Protein Alignment Phlpp and gcy-3

DIOPT Version :9

• Sequence 1: NP_001260558.1
• Gene: Phlpp / 35178
• FlyBaseID: FBgn0032749
• Length: 954
• Species: Drosophila melanogaster
• Sequence 2: NP_496037.1
• Gene: gcy-3 / 191641
• WormBaseID: WBGene00001530
• Length: 1140
• Species: Caenorhabditis elegans
• Alignment Length: 940
• Identity: 161/940 - (17%)
• Similarity: 294/940 - (31%)
• Gaps: 374/940 - (39%)

  Fly    51 LSLKGSQLGGSILIGNYNY-LTQL-EVCENEMEVLD-LSSLAQLETLKCSRNKLMELIINGTNLQ 112
            :|::....|....:|...: |:.| .|.|:...|.| |.::|:       |.....|:|   :|.
 Worm   269 ISMRSIGFGVQTFVGKTTFKLSGLTPVWESFSNVTDGLENVAK-------RGATNVLVI---DLN 323

  Fly   113 TLVADHNYL----HNISTTNTHPVPLKLQRIDISHNNFSELPNWVGACASLTA--INASHNRLNN 171
            :.|:|..||    .||......| ||....:|               |.|.||  :.|....|.:
 Worm   324 SEVSDKAYLDYMQRNILNVVKLP-PLNCSTVD---------------CVSSTATGMGAYARHLFD 372

  Fly   172 VAVLLRNYRITELVSLDLA-YNDL-KQLDQFPEGFSSIRSLQLQSNELPSLPDNFFAVTHARLET 234
            | |.|....:|.:.|.|.| |:|: |.:.||...|:.:..|
 Worm   373 V-VYLYGIALTRVNSTDSAVYDDMSKLIPQFVTSFNGMTGL------------------------ 412

  Fly   235 LNVSCNK-LSTLPRY------EQNNHAALVNLSLAGNHLNDSIFEPLHNAAKLRVLHLAYNR--- 289
              |:.|: ||.:|.|      ||....:|:|||.|             :...:..:.|||:.
 Worm   413 --VAINQNLSRMPLYQLYGLDEQYEQTSLMNLSFA-------------DGTTVATISLAYSNESS 462

  Fly   290 ----------------IGVLPAAC-VRNWPELEILVLSGN----------------MLQQLPEEV 321
                            .|.|..:| :..|.:..||:..|.                |::...||.
 Worm   463 AVWHFWGGIRPLATPICGFLGNSCPLPFWEQYGILIFVGAGVFLIMITTNLICFLFMIKNRREEQ 527

  Fly   322 ATLG--------QLRVL-----------------------------RCCNNLLLCTPQLAKLAML 349
            |.:.        :||.|                             ..|.|..:   ::.:..|:
 Worm   528 ARINSEWQIPFVKLRELERKSKGTSKRSLQSAPSTITGESKVSTGSEFCENYEV---KMFEKDMV 589

  Fly   350 KVLDLSHNHLDRVNLLALVPSRNLKYLDLSGNLQLQVDEQQF----KVC---------------- 394
            ..:...:.:|::.::...|..|.|.:.:|:..:.|.:|..||    |:|
 Worm   590 LTMKFQYMNLNKADMDKFVKLRKLDHENLNKFIGLSIDSSQFISVTKLCSRGSLLDILYKGNFSM 654

  Fly   395 -------------QSQSQRHWSLVDVSGNNRAALPTTKIRQVSAQRNQNKTSGPWTMGFAETPGS 446
                         :..|..|.|.:.:.||.|:|  |..:            :..|.:..||
 Worm   655 DFFFMYCIIKDVAEGMSYLHKSFLRLHGNLRSA--TCLV------------NDSWQVKLAE---- 701

  Fly   447 GDCRKLSVYQLRAANYGGSDEALYGMFEALEGRGRAAQEMSHLVPDLMKQEQMVKD---SAVRDY 508
                                   :|..:.||......:.:....|::::....|..   ||  |.
 Worm   702 -----------------------FGFDQLLEEITPTKRRLLWAAPEVLRGSLTVSQMDPSA--DV 741

