DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Phlpp and soc-2

DIOPT Version :9

Sequence 1:	NP_001260558.1	Gene:	Phlpp / 35178	FlyBaseID:	FBgn0032749	Length:	954	Species:	Drosophila melanogaster
Sequence 2:	NP_001293758.1	Gene:	soc-2 / 177286	WormBaseID:	WBGene00004929	Length:	631	Species:	Caenorhabditis elegans

Alignment Length:	458	Identity:	121/458 - (26%)
Similarity:	190/458 - (41%)	Gaps:	79/458 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLKATRKQADPYKSKLKVSASHSGPHPLPV-EVTAAEEEQAATFGQTSPQKLSLKGSQLGGSILI 64
            :||...|..:....:|.:|:......|.|: |:|...|    .|  ....||:...:::|..:
Worm   135 LLKEFHKCKEAQDQRLDLSSIEITSIPSPIKELTQLTE----LF--LYKNKLTCLPTEIGQLV-- 191

  Fly    65 GNYNYLTQLEVCENEMEVL--DLSSLAQLETLKCSRNKLME---LIINGTNLQTL-------VAD 117
                .|.:|.:.||.:..|  .|:||..||||....|||.|   :|....:|:||       ||.
Worm   192 ----NLKKLGLSENALTSLPDSLASLESLETLDLRHNKLTEVPSVIYKIGSLETLWLRYNRIVAV 252

  Fly   118 HNYLHNISTTNTHPVPLKLQRIDISHNNFSELPNWVGACASLTAINASHNRLNNVAVLLRNYRIT 182
            ...:.|:|         ||:.:|:..|...|||:.:|...||.....|:|.|..|...:.:..
Worm   253 DEQIGNLS---------KLKMLDVRENKIRELPSAIGKLTSLVVCLVSYNHLTRVPEEIGDCH-- 306

  Fly   183 ELVSLDLAYNDLKQLDQ--------------------FPEGFSSIRSLQ---LQSNELPSLPDNF 224
            .|..|||.:|||.:|..                    .|....|.:.|:   ::||.|..||.|.
Worm   307 SLTQLDLQHNDLSELPYSIGKLVNLVRIGIRYNKIRCIPSELESCQQLEEFIVESNHLQLLPPNL 371

  Fly   225 FAVTHARLETLNVSCNKLSTLPRYEQNNHAALVNLSLAGNHLNDSIFEPLHNAAKLRVLHLAYNR 289
            ..:. .::.|:|:|.|:|:..|........:.|.:::..|.::.........|.:|..|:|..|.
Worm   372 LTML-PKIHTVNLSRNELTAFPAGGPQQFVSTVTINMEHNQISKIPIGIFSKATRLTKLNLKENE 435

  Fly   290 IGVLPAACVRNWPELEILVLSGNMLQQLPEEVATLGQLRVLRCCNNLLLCTP-QLAKLAMLKVLD 353
            :..||.. :.:|..:..|.||.|.|:.|||::..|..|.:|...||.|...| |:..|..|:.||
Worm   436 LVSLPLD-MGSWTSITELNLSTNQLKVLPEDIEKLVNLEILVLSNNQLKKLPNQIGNLNKLRELD 499

  Fly   354 LSHNHLDRVNLLALVPS-----RNLKYLDLSGNLQLQVDEQQFKVCQSQSQRHWSLVDVSGNNRA 413
            |..|.|:      .||:     ::|..|.:..|..|.:......:|..|..|      :..||..
Worm   500 LEENELE------TVPTEIGFLQHLTKLWVQSNKILTLPRSIGNLCSLQDLR------LGENNLT 552

  Fly   414 ALP 416
            |:|
Worm   553 AIP 555

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phlpp	NP_001260558.1	leucine-rich repeat	91..110	CDD:275380	9/21 (43%)
		LRR_8	109..169	CDD:290566	19/66 (29%)
		leucine-rich repeat	111..135	CDD:275380	7/30 (23%)
		leucine-rich repeat	136..158	CDD:275380	7/21 (33%)
		leucine-rich repeat	159..183	CDD:275380	5/23 (22%)
		leucine-rich repeat	184..209	CDD:275380	10/44 (23%)
		LRR_8	205..266	CDD:290566	16/63 (25%)
		leucine-rich repeat	210..230	CDD:275380	7/22 (32%)
		leucine-rich repeat	232..255	CDD:275380	6/22 (27%)
		LRR_RI	<256..410	CDD:238064	42/159 (26%)
		leucine-rich repeat	256..276	CDD:275380	2/19 (11%)
		LRR_8	279..359	CDD:290566	29/80 (36%)
		leucine-rich repeat	280..303	CDD:275380	7/22 (32%)
		leucine-rich repeat	304..348	CDD:275380	17/44 (39%)
		leucine-rich repeat	349..372	CDD:275380	8/27 (30%)
		PP2Cc	461..655	CDD:294085
soc-2	NP_001293758.1	leucine-rich repeat	148..169	CDD:275380	5/20 (25%)
		leucine-rich repeat	170..192	CDD:275380	5/33 (15%)
		LRR_RI	<192..274	CDD:238064	28/90 (31%)
		LRR_8	192..249	CDD:290566	20/56 (36%)
		leucine-rich repeat	193..215	CDD:275380	8/21 (38%)
		leucine-rich repeat	216..238	CDD:275380	9/21 (43%)
		LRR_8	238..318	CDD:290566	26/90 (29%)
		leucine-rich repeat	239..261	CDD:275380	7/30 (23%)
		leucine-rich repeat	262..284	CDD:275380	7/21 (33%)
		leucine-rich repeat	285..307	CDD:275380	5/23 (22%)
		leucine-rich repeat	308..330	CDD:275380	8/21 (38%)
		LRR_RI	327..553	CDD:238064	59/239 (25%)
		leucine-rich repeat	331..353	CDD:275380	2/21 (10%)
		leucine-rich repeat	354..375	CDD:275380	7/20 (35%)
		leucine-rich repeat	402..425	CDD:275380	3/22 (14%)
		leucine-rich repeat	449..471	CDD:275380	9/21 (43%)
		leucine-rich repeat	472..517	CDD:275380	16/50 (32%)
		LRR_8	517..572	CDD:290566	11/45 (24%)
		leucine-rich repeat	541..563	CDD:275380	6/21 (29%)
		leucine-rich repeat	588..611	CDD:275380
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R9772
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940