DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Phlpp and gcy-20

DIOPT Version :9

Sequence 1:	NP_001260558.1	Gene:	Phlpp / 35178	FlyBaseID:	FBgn0032749	Length:	954	Species:	Drosophila melanogaster
Sequence 2:	NP_507101.1	Gene:	gcy-20 / 184797	WormBaseID:	WBGene00001545	Length:	1108	Species:	Caenorhabditis elegans

Alignment Length:	170	Identity:	30/170 - (17%)
Similarity:	61/170 - (35%)	Gaps:	51/170 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   133 PLKLQRIDISHNNFSELPNWVGACASLTAINASHNRLNNVAVLLRNYRITELVSLDLAYNDLKQL 197
            |...:::.|..::..:.....|.|..|..:..    ||::      |.|.:.:   :..||:.::
Worm   869 PETFEQVTIFFSDVVQFTTLAGKCTPLQVVTL----LNDL------YTIFDGI---IEQNDVYKV 920

  Fly   198 DQFPEGFSSIRSL-------------QLQSNELPSLPDNFFAVTHARLETLN----VSCNKL--- 242
            :...:|:..:..|             ::....|.||  .||.|.|...|.:|    ::|..:
Worm   921 ETIGDGYLCVSGLPHRNGNDHIRHIARMSLGFLSSL--EFFRVQHLPAERINLRIGINCGSVVAG 983

  Fly   243 ---STLPRY-------------EQNNHAALVNLSLAGNHL 266
               .|:|||             |.|.....::::...|.:
Worm   984 VVGLTMPRYCLFGDAVNTASRMESNGKPGQIHVTAEANRM 1023

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phlpp	NP_001260558.1	leucine-rich repeat	91..110	CDD:275380
		LRR_8	109..169	CDD:290566	5/35 (14%)
		leucine-rich repeat	111..135	CDD:275380	1/1 (100%)
		leucine-rich repeat	136..158	CDD:275380	3/21 (14%)
		leucine-rich repeat	159..183	CDD:275380	5/23 (22%)
		leucine-rich repeat	184..209	CDD:275380	3/24 (13%)
		LRR_8	205..266	CDD:290566	18/96 (19%)
		leucine-rich repeat	210..230	CDD:275380	7/32 (22%)
		leucine-rich repeat	232..255	CDD:275380	9/45 (20%)
		LRR_RI	<256..410	CDD:238064	1/11 (9%)
		leucine-rich repeat	256..276	CDD:275380	1/11 (9%)
		LRR_8	279..359	CDD:290566
		leucine-rich repeat	280..303	CDD:275380
		leucine-rich repeat	304..348	CDD:275380
		leucine-rich repeat	349..372	CDD:275380
		PP2Cc	461..655	CDD:294085
gcy-20	NP_507101.1	PBP1_NPR_GC_like	22..439	CDD:107347
		ANF_receptor	44..418	CDD:279440
		PKc_like	536..801	CDD:304357
		STYKc	562..801	CDD:214568
		HNOBA	<818..861	CDD:285003
		CYCc	840..1032	CDD:214485	30/170 (18%)
		Guanylate_cyc	867..1054	CDD:278633	30/170 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900