DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Phlpp and phlp-2

DIOPT Version :9

Sequence 1:NP_001260558.1 Gene:Phlpp / 35178 FlyBaseID:FBgn0032749 Length:954 Species:Drosophila melanogaster
Sequence 2:NP_001337270.1 Gene:phlp-2 / 185690 WormBaseID:WBGene00009647 Length:1126 Species:Caenorhabditis elegans


Alignment Length:825 Identity:191/825 - (23%)
Similarity:339/825 - (41%) Gaps:164/825 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly    38 EQAATFGQTSPQKLSLKGSQLGGSILIGNYNYLTQLEVCENEM-EVLDLSSLAQLETLKCSRNKL 101
            |:....|:...||:.|:.:.|..|..:...| :|.|::.:|.| ..:.|::|..|:.:.|.|.:|
 Worm   391 EKIDRVGEMQIQKIDLRRNVLDTSFRLDIEN-ITHLDLRDNSMISTVHLTNLRFLKVIHCERLQL 454

  Fly   102 MELIINGTNLQTLVADHNYLHNISTTNTHPVPLKLQRIDISHNNFSELPNWVGACASLTAINASH 166
            ..|.::|.:|..:.||||.|.::...   |:|..||.:.:|.|:|..||:|:..|.:||.:.|::
 Worm   455 SSLHLSGESLTHVYADHNLLDSLVVM---PLPQNLQTLSLSFNHFRNLPDWISDCPNLTFLRANN 516

  Fly   167 NRLNNVAVLLRNYRITELVSLDLAYNDLKQLDQFPEGFSSIRSLQLQSNELPSLPDNFFAVTHAR 231
            |.|  ||:..|.:....|.|:....|:::.:..|.|. :.:.:|.|..|:|.|||.:||::. .|
 Worm   517 NSL--VALPERIFYSQSLRSIFAFINEIEHIPDFGEE-NCLETLILYKNKLSSLPKHFFSIL-PR 577

  Fly   232 LETLNVSCNKLSTLPRYEQNNHAALVNLSLAGNHLNDSIFEPLHNAAKLRVLHLAYNRIGVLPAA 296
            |..||:|.|.:..||.::.::...|..|..|.|:|.::....:.|...|:::.|::||:.....:
 Worm   578 LRQLNISSNFIELLPYFDGSSFCRLQILRCANNYLTENSVPVIVNMKHLKIIDLSHNRLNSFDDS 642

  Fly   297 CVRNWPELEILVLSGNMLQQLPEEVATLGQLRVLRCCNNLLLCTPQLAKLAMLKVLDLSHNHLDR 361
            .:.:...||.|.||.|.|.:|.:.:|.|..|:|||..:|.|:..|:......|..:|:|.|::..
 Worm   643 ALSSLELLEDLNLSSNRLTRLADCLALLPCLQVLRAHSNQLVHVPEFRASNQLHTIDVSSNNISL 707

  Fly   362 VNLLALVPSRNLKYLDLSGNLQLQVDEQQFKVCQSQSQRHWSLVDVSGNNRAALPTTKIRQVSAQ 426
            ..|....|. ||::.|::.| ....|.:.|   ...::.|                :|:..::..
 Worm   708 GTLQFKAPP-NLRHFDVTCN-SGDFDTENF---PENAKMH----------------SKMNTINIS 751

  Fly   427 RNQNKTSGPWTMGFAETPGSGDCRKLSVYQLRAANYGGSDEALYGMFEALEGRGRAAQEMSHLVP 491
            .......| :.:|.:.:.|..:  |..:.|:|..|       .:|..:     |.:...||..:.
 Worm   752 EGSQNLFG-FQIGVSGSRGMKN--KQCIRQVRVEN-------TFGFID-----GGSNSYMSSSIC 801

  Fly   492 DLMKQEQMVKDSAVRDYMKFTLLAAQQQCGSVRSAALFHLTRTRAPSKVRPLKSKRYVLRMASTG 556
            ..|  ...:|::...| ::..||....:.|....       |..|...:..:..||  |.:||||
 Worm   802 RFM--TSYLKENVSMD-IRSILLRCHCELGEEGE-------RLGASVMIIRVHEKR--LEIASTG 854

  Fly   557 GLDAYLIRRT-----------------SQLRLTKPDVIQKDQI-----------HSMPDPHVL-- 591
            .:.|.:.|..                 |::|.....|.::::|           |....|.||  
 Worm   855 TMSAAIARNQKLKMIINGRYEIDDDEYSRIREAHGFVDEENRINGVIGSSRQIGHFSTFPVVLPT 919

