DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Phlpp and gcy-12

DIOPT Version :9

Sequence 1:NP_001260558.1 Gene:Phlpp / 35178 FlyBaseID:FBgn0032749 Length:954 Species:Drosophila melanogaster
Sequence 2:NP_494995.2 Gene:gcy-12 / 173902 WormBaseID:WBGene00001538 Length:1679 Species:Caenorhabditis elegans


Alignment Length:962 Identity:170/962 - (17%)
Similarity:307/962 - (31%) Gaps:336/962 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly     6 RKQADPY----KSKLKV---------SASHSGPHPLPVEVTAAEEEQAATFGQTSPQKLSLKGSQ 57
            |..:|||    .|.|:|         :..|..|:..| |....:.:....|.|...|.:.     
 Worm   906 RVYSDPYFRPDTSDLEVQNYVKEVMAACWHHDPYQRP-EFKTIKNKLKPLFHQIYKQNIM----- 964

  Fly    58 LGGSILIGNYNYLTQLE--VCENEMEVLDLSSLAQLETLKCSRNKLMELIINGTNLQTLVADHNY 120
              ..:::....|.||||  |.|..:|:.|....:|         .|::.::..:..:.|:|..:.
 Worm   965 --DHMVLMMEKYQTQLEDLVDERTIELKDEQRRSQ---------HLLQRMLPSSVAEQLLAGQDV 1018

  Fly   121 LHNISTTNTHPVPLKLQRIDISHNNFSELPNWVGACASLTAINASHNRLNNVAVLLRNYRITELV 185
            :     ....| |:.:...||.  .|:.:.........:|.:|..:...:::   :|.|.:.::.
 Worm  1019 I-----PEAFP-PVTIYFSDIV--GFTTISGESTPMEVVTFLNKLYTLFDSI---IRRYDVYKVE 1072

  Fly   186 SLDLAYNDLKQLDQFPEGFSSIRSLQLQSNELPSLPDNF------FAVTHARLETLNVSCNKLS- 243
            ::..||..:..:.|:       ::::..:.::..:..:.      |::.|...|.|.:.....: 
 Worm  1073 TIGDAYMVVSGVPQY-------KTMEYHAEQIAMMAIHILSAVRSFSIPHRSCEPLMIRIGMHTG 1130

  Fly   244 ---------TLPRYEQNNHAALVNLSLAGNHLND-SIFEPLHNAAKLRVLHLAYNRIGVLP---- 294
                     |:|||           :|.|:.:|. |..|  .|...||: |.:.:...||.    
 Worm  1131 PCVAGVVGKTMPRY-----------TLFGDTVNTASRME--SNGEALRI-HCSSSTQKVLTSIDQ 1181

  Fly   295 --------AACVRNWPELEILVLSGNMLQQLPEEVATLGQLRVLRCCNNLLLCTPQLAKLAMLKV 351
                    :..::...::....|:|....:..|.:.                             
 Worm  1182 GFLLEERGSLAIKGKGQMTTYWLNGRAGYEFTETIE----------------------------- 1217

  Fly   352 LDLSHNHLDRVNLLALVPSRNLKYLDLSGNLQLQVDEQQFKVCQSQSQRHWSLVDVSGNNRAALP 416
                    |::.:..:.|..|||....|                      |.   |:..:..:|.
 Worm  1218 --------DKMVVPDIFPRPNLKNRGSS----------------------WG---VNRESSLSLA 1249

  Fly   417 TTKIRQV----SAQRNQNKTSGPWTMGFAETPGSGDCRKLSVYQLRAANYGGSDEALYGMFEALE 477
            |.|..|:    ||..|:|...                   .:|..:..|.||           ..
 Worm  1250 TEKSSQIMKRQSAAMNRNNQD-------------------VIYYNQPLNSGG-----------FT 1284

  Fly   478 GRGRAAQEMSHLVPDLMKQEQMVKDSAVRDYMKFTLLAAQQQCGSVRSAALFHLTRTRAPSKVRP 542
            .||.:.:||..|..:  .:|.::..||       :||.::.. |..:|.|          ||...
 Worm  1285 SRGTSNREMPKLYEE--DRESLLNQSA-------SLLGSRTS-GRKKSTA----------SKYNG 1329

  Fly   543 LKSKRYVLRMASTGGLDAYLIRRTSQLRLTKPDVIQKDQI------HSMPDPHVLELILSNDDEY 601
            ..:.|   ..:||       |...|..|.::|.....|.:      .|:||...|.|      |:
 Worm  1330 FSASR---MFSST-------ISNASSSRPSRPSTFDHDTLALRKRSTSLPDGEKLNL------EF 1378

  Fly   602 LVVGNAQLWSVMDIDRAAREIRKEENSLLAAKRLVDIAQSFAA-AESLSVI-VVRFRHLGTDVDH 664
            :...|.       .:.:...|....:||....|...|...::: :||.|.. ...:|.|.|....
 Worm  1379 IETTNL-------ANNSVPAIPNNISSLEPVFRKASIIDGYSSQSESPSQSQYPSYRDLTTGPHQ 1436

  Fly   665 LIRELKQ--SVRKK--------PQPVSLPLSSGSVCKRTCCDRSNACRHRAIEQEPLAGRSSPSG 719
            ..|.:..  .|||:        |..::...:|||:  .|.....::||......:..|..|||  
 Worm  1437 RKRGIATVFPVRKRSLSCGDAVPLKINENGASGSI--TTAVSPRSSCRALDPTMKLAARASSP-- 1497

  Fly   720 QSDRDLLAKDKDDEFVLAHARVLQEEQQLEMLDETESVSESVLSEEQFKCWEYMLEQNTQLLFDK 784
                        ||.      :.||:.:..::|     ::|:|:.                    
 Worm  1498 ------------DEI------IFQEDDEDALID-----NDSLLTS-------------------- 1519

  Fly   785 ELNTISKSFTKQRTVPNAIMAATVLPERNDFTSNLMRTVTNKFISTSTPQLPQPITTSVPLