DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Phlpp and gcy-9

DIOPT Version :9

Sequence 1:	NP_001260558.1	Gene:	Phlpp / 35178	FlyBaseID:	FBgn0032749	Length:	954	Species:	Drosophila melanogaster
Sequence 2:	NP_509897.3	Gene:	gcy-9 / 191645	WormBaseID:	WBGene00001536	Length:	1081	Species:	Caenorhabditis elegans

Alignment Length:	312	Identity:	75/312 - (24%)
Similarity:	115/312 - (36%)	Gaps:	75/312 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLKATRKQADPYKSKLKVSASHSGPHPLPVEVTAAEEEQ----AATFGQTSPQKLSLKGSQLGGS 61
            ||:...|......||.:.|.|.||         :...:|    ||....::..||::|..|...:
Worm   510 MLEGKSKSEHSLASKSQSSGSFSG---------SMNSKQNGLIAAKQAVSNGVKLAIKRYQQVRN 565

  Fly    62 ILI--GNYNYLTQLEVCENE--MEVLDLSSLAQLETL----KCSRNKLMELIIN-----GTNLQT 113
            |..  .....|.:|::|||:  .:...:|...|.|.:    .|||..|.:::.|     |.|.|.
Worm   566 ITFPKSELRLLKELKICENDNLNKFYGISFNQQNEFIVMWVLCSRGSLEDILFNDELKLGRNFQV 630

  Fly   114 -----LVADHNYLHNISTTNTHPVPLKLQRIDISHNNFSELPNWVGACASLTAINASHNRLNNVA 173
                 :|...|:||  ::...|...|.||...:..|...:|.|:  |..::......||.
Worm   631 SFAKDVVKGLNFLH--TSPLLHHGMLCLQNCLVDSNWTVKLTNF--ATEAVIFEKLDHNE----- 686

  Fly   174 VLLRNYRITELVSLDLAYNDLKQ------LDQFPEGFSSIRSLQL-----QSNELPSLPDNFFAV 227
              ||.:..|:..|.|...:..|.      |.|.||....|.:.:.     ||.::.:|....:.:
Worm   687 --LRPFINTDSESADDVSDPTKDFARKKYLQQAPEIIREIVTTKTIPEGSQSADIYALGMVLYQI 749

  Fly   228 T------HARLETLNVSCNKL-STL-----------PRYEQNNHAALVNLSL 261
            .      |.|    |.|.||| .||           |.:..:|.....||.|
Worm   750 LFRVEPFHER----NKSINKLMETLAMANDDDQLIRPTFPSSNTGEGYNLQL 797

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phlpp	NP_001260558.1	leucine-rich repeat	91..110	CDD:275380	7/27 (26%)
		LRR_8	109..169	CDD:290566	16/64 (25%)
		leucine-rich repeat	111..135	CDD:275380	6/28 (21%)
		leucine-rich repeat	136..158	CDD:275380	6/21 (29%)
		leucine-rich repeat	159..183	CDD:275380	4/23 (17%)
		leucine-rich repeat	184..209	CDD:275380	8/30 (27%)
		LRR_8	205..266	CDD:290566	18/80 (23%)
		leucine-rich repeat	210..230	CDD:275380	3/30 (10%)
		leucine-rich repeat	232..255	CDD:275380	9/34 (26%)
		LRR_RI	<256..410	CDD:238064	3/6 (50%)
		leucine-rich repeat	256..276	CDD:275380	3/6 (50%)
		LRR_8	279..359	CDD:290566
		leucine-rich repeat	280..303	CDD:275380
		leucine-rich repeat	304..348	CDD:275380
		leucine-rich repeat	349..372	CDD:275380
		PP2Cc	461..655	CDD:294085
gcy-9	NP_509897.3	Periplasmic_Binding_Protein_Type_1	66..416	CDD:299141
		ANF_receptor	69..404	CDD:279440
		PKc_like	550..820	CDD:304357	63/263 (24%)
		HNOBA	<837..883	CDD:285003
		CYCc	862..1054	CDD:214485
		Guanylate_cyc	889..1076	CDD:278633
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900