DRSC/TRiP Functional Genomics Resources

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Protein Alignment Phlpp and acy-4

DIOPT Version :9

Sequence 1:NP_001260558.1 Gene:Phlpp / 35178 FlyBaseID:FBgn0032749 Length:954 Species:Drosophila melanogaster
Sequence 2:NP_504486.4 Gene:acy-4 / 178949 WormBaseID:WBGene00000071 Length:1013 Species:Caenorhabditis elegans


Alignment Length:372 Identity:71/372 - (19%)
Similarity:133/372 - (35%) Gaps:97/372 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly    69 YLTQLEVCENEMEVLDLSSL-AQLETLKCSRNKLMELIING-TNLQTLVADHNYLHNISTTNTHP 131
            :|..|.:|...:.:..||.. |:...|.|..:.:..:||:. |:::|.|   .||...||.:..|
 Worm   118 WLKSLILCILTLVISILSFFHAKRTELVCIASIISCVIISACTSMRTSV---TYLLIFSTYSLLP 179

  Fly   132 VPLKLQRIDISHNNFSELPNWVGACASLTAINASHNRLNNVAVLLRNYRITELVSL--DLAY--N 192
            :...|.........|  |..::|.   |...|...:      ::|....:..||::  .|.|  .
 Worm   180 MSFMLMIFSTFALTF--LVAFIGV---LMDYNVGFD------IILTRVMMVILVNVVGSLVYYPT 233

  Fly   193 DLKQLDQFPEGFSSIRSLQLQSNELPSLPDNFFAVTHARLETLNVSCNKLSTLPRYEQNNHAALV 257
            :..|...|.|....::|..|...|:           |.:.:.|      |:.||:    |.|..|
 Worm   234 EFVQRKTFHETRKCVQSRMLLDKEM-----------HRQEKIL------LAVLPK----NIAFEV 277

  Fly   258 NLSLAGNHLNDSIFEPLHNAAKLRVLHLAYNRIGVLPAACVRNWPELEI---------------- 306
            ...:...|             :.|:.|..|          :|.:.::.|                
 Worm   278 KKDMQETH-------------EERMFHKIY----------IRKYEDISILFADICGFTNLASEYN 319

  Fly   307 ---LVLSGNMLQQLPEEVATLGQ---LRVLRCCNNLLLCTPQLAKLAMLKVLDLSHNHLDRVNLL 365
               |||..|.|....::||::.|   :::|..|...:...|:..|...:..:::..:.::.:.|:
 Worm   320 PKDLVLMLNELFARFDKVASIHQCMRIKILGDCYYCVCGVPEYQKNHAINTVEMGRDMIEAIRLV 384

  Fly   366 ALVPSRNLKYLDLSGNLQLQVDEQQFKV-CQSQSQRHWSLVDVSGNN 411
                 |.:..:    |:.::|.....|. |.....:.|.. ||..|:
 Worm   385 -----REMTLV----NVNMRVGIHTGKAHCGVLGLKKWQF-DVWSND 421

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PhlppNP_001260558.1 leucine-rich repeat 91..110 CDD:275380 4/19 (21%)
LRR_8 109..169 CDD:290566 14/59 (24%)
leucine-rich repeat 111..135 CDD:275380 7/23 (30%)
leucine-rich repeat 136..158 CDD:275380 4/21 (19%)
leucine-rich repeat 159..183 CDD:275380 3/23 (13%)
leucine-rich repeat 184..209 CDD:275380 7/28 (25%)
LRR_8 205..266 CDD:290566 11/60 (18%)
leucine-rich repeat 210..230 CDD:275380 2/19 (11%)
leucine-rich repeat 232..255 CDD:275380 5/22 (23%)
LRR_RI <256..410 CDD:238064 28/176 (16%)
leucine-rich repeat 256..276 CDD:275380 2/19 (11%)
LRR_8 279..359 CDD:290566 17/101 (17%)
leucine-rich repeat 280..303 CDD:275380 4/22 (18%)
leucine-rich repeat 304..348 CDD:275380 13/65 (20%)
leucine-rich repeat 349..372 CDD:275380 1/22 (5%)
PP2Cc 461..655 CDD:294085
acy-4NP_504486.4 AC_N <50..291 CDD:292831 45/220 (20%)
CYCc 260..451 CDD:214485 35/205 (17%)
Guanylate_cyc 293..448 CDD:278633 25/149 (17%)
CYCc 778..984 CDD:214485
Guanylate_cyc 807..1003 CDD:278633
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2114
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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