DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Phlpp and gcy-11

DIOPT Version :9

Sequence 1:	NP_001260558.1	Gene:	Phlpp / 35178	FlyBaseID:	FBgn0032749	Length:	954	Species:	Drosophila melanogaster
Sequence 2:	NP_001359843.1	Gene:	gcy-11 / 181745	WormBaseID:	WBGene00001537	Length:	1168	Species:	Caenorhabditis elegans

Alignment Length:	789	Identity:	144/789 - (18%)
Similarity:	267/789 - (33%)	Gaps:	276/789 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   301 WPEL-EILVLSGNMLQQLPEEVATLGQLRVLRCCNNLLLCTPQLAKLAMLKVLDLSHNHLDRVNL 364
            |..| ::.:.:|.:.|..||            |..|..||...:..|:.|:::.::   :..|.:
Worm   479 WKNLTQLGIFNGELPQSKPE------------CGFNNELCPAGIRNLSELEIIVIA---VCVVAI 528

  Fly   365 LALVP-----SRNLKYLDLSGNLQLQVDEQQFKVCQSQSQRHWSLVDVS--GNNRAALPTTKIRQ 422
            |.||.     :|.:.|       :.:::...|.|    .::|..|||::  |::|..   :.|:.
Worm   529 LILVGVIAYIARWIAY-------ERRLESSYFLV----HRKHVQLVDMTKFGSSRGG---SMIQS 579

  Fly   423 VSAQRNQNKTSGP---WTMGFAETPGSGDCRKLSV--YQLRAANYG---GSDEAL---------- 469
            ..:.|:|.:.|||   .||.|.    :...||.::  .|::.::.|   ..||.|
Worm   580 AMSMRSQYEDSGPVGGATMNFY----TNGIRKAAIRRNQMQRSDKGPAANRDEWLEIVDWHLAKY 640

  Fly   470 ---------------------------------------YGMFE------ALEGRGRAAQEMSHL 489
                                                   :|:..      .:...|.....|..|
Worm   641 ENTLVTVRKINKTQLKLTREMKQEIDLLMNETHENLNRFFGLINESDLIFTIHSYGPRKSLMDLL 705

  Fly   490 VPDLMKQEQMVKDSAVRDYMK-FTLLAAQQQCGSVRSAALFHLTRTRAPSKVRPLKSKRYVLRMA 553
            ..|.::.::|.|.|.|.|.:| ...|....:.|       :|          ..|||...:
Worm   706 RNDDLRLDRMFKVSFVEDVVKGLQFLHEGSKIG-------YH----------GNLKSSNCI---- 749

  Fly   554 STGGLDAYLIRRTS-----QLRLTKPDVIQKDQIHSMPDPHVLELILSNDDEYLVVGNAQLWSVM 613
                :|||...:.|     |:|:.:|:        |.||.                   .||...
Worm   750 ----VDAYWRIKLSNYGMEQIRVEEPE--------SKPDD-------------------LLWFAP 783

  Fly   614 DIDRAAREIRKEENSLLAAKRLVDIAQSFAAAESLSVIVVRFRHLG---------TDVDHLIREL 669
            :|.|  |...|.:.|.|          ..|.|:..|:.:|.:...|         .|.|.:|.:|
Worm   784 EIIR--RYAVKHDLSKL----------ELAKADIYSLAIVLYEIYGRQGPFGDDLLDSDEIIEQL 836

  Fly   670 K------------QSVRKKPQPVSLPLSSGSVCKRTCCDRSNACRHRAIEQ-----EPLA-GRSS 716
            |            ..:.|.|.|::      ||.::  |...:.....:|::     :||: |...
Worm   837 KFPDGGALTRPDIHLITKAPYPLA------SVVEK--CWVEDPASRPSIKKVRELLKPLSKGLKG 893

  Fly   717 PSGQSDRDLLAKDKD--DEFVLAHARVLQEEQQ------LEMLDETESVSESVLSEEQFKCWEY- 772
            ....:..:||.:.::  ::.:......|::|::      |::|  .:||:.|:.:.:......|
Worm   894 NIADNIMNLLDRYRNNLEDVIKERTEQLEDERKRNESLLLQLL--PKSVANSLKNGQPVDAEFYD 956

  Fly   773 --------------MLEQNTQLLFDKELNTISKSFT---------KQRTVPNAIMAATVLPERND 814
                          :..::|.|.....||.:..:|.         |..|:.:|.|..:.|||.|.
Worm   957 SVSIYFSDIVGFTALSSKSTPLQVVNMLNNLYTNFDTIIDKFDCYKVETIGDAYMFVSGLPEVNS 1021

  Fly   815 FTSNLMRTVTNKFISTSTPQLPQPITTSVPLGSYHQVKQAPPGHFGSALSFQQAHSYGYNLFDAK 879
            :..      ..:..|.|...|....|.:|......:::.....|.|..::    ...|..:
Worm  1022 YLH------AGEVASASLELLDSIKTFTVSHCPDEKLRLRIGNHTGPVVT----GVVGIRM---- 1072

  Fly   880 PRPKFHGGTVKRSAGPNSAYFGSLQRLMPYNFEYDFA------VTQERERNILDEEEHDDDDFNE 938
            ||....|.||..:....|:  |...|:...:..|:..      ||::||:.:|           :
Worm  1073 PRYCLFGDTVIIANMMESS--GEPMRIQISSDAYELILKCGGYVTEQREKIVL-----------K 1124

  Fly   939 HESRMRKYW 947
            ::..:..||
Worm  1125 NKLEVMTYW 1133

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phlpp	NP_001260558.1	leucine-rich repeat	91..110	CDD:275380
		LRR_8	109..169	CDD:290566
		leucine-rich repeat	111..135	CDD:275380
		leucine-rich repeat	136..158	CDD:275380
		leucine-rich repeat	159..183	CDD:275380
		leucine-rich repeat	184..209	CDD:275380
		LRR_8	205..266	CDD:290566
		leucine-rich repeat	210..230	CDD:275380
		leucine-rich repeat	232..255	CDD:275380
		LRR_RI	<256..410	CDD:238064	24/116 (21%)
		leucine-rich repeat	256..276	CDD:275380
		LRR_8	279..359	CDD:290566	12/58 (21%)
		leucine-rich repeat	280..303	CDD:275380	1/1 (100%)
		leucine-rich repeat	304..348	CDD:275380	10/44 (23%)
		leucine-rich repeat	349..372	CDD:275380	5/27 (19%)
		PP2Cc	461..655	CDD:294085	43/257 (17%)
gcy-11	NP_001359843.1	Periplasmic_Binding_Protein_type1	<234..452	CDD:385651
		PKc_like	640..890	CDD:389743	54/321 (17%)
		CYCc	923..1116	CDD:214485	38/210 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900