  Fly   592 ----ELILSNDDEYLVVGNAQLWSVMDIDRAAREIRKEENSLLAAKRLVDIAQSFAAAESLSVIV 652
                .:.|:...|.|:|||..:|:::.||..........:.::.||::.|..||:....:.:::|
 Worm   920 HSYRNIQLNEQIEGLIVGNNMIWNMLSIDDLNSTFHNNRSPIVVAKKIQDQLQSYDYGGNSNILV 984

  Fly   653 VRFRHLGTDVDHLIRELKQSVRKKPQPVSLPLSSGSVCKRTCCDRS------------------- 698
            :|                   |.|||......|:.|...:...|.:                   
 Worm   985 LR-------------------RIKPQMTFNGFSTSSTKNQVTPDIAIPKIDEQLVLAVPALILPE 1030

  Fly   699 -----------NACRHR--AIEQEPLAGRSSPSGQSDRDLLAKDKDDEFVLAHARVLQEEQQLEM 750
                       .|.|||  :....||...:.|...|:.        :|..:..:..|.....|. 
 Worm  1031 YHPSPPVPPPIPAIRHRTPSPPPPPLPSSTPPPVSSEH--------EEINVRQSSTLSGGYTLS- 1086

  Fly   751 LDETESVSESVLSEEQFKCWEYMLEQNTQLLFDKEL-----NTIS 790
            :|...|.|.:|.|.:||        ..|:.|..|.|     ||::
 Worm  1087 IDRFYSSSSTVSSRKQF--------NETRDLLSKSLKLSPPNTVT 1123

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PhlppNP_001260558.1 leucine-rich repeat 91..110 CDD:275380 6/18 (33%)
LRR_8 109..169 CDD:290566 21/59 (36%)
leucine-rich repeat 111..135 CDD:275380 8/23 (35%)
leucine-rich repeat 136..158 CDD:275380 9/21 (43%)
leucine-rich repeat 159..183 CDD:275380 8/23 (35%)
leucine-rich repeat 184..209 CDD:275380 5/24 (21%)
LRR_8 205..266 CDD:290566 21/60 (35%)
leucine-rich repeat 210..230 CDD:275380 9/19 (47%)
leucine-rich repeat 232..255 CDD:275380 7/22 (32%)
LRR_RI <256..410 CDD:238064 40/153 (26%)
leucine-rich repeat 256..276 CDD:275380 5/19 (26%)
LRR_8 279..359 CDD:290566 25/79 (32%)
leucine-rich repeat 280..303 CDD:275380 4/22 (18%)
leucine-rich repeat 304..348 CDD:275380 17/43 (40%)
leucine-rich repeat 349..372 CDD:275380 6/22 (27%)
PP2Cc 461..655 CDD:294085 45/227 (20%)
phlp-2NP_001337270.1 leucine-rich repeat 232..253 CDD:275380
leucine-rich repeat 254..288 CDD:275380
PLN00113 283..>718 CDD:331614 100/335 (30%)
leucine-rich repeat 289..311 CDD:275380
leucine-rich repeat 312..334 CDD:275380
leucine-rich repeat 335..357 CDD:275380
leucine-rich repeat 358..379 CDD:275380
leucine-rich repeat 380..440 CDD:275380 13/49 (27%)
leucine-rich repeat 441..485 CDD:275380 15/46 (33%)
leucine-rich repeat 486..508 CDD:275380 9/21 (43%)
leucine-rich repeat 509..534 CDD:275380 9/26 (35%)
leucine-rich repeat 554..577 CDD:275380 9/23 (39%)
leucine-rich repeat 578..602 CDD:275380 7/23 (30%)
leucine-rich repeat 603..625 CDD:275380 5/21 (24%)
leucine-rich repeat 626..649 CDD:275380 4/22 (18%)
leucine-rich repeat 650..672 CDD:275380 10/21 (48%)
leucine-rich repeat 673..694 CDD:275380 7/20 (35%)
PP2Cc 754..985 CDD:214625 50/257 (19%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 106 1.000 Domainoid score I4146
eggNOG 1 0.900 - - E1_COG2114
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 1 0.950 - 0 Normalized mean entropy S5072
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D172467at2759
OrthoFinder 1 1.000 - - FOG0003647
OrthoInspector 1 1.000 - - oto20750
orthoMCL 1 0.900 - - OOG6_102913
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R9772
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
1110.660

Return to query results.
Submit another query.