DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Phlpp and let-4

DIOPT Version :9

Sequence 1:	NP_001260558.1	Gene:	Phlpp / 35178	FlyBaseID:	FBgn0032749	Length:	954	Species:	Drosophila melanogaster
Sequence 2:	NP_510425.2	Gene:	let-4 / 181554	WormBaseID:	WBGene00002282	Length:	773	Species:	Caenorhabditis elegans

Alignment Length:	865	Identity:	174/865 - (20%)
Similarity:	296/865 - (34%)	Gaps:	285/865 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 LGGSILIGNYN----YLTQLEVCENEME---VLDLSS------LAQLETLKCSRNKLMELIINGT 109
            |..::||.:.|    .:||...| :|:.   |||.|:      |..:.|.:.....:..|.:|..
Worm     9 LFSTLLINSTNACPGVITQACFC-SEVHSGIVLDCSNSSASGILQIIRTNQAQVGLIQSLTMNQA 72

  Fly   110 NLQTLVADHNYLHNISTTNTHPVPLKLQRIDISHNNFSELPN--WVGACASLTAINASHNRLNNV 172
            .|..|  ..|:...          |.::|:|:|.|...::.:  :.|....|..:..:||.:..|
Worm    73 ELVEL--PPNFFSG----------LFIRRLDLSQNKIKKIDDAAFAGINPVLEEVVLNHNLIEKV 125

  Fly   173 -AVLLRNYRITELVSLDLAYNDLKQLDQ---FPEGFSSIRSLQLQSNELPSLPDNFFAVTHARLE 233
             |..|..  :..|:.|||:.|.:.::.:   || ..:.:..:.|.||::.|:..:.|......::
Worm   126 PAAALAG--LPNLLRLDLSNNSIVEIQEQEIFP-NLNKLYDINLGSNKIFSIHTSTFQNVKNSIQ 187

  Fly   234 TLNVSCNKLSTLPRYEQNNHAALVNL-SLAGNHLNDSIFEPLH-----NAAKLRVLHLAYNRIGV 292
            |:|:..|.::.:|      .:|:..| .|...||:.:..|.|.     |...|.:|:||.|:|..
Worm   188 TINLGHNNMTAVP------SSAIRGLKQLQSLHLHKNRIEQLDALNFLNLPVLNLLNLAGNQIHE 246

  Fly   293 LPAACVRNWPELEILVLSGNMLQQLPE-EVATLGQLRVLRCCNNLLLCTP--QLAKLAMLKVLDL 354
            |......|.|.|..|.||||.:.:|.. :..|..||.:|...||.:...|  .|:.|..|:.|.|
Worm   247 LNRQAFLNVPSLRYLYLSGNKITKLTAYQFQTFEQLEMLDLTNNEIGAIPANSLSGLKQLRQLYL 311

  Fly   355 SHNHLDRVNLLALVPSRNLKYLDLSGNLQLQVDEQQFKVCQSQSQRHWSLVDVSGNNRAALPTTK 419
            :||.:..::..|...| ::..|.||.|                     .|..::....:.||  .
Worm   312 AHNKISNISSNAFTNS-SIVVLVLSSN---------------------ELKTLTAGIISGLP--N 352

  Fly   420 IRQVSAQRNQNKTSGPWTMGFAETPGSGDCRKLSVYQLRAANYGGSDEALYGMFEALEGRGRAAQ 484
            ::|||.:.||.||..                       |.|.|   |.|...|.:.      |..
Worm   353 LQQVSFRDNQIKTIN-----------------------RNAFY---DAASLVMLDL------AKN 385

  Fly   485 EMSHLVPDLMKQEQMVKDSAVRDYMKFTLLAAQQQCGSVRSAALFHLTRTRAPSKVRPLKSKRYV 549
            :::.:.|.                   |.||
Worm   386 QLTEIAPT-------------------TFLA---------------------------------- 397

  Fly   550 LRMASTGGLDAYLIRRTSQLRLTKPDVIQKDQIHSMPDPHVLELILSNDDEYLVVGNAQLWSVMD 614
                              ||.|...| :.::::...|              |... |:::.:|:
Worm   398 ------------------QLNLLLVD-LSENKLPKTP--------------YSAF-NSRVGTVL- 427