  Fly   509 MKFTLLAAQQQCGSVRSAALFHLTRTRAPSKVRPLKSKRYVLRMASTGGLD--AYLIRRTSQLRL 571
            ..|.::|::            .|||..|    ..||.::        .|.|  .|.:::.....:
 Worm   742 FSFAIIASE------------ILTRKEA----WDLKERK--------EGYDEIIYRVKKGGSFPI 782

  Fly   572 TKPDVIQKDQIHSMPDPHVLELILSNDDEYLVVGNAQLWSVMDIDRAARE---------IRKEEN 627
             :||:|.     .:||.:...:.|..|          .|:....||...|         :.|.::
 Worm   783 -RPDIIT-----DVPDVNPTLIALVKD----------CWAEAPEDRPTAENICEQLRDLMPKTKS 831

  Fly   628 SLLAAKRLVDIAQSFAAAESLSVIVVRFRHLGTDVDHLIRELKQSVRKK--------PQPVSLPL 684
            :|:  ..:.::.:.:.:.            |..:|:...:||....:|.        |:.|:..|
 Worm   832 NLM--DHVFNMLEEYTST------------LEVEVEERTKELTLEKKKADLLLSRMLPKQVAERL 882

  Fly   685 SSGSVCKRTCCDRSNACRHRAIEQEPLAGRSSPSGQSDRDLLAKDKDDEFVLAHARVLQEEQQLE 749
            .:|...:....|.........::...||.:.:|.                           |.:.
 Worm   883 KAGQTVEPEGFDSVTVFFSDVVKFTILASKCTPF---------------------------QVVN 920

  Fly   750 MLDETESVSESVLSEEQFKCWEYMLEQNTQLLFDKELNTISKSFTKQRTVPNAIMAATVLPERND 814
            :|::..|..::::.|.                          ...|..::.:..:..:.||.||.
 Worm   921 LLNDLYSNFDTIIEEH--------------------------GVYKVESIGDGYLCVSGLPTRNG 959

  Fly   815 FTSNLMRTVTN---KFI----STSTPQLPQ 837
            |  |.::.:.:   ||:    :...|.||:
 Worm   960 F--NHIKQIVDMSLKFMDYCKNFKIPHLPR 987

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Phlpp	NP_001260558.1	leucine-rich repeat	91..110	CDD:275380	3/18 (17%)
		LRR_8	109..169	CDD:290566	16/65 (25%)
		leucine-rich repeat	111..135	CDD:275380	9/27 (33%)
		leucine-rich repeat	136..158	CDD:275380	2/21 (10%)
		leucine-rich repeat	159..183	CDD:275380	7/25 (28%)
		leucine-rich repeat	184..209	CDD:275380	9/26 (35%)
		LRR_8	205..266	CDD:290566	14/67 (21%)
		leucine-rich repeat	210..230	CDD:275380	1/19 (5%)
		leucine-rich repeat	232..255	CDD:275380	8/29 (28%)
		LRR_RI	<256..410	CDD:238064	39/259 (15%)
		leucine-rich repeat	256..276	CDD:275380	5/19 (26%)
		LRR_8	279..359	CDD:290566	20/152 (13%)
		leucine-rich repeat	280..303	CDD:275380	7/42 (17%)
		leucine-rich repeat	304..348	CDD:275380	12/96 (13%)
		leucine-rich repeat	349..372	CDD:275380	2/22 (9%)
		PP2Cc	461..655	CDD:294085	32/207 (15%)
gcy-3	NP_496037.1	PBP1_NPR_GC_like	36..453	CDD:107347	58/249 (23%)
		ANF_receptor	54..433	CDD:279440	51/216 (24%)
		PKc_like	554..823	CDD:304357	55/354 (16%)
		HNOBA	<839..882	CDD:285003	7/54 (13%)
		CYCc	861..1051	CDD:214485	25/182 (14%)
		Guanylate_cyc	888..1076	CDD:278633	20/155 (13%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900