DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Phlpp and gcy-1

DIOPT Version :9

Sequence 1:	NP_001260558.1	Gene:	Phlpp / 35178	FlyBaseID:	FBgn0032749	Length:	954	Species:	Drosophila melanogaster
Sequence 2:	NP_496039.1	Gene:	gcy-1 / 191639	WormBaseID:	WBGene00001528	Length:	1137	Species:	Caenorhabditis elegans

Alignment Length:	843	Identity:	143/843 - (16%)
Similarity:	275/843 - (32%)	Gaps:	264/843 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    95 KCSRNKLMELIINGTNLQTLVADHNYLH----NISTTNTHPVPLKLQRIDISHNNFSELPNWVGA 155
            |.:..::..|.:|..     |||..||.    ||......| |:....::....|
Worm   310 KQAATRMFVLDVNSE-----VADKKYLEYMQKNIIKAVQSP-PMNCSTVECMTAN---------- 358

  Fly   156 CASLTAINASHNRLNNVAVLLRNYRITELVSLDLA-YNDLKQL-DQFPEGFSSIRSLQLQSNELP 218
                |.|...:.|.....|.|....:|...|.|.| |.|:..| .||...|..:....:.|..|.
Worm   359 ----TTIMGGYARHLFDVVYLYGIALTHTNSTDPAVYGDVDVLVHQFVTSFQGMTGHVVISPNLT 419

  Fly   219 SLPDNFFAVTHARLETLNVSCNKLSTLPRYEQNNHAALVNLSLAGNHLNDSIFEPLHNAAKLRVL 283
            .:|  .|     :|..||...:::: |..:...|...:.|::|.......:::....::..|.:
Worm   420 RMP--IF-----QLYGLNSDYDQVA-LVDFTYTNSVMVPNVTLFYKDEGGAVWSYYGHSRPLDI- 475

  Fly   284 HLAYNRIGVLPAAC-VRNWPELEIL---------------------VLSG--------NMLQQLP 318
                ...|.|..:| |..|.:.:||                     |:||        |...|:|
Worm   476 ----PICGFLGKSCPVSFWEQYKILIFVAIAVIVLMVLIMIIGCLCVISGKRAERARINAEWQVP 536

  Fly   319 --------EEVATLGQLR------------------VLRCCNNLLLCTPQLAKLAMLKVLDLSHN 357
                    ::|...|..|                  |...|.|.   |..:.:..|:......:.
Worm   537 FAKLIESEKQVRGKGASRRSLQSAPSISTGHSGVTTVSDFCENY---TMMMYEKEMVLTAKYQYT 598

  Fly   358 HLDRVNLLALVPSRNLKYLDLSGNLQLQVDEQQF----KVCQSQSQRHWSLVDVSGNNRAALP-- 416
            ||.:.:....|..|.|.:.:::..:.|.:|...|    |:|.     ..||.|:......::.
Worm   599 HLTKADKERFVKMRKLDHENINRFIGLSIDSAHFISVTKLCS-----RGSLQDILSRGNFSMDYF 658

  Fly   417 --TTKIRQVS-AQRNQNKTSGPWTMGFAETPG---SGDCRKLSVYQLRAANYGGSDEALYGMFEA 475
              ...||.|: .....:||       |....|   |..|.....:|::.|.        |||...
Worm   659 FMFCIIRDVAKGLEYLHKT-------FLRLHGNLRSATCLVNDSWQVKLAE--------YGMDNL 708

  Fly   476 LEGRGRAAQEMSHLVPDLMK---QEQMVKDSAVRDYMKFTLLAAQQQCGSVRSAALFHLTRTRAP 537
            :|.:....:.:..:.|::::   ....::.||  |...|.::|::            .||:..|.
Worm   709 VEEQTPPKKRLLWVAPEVLRGSLSVSQMEPSA--DIYSFAIIASE------------ILTKKEAW 759

  Fly   538 SKVRPLKSKRYVLRMASTGGLDAYLIRRTSQLRLTKPDVIQKDQIHSMPDPHVLELILSNDDEYL 602
            ..:...:....::.....|||  :.||         |::|  ..||.: :|.::.|:
Worm   760 DILDRKEDCEEIVYNVKKGGL--FPIR---------PEII--TDIHDV-NPALIALV-------- 802

  Fly   603 VVGNAQLWSVMDIDRAARE---------IRKEENSLLAAKRLVDIAQSFAAAESLSVIVVRFRHL 658
                ...|:.:..||...|         :.|::.:|:  ..:.::.:.:.:.            |
Worm   803 ----KDCWAEVPEDRPTAENICSQMKGLVSKQKTNLM--DHVFNMLEEYTST------------L 849

  Fly   659 GTDVDHLIRELKQSVRKK--------PQPVSLPLSSGSVCKRTCCDRSNACRHRAIEQEPLAGRS 715
            ..:::...:||....:|.        |:.|:..|.:|...:....|.........::...||.:.
Worm   850 EEEIEERTKELTLEKKKADILLSRMLPKQVAERLKAGQTVEPEGFDSVTVFFSDVVKFTILASKC 914

  Fly   716 SPSGQSDRDLLAKDKDDEFVLAHARVLQEEQQLEMLDETESVSESVLSEEQFKCWEYMLEQNTQL 780
            ||.                           |.:.:|::..|..::::.:.
Worm   915 SPF---------------------------QTVNLLNDLYSNFDTIIEQH--------------- 937

  Fly   781 LFDKELNTISKSFTKQRTVPNAIMAATVLPERNDFTSNLMRTV--TNKFI----STSTPQLPQ 837
                       ...|..::.:..:..:.||.||.: :::.:.|  :.||:    |.:.|.||:
Worm   938 -----------GVYKVESIGDGYLCVSGLPTRNGY-AHIKQIVDMSLKFMEYCKSFNIPHLPR 988

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phlpp	NP_001260558.1	leucine-rich repeat	91..110	CDD:275380	3/14 (21%)
		LRR_8	109..169	CDD:290566	12/63 (19%)
		leucine-rich repeat	111..135	CDD:275380	9/27 (33%)
		leucine-rich repeat	136..158	CDD:275380	1/21 (5%)
		leucine-rich repeat	159..183	CDD:275380	5/23 (22%)
		leucine-rich repeat	184..209	CDD:275380	9/26 (35%)
		LRR_8	205..266	CDD:290566	11/60 (18%)
		leucine-rich repeat	210..230	CDD:275380	4/19 (21%)
		leucine-rich repeat	232..255	CDD:275380	5/22 (23%)
		LRR_RI	<256..410	CDD:238064	37/213 (17%)
		leucine-rich repeat	256..276	CDD:275380	2/19 (11%)
		LRR_8	279..359	CDD:290566	22/135 (16%)
		leucine-rich repeat	280..303	CDD:275380	6/23 (26%)
		leucine-rich repeat	304..348	CDD:275380	15/98 (15%)
		leucine-rich repeat	349..372	CDD:275380	3/22 (14%)
		PP2Cc	461..655	CDD:294085	30/205 (15%)
gcy-1	NP_496039.1	PBP1_NPR_GC_like	35..449	CDD:107347	37/166 (22%)
		ANF_receptor	53..432	CDD:279440	35/148 (24%)
		PKc_like	555..821	CDD:304357	57/328 (17%)
		HNOBA	<840..883	CDD:285003	6/54 (11%)
		CYCc	862..1051	CDD:214485	25/181 (14%)
		Guanylate_cyc	889..1077	CDD:278633	20/154 (13%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900