVDHLIRELKQSVRKKPQPVSLPLSSG-SVCKRTCCDRSNACRHRAIEQEPLAGRSSPS 718
            ........|. ::|.|..:...|:  .|..|:| |.|......:|:. ...||....|.||..|.
Worm   695 GEETWQQEDD-VQEGKDQLWTSPE--LLRWSTGLSQCGVLLVQKSDV-YSLAIVLYELFGRLGPW 755

  Fly   719 GQS-----------DRDLLAKDKDDEFVLAHARVLQEEQQLEMLDETESVSESVLSEEQFKCWEY 772
            |..           .|:.||..|.....:|   ||:|..::        |.|:|::     .|.
Worm   756 GDEPMEPREIVSLVKREALAGKKPFRPDMA---VLKESPRI--------VQETVVA-----AWT- 803

  Fly   773 MLEQNTQLLFDKELNTISKSFTKQRTVPNAI-MAATVLPER----NDFTSNLMRTVT--NKFIST 830
                      :..||..|....|::..|..| :..|::...    ..:|..|.:.:.  |:.:..
Worm   804 ----------EDPLNRPSLHQIKRKLKPLTIGLKRTIMDNMVSMIEKYTDKLEKDIAERNEELEA 858

  Fly   831 STPQ--------LPQPITTSVPLGS 847
            ...:        ||:.:..|:.|||
Worm   859 EKAKSEALLKMMLPEVVADSLKLGS 883

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phlpp	NP_001260558.1	leucine-rich repeat	91..110	CDD:275380	4/7 (57%)
		LRR_8	109..169	CDD:290566	9/62 (15%)
		leucine-rich repeat	111..135	CDD:275380	2/23 (9%)
		leucine-rich repeat	136..158	CDD:275380	3/24 (13%)
		leucine-rich repeat	159..183	CDD:275380	9/27 (33%)
		leucine-rich repeat	184..209	CDD:275380	6/27 (22%)
		LRR_8	205..266	CDD:290566	17/153 (11%)
		leucine-rich repeat	210..230	CDD:275380	7/57 (12%)
		leucine-rich repeat	232..255	CDD:275380	4/51 (8%)
		LRR_RI	<256..410	CDD:238064	36/214 (17%)
		leucine-rich repeat	256..276	CDD:275380	5/38 (13%)
		LRR_8	279..359	CDD:290566	16/88 (18%)
		leucine-rich repeat	280..303	CDD:275380	7/27 (26%)
		leucine-rich repeat	304..348	CDD:275380	7/45 (16%)
		leucine-rich repeat	349..372	CDD:275380	5/24 (21%)
		PP2Cc	461..655	CDD:294085	40/260 (15%)
gcy-15	NP_001364713.1	Periplasmic_Binding_Protein_type1	2..363	CDD:415822	66/414 (16%)
		PK_GC	553..822	CDD:270894	58/306 (19%)
		HNOBA	<831..879	CDD:400168	5/47 (11%)
		Guanylate_cyc	885..1071	CDD:306677
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900