DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Phlpp and gcy-14

DIOPT Version :9

Sequence 1:	NP_001260558.1	Gene:	Phlpp / 35178	FlyBaseID:	FBgn0032749	Length:	954	Species:	Drosophila melanogaster
Sequence 2:	NP_506660.2	Gene:	gcy-14 / 191647	WormBaseID:	WBGene00001540	Length:	1111	Species:	Caenorhabditis elegans

Alignment Length:	243	Identity:	52/243 - (21%)
Similarity:	81/243 - (33%)	Gaps:	67/243 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   693 TCCDRSNACRHRAIEQEPLAGRSSPSGQSDRDLLAKDKDDEFVLAHARVLQEEQQLEMLDETESV 757
            |..|..|..|:.......|...|...|.  |::|.:.:.||||..::....||:...|.|:.|.:
Worm   124 TAADIGNVSRYPTTVTLSLDTHSMALGV--REVLRRFEWDEFVFIYSNDGDEEKCASMKDDLEKM 186

  Fly   758 ----SESVLSEEQFKCWEYMLEQNTQLL--FDKELNTISK-------SFTKQRTVPNAIMAATVL 809
                |:..|:        ||::..|..|  ..|.|..:||       .|...|....|.:|:|||
Worm   187 GIENSDVTLA--------YMVQIQTVTLDALQKALTEVSKRGRIIIACFANGRGFKKAFVASTVL 243

  Fly   810 --------------PERNDFTSNLMR--------TVTNKFISTSTPQ-----------------L 835
                          |:...|..:.:.        .....|::..||:                 |
Worm   244 AGMSTDEYMYMFAEPQSRGFYVDEINGGEHYSWDDTDGNFVTGLTPEQIRDAYGKVLYICDNMGL 308

  Fly   836 PQPITTSVPLGSYHQVKQAPPGHFG-----SALSFQQAHSYGYNLFDA 878
            |..||......|...:.:.....|.     |..:::...:|...||||
Worm   309 PTTITPEFANFSSQLISRMTEQPFNCVQDCSNSTYKVPATYAGQLFDA 356

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phlpp	NP_001260558.1	leucine-rich repeat	91..110	CDD:275380
		LRR_8	109..169	CDD:290566
		leucine-rich repeat	111..135	CDD:275380
		leucine-rich repeat	136..158	CDD:275380
		leucine-rich repeat	159..183	CDD:275380
		leucine-rich repeat	184..209	CDD:275380
		LRR_8	205..266	CDD:290566
		leucine-rich repeat	210..230	CDD:275380
		leucine-rich repeat	232..255	CDD:275380
		LRR_RI	<256..410	CDD:238064
		leucine-rich repeat	256..276	CDD:275380
		LRR_8	279..359	CDD:290566
		leucine-rich repeat	280..303	CDD:275380
		leucine-rich repeat	304..348	CDD:275380
		leucine-rich repeat	349..372	CDD:275380
		PP2Cc	461..655	CDD:294085
gcy-14	NP_506660.2	PBP1_NPR_GC_like	21..423	CDD:107347	52/243 (21%)
		ANF_receptor	43..418	CDD:279440	52/243 (21%)
		PKc_like	535..800	CDD:304357
		HNOBA	<817..860	CDD:285003
		CYCc	839..1031	CDD:214485
		Guanylate_cyc	866..1053	CDD:278633
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900