  Fly   615 IDRAAREIRKEENSLLAAKRLVDIAQSFAAAESLSVIVVRFRHLGTDVDHLIRELKQSV--RK-- 675
                     .:||.|:..:.|..:.|                  ||.|  .:|:....:  ||
Worm   428 ---------LKENPLVCTENLHMLQQ------------------GTGV--YVRDSPDIICGRKPT 463

  Fly   676 -KPQPVSLPLSSGSVCK-------------------RTCCDRSNACRHRAIEQEPLA-GRSSPSG 719
             ||:||.:|:.:.|:..                   .|..|::......|.:|..|. .||.|.|
Worm   464 PKPEPVLVPIVTDSLISTQRPALVQIPKMQIHRNVHTTTGDQAPQIPSGAFQQIDLGKSRSLPRG 528

  Fly   720 QSDRDLLAKDKDDEFVLAHARVLQEEQQLEMLDETESVSESVLSEEQFKCWEYMLEQNTQLLFDK 784
            .| |.:|.|..            ..||.:|..:|...:...:|...:.:..:..:|..|.   .:
Worm   529 HS-RFILDKPS------------TREQSVEPTEELTPIQPIILPSREDEIRQSSMEAGTS---QE 577

  Fly   785 ELNTISKSFTKQRTV---PNAIMAATV--------LPERNDFTSNLMRTVTNKFIST-------- 830
            .:...|:.......:   ||.::...|        |.|.....|..|.:.:..|.:.
Worm   578 SVEATSQKIPSTTDIIDRPNVVLPFPVPFLKRGPNLSESKKVESTDMPSTSQVFHTLPPSILIEP 642

  Fly   831 -STPQLPQPITTSVPLGSYH 849
             |||::.|| :|...:.|.|
Worm   643 GSTPKVAQP-STEANIKSEH 661

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phlpp	NP_001260558.1	leucine-rich repeat	91..110	CDD:275380	3/18 (17%)
		LRR_8	109..169	CDD:290566	12/61 (20%)
		leucine-rich repeat	111..135	CDD:275380	3/23 (13%)
		leucine-rich repeat	136..158	CDD:275380	5/23 (22%)
		leucine-rich repeat	159..183	CDD:275380	6/24 (25%)
		leucine-rich repeat	184..209	CDD:275380	7/27 (26%)
		LRR_8	205..266	CDD:290566	12/61 (20%)
		leucine-rich repeat	210..230	CDD:275380	5/19 (26%)
		leucine-rich repeat	232..255	CDD:275380	4/22 (18%)
		LRR_RI	<256..410	CDD:238064	44/162 (27%)
		leucine-rich repeat	256..276	CDD:275380	6/25 (24%)
		LRR_8	279..359	CDD:290566	30/82 (37%)
		leucine-rich repeat	280..303	CDD:275380	8/22 (36%)
		leucine-rich repeat	304..348	CDD:275380	16/46 (35%)
		leucine-rich repeat	349..372	CDD:275380	7/22 (32%)
		PP2Cc	461..655	CDD:294085	22/193 (11%)
let-4	NP_510425.2	leucine-rich repeat	66..86	CDD:275380	5/31 (16%)
		LRR_RI	<71..275	CDD:238064	55/224 (25%)
		LRR_8	88..146	CDD:290566	16/59 (27%)
		leucine-rich repeat	88..111	CDD:275380	5/22 (23%)
		leucine-rich repeat	112..135	CDD:275380	6/24 (25%)
		leucine-rich repeat	136..160	CDD:275380	7/24 (29%)
		LRR_8	156..220	CDD:290566	15/70 (21%)
		leucine-rich repeat	161..184	CDD:275380	5/22 (23%)
		leucine-rich repeat	186..209	CDD:275380	6/28 (21%)
		leucine-rich repeat	210..257	CDD:275380	14/46 (30%)
		LRR_RI	<250..411	CDD:238064	54/288 (19%)
		LRR_8	256..316	CDD:290566	22/59 (37%)
		leucine-rich repeat	258..281	CDD:275380	8/22 (36%)
		leucine-rich repeat	282..305	CDD:275380	7/22 (32%)
		leucine-rich repeat	306..328	CDD:275380	7/22 (32%)
		LRR_8	327..387	CDD:290566	22/115 (19%)
		leucine-rich repeat	329..350	CDD:275380	5/41 (12%)
		leucine-rich repeat	353..400	CDD:275380	19/149 (13%)
		leucine-rich repeat	356..376	CDD:275380	10/45 (22%)
		leucine-rich repeat	401..419	CDD:275380	4/32 (13%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910