DRSC/TRiP Functional Genomics Resources

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Protein Alignment Phlpp and gcy-32

DIOPT Version :9

Sequence 1:NP_001260558.1 Gene:Phlpp / 35178 FlyBaseID:FBgn0032749 Length:954 Species:Drosophila melanogaster
Sequence 2:NP_506452.5 Gene:gcy-32 / 179887 WormBaseID:WBGene00001552 Length:684 Species:Caenorhabditis elegans


Alignment Length:378 Identity:70/378 - (18%)
Similarity:135/378 - (35%) Gaps:98/378 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly   192 NDLKQLDQFPEGFSSIRSLQLQSNELPSLPDNFFAVTHARLETLNVSCNKLS-TLP-RYEQNNHA 254
            |:|.:..:..|| |.:..|...:...|::.|          :||.:|.:..| .|| .:..:...
 Worm   192 NNLSEPRRDSEG-SEVSLLTSTNANFPTIVD----------DTLGISLDDFSKALPYHFVIDESC 245

  Fly   255 ALVNL-SLAGNHLNDSIFEPLHNAAKLRVLHL-----------AYNRIGVLPAACVRNWPELEIL 307
            .||.. |...||:.:.:.:|  ....||:..:           ..|.|..:....|:..| |:..
 Worm   246 KLVQCGSELHNHIPNELLQP--GTPILRIFEINRPQIPLDFENICNFINAVFVLQVKTSP-LKKK 307

  Fly   308 VLSGNMLQQLPEEVATL-----------------GQLRVLRCCNNLL-LCTPQLAKLAMLKVLDL 354
            .:.....::|.:|:.||                 ||:.:|....::: ||:|.:..:..|....:
 Worm   308 HMDAMSQEELKQEMETLDEDATNELTQGHHLKLKGQMMLLASKKHIIYLCSPYVTSINELMQYGM 372

  Fly   355 SHNHL---DRVNLLALVPSRNLKYLDLSGNLQLQVDEQQFKV----CQSQSQRHWSLVDVSGNNR 412
            ....:   |....|.|:..:.|.  |:..||||:.:.:|.:.    .:.:.|:..|::      :
 Worm   373 RLTAMPLHDATRDLILLNQQRLS--DVEVNLQLEANNEQLETMTRELELERQKTDSIL------K 429

  Fly   413 AALPTTKIRQVSAQRNQNKTSGPWTMGFAETPGSGDC-----------------RKL-------S 453
            ..||....:|:.:..:........|:.|.:.|.....                 |||       .
 Worm   430 DMLPRRIAQQLLSGEHIEACEHEATVMFCDLPAFQQAIPQCSPKDIVNMLNEIFRKLDRIVVIRG 494

  Fly   454 VYQLRAANYGGSDEALYGMFEALEG----RGRAAQEMSHLVPDLMKQEQMVKD 502
            ||::         |.:...:.|:.|    ....|:.|.|:...:|.:.:.|.|
 Worm   495 VYKV---------ETVSDSYMAVSGIPDYTPEHAENMCHVALGMMWEARSVID 538

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PhlppNP_001260558.1 leucine-rich repeat 91..110 CDD:275380
LRR_8 109..169 CDD:290566
leucine-rich repeat 111..135 CDD:275380
leucine-rich repeat 136..158 CDD:275380
leucine-rich repeat 159..183 CDD:275380
leucine-rich repeat 184..209 CDD:275380 5/16 (31%)
LRR_8 205..266 CDD:290566 14/63 (22%)
leucine-rich repeat 210..230 CDD:275380 3/19 (16%)
leucine-rich repeat 232..255 CDD:275380 6/24 (25%)
LRR_RI <256..410 CDD:238064 36/190 (19%)
leucine-rich repeat 256..276 CDD:275380 6/20 (30%)
LRR_8 279..359 CDD:290566 18/108 (17%)
leucine-rich repeat 280..303 CDD:275380 5/33 (15%)
leucine-rich repeat 304..348 CDD:275380 11/61 (18%)
leucine-rich repeat 349..372 CDD:275380 4/25 (16%)
PP2Cc 461..655 CDD:294085 9/46 (20%)
gcy-32NP_506452.5 HNOB 3..167 CDD:285002
HNOBA 226..440 CDD:285003 42/224 (19%)
CYCc 419..608 CDD:214485 22/135 (16%)
Guanylate_cyc 452..627 CDD:278633 17/96 (18%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2114
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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