DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Phlpp and acy-1

DIOPT Version :9

Sequence 1:	NP_001260558.1	Gene:	Phlpp / 35178	FlyBaseID:	FBgn0032749	Length:	954	Species:	Drosophila melanogaster
Sequence 2:	NP_497970.1	Gene:	acy-1 / 175622	WormBaseID:	WBGene00000068	Length:	1253	Species:	Caenorhabditis elegans

Alignment Length:	790	Identity:	144/790 - (18%)
Similarity:	232/790 - (29%)	Gaps:	315/790 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 KATRKQADPYKSKLKVSASHSGPHPLPVEVTAAEEEQAATFGQTSPQKLSLKGSQLGGS--ILIG 65
            |:|.||  .:..|||:  :|:..:|:         ..||..|              |||  |.:.
Worm   530 KSTLKQ--KWAEKLKM--NHTNSYPM---------RAAAREG--------------GGSLRIKLA 567

  Fly    66 NYNYLTQL------EVC--ENEMEVLDLSSLA--------------------------------Q 90
            ..|..|||      .:|  |:..:...|.:||                                :
Worm   568 ERNRSTQLLPKESNSICIMEDNRKSASLQALATNNFNGSNTDTNNTYSERGVAGSVSKKSVAGSE 632

  Fly    91 LETLKCSRNKLMELIINGTN--------LQTLVADHNYLHNISTTNTHPVPLKLQRIDISHNNFS 147
            ..::|.||:..::|.:...|        |.|.::.|   ||.::         |.|.| :.|||.
Worm   633 SNSIKGSRSSGLQLSLQDGNSDLNSVGGLDTAISHH---HNAAS---------LTRFD-TDNNFD 684

  Fly   148 E-----------------------LPNW-----------------VGACASLTAINASHNRLNN- 171
            :                       |..|                 |.:....||....|...:.
Worm   685 QRLAMVIGQGEGGFDKGFWNHHDSLNKWTLRFNEKDVEEEYRAHFVDSSERYTASKKGHVERHKD 749

  Fly   172 -----------VAVLLRNYRITELVSLDLAYNDLKQLDQFPEGFSSIRSLQLQSNELPSLPDNF- 224
                       ....:..||.:. |.:|:....|..:........|:|...|      ||...|
Worm   750 LMEQGGEKDGITGSTVNKYRYSG-VFIDIIVATLIFVISGAVAIMSVRPFPL------SLIAYFP 807

  Fly   225 FAVTHARLETLNVSCNKLST----------LPRYEQNNHAALVNLSLAGNHLNDSIFEPLHNAAK 279
            ||.....|..:.:....|:.          :||:       |:.|.|        ||.|:..|..
Worm   808 FAAAILILTIVLIGLPLLARKKSFQCANQWMPRH-------LIGLLL--------IFLPIGVAIC 857

  Fly   280 LRVL-------------HLAYNRIGVLP--AAC----VRNWPELEILVLSGNM-----------L 314
            :..|             .||::.:.:|.  |.|    :..||:....|..|.:           |
Worm   858 IMPLCQSGDCANVILNYRLAFSYVTILAIFAHCNFSQLAAWPKTTAAVFIGLLHIAGVFYCEFNL 922

  Fly   315 QQLPEEVATLGQLRVLRCCNNLLLCTPQLAK-------LAMLKVLDLSHNH----------LDRV 362
            :.|.||..|         ||...:..|.:.|       |.......||.:.          ||.:
Worm   923 KHLVEEQDT---------CNVTAIMIPPIRKGLNYTIALNSTSARTLSQDFGSPLFIWELLLDVI 978

  Fly   363 NLLALVPSRNLKY-----LDLSGNLQLQVDEQQFKVCQSQSQRHWSLVDVSGNNRAALPTTKIRQ 422
            ..:.||...|.::     :...|::|.:.|.::.::.:.|:.  |.|     ||  .:|...:..
Worm   979 LSIVLVAFLNYQFETAFRMSFFGDVQARRDTERMQIVRDQAD--WLL-----NN--VIPAHAVES 1034

  Fly   423 VSAQRNQNKTSGPWTMGFAETPGSGDCRKLSVYQ---------LRAAN--YGGSDEAL----YGM 472
            :......::......:.||......|     :|:         ||..|  .|..||.|    :..
Worm  1035 LKTDTKYSENHETVGVLFASITNWND-----MYEENFEGGREFLRVLNEVIGDFDELLDRPDFTH 1094

  Fly   473 FEALEGRGRAAQEMSHLVPDLMKQ--------EQMVKDSAV----------RDYMKFTLLA---- 515
            .|.::..|.|....|.|.|:..|.        .||| |.|:          .|.:.|..:.
Worm  1095 IEKIKTIGPAYMAASGLNPERKKNMLHPKEHLYQMV-DFALAVQHVLSVFNEDLLNFDFVCKLGL 1158

  Fly   516 --AQQQCGSVRSAALFH------------------LTRTRAPSKVRPLKSKRYVLRMAS------ 554
              .....|.:.:..|::                  |.|.:.....|.....||......
Worm  1159 NIGPVTAGVIGTTKLYYDIWGDTVNIASRMYSTGVLNRIQVSQHTREYLLDRYEFEFRDHIEVKG 1223

  Fly   555 -TGGLDAYLI 563
             .||:|.||:
Worm  1224 IDGGMDTYLL 1233

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phlpp	NP_001260558.1	leucine-rich repeat	91..110	CDD:275380	4/18 (22%)
		LRR_8	109..169	CDD:290566	18/107 (17%)
		leucine-rich repeat	111..135	CDD:275380	5/23 (22%)
		leucine-rich repeat	136..158	CDD:275380	9/61 (15%)
		leucine-rich repeat	159..183	CDD:275380	5/35 (14%)
		leucine-rich repeat	184..209	CDD:275380	4/24 (17%)
		LRR_8	205..266	CDD:290566	15/71 (21%)
		leucine-rich repeat	210..230	CDD:275380	6/20 (30%)
		leucine-rich repeat	232..255	CDD:275380	4/32 (13%)
		LRR_RI	<256..410	CDD:238064	40/205 (20%)
		leucine-rich repeat	256..276	CDD:275380	6/19 (32%)
		LRR_8	279..359	CDD:290566	22/126 (17%)
		leucine-rich repeat	280..303	CDD:275380	7/41 (17%)
		leucine-rich repeat	304..348	CDD:275380	12/61 (20%)
		leucine-rich repeat	349..372	CDD:275380	6/32 (19%)
		PP2Cc	461..655	CDD:294085	31/158 (20%)
acy-1	NP_497970.1	MreD	127..>223	CDD:294686
		CYCc	297..469	CDD:214485
		Guanylate_cyc	317..503	CDD:278633
		SDF	<773..982	CDD:294387	46/238 (19%)
		CYCc	1016..1215	CDD:214485	38/213 (18%)
		Guanylate_cyc	1041..1235	CDD:278633	37/199 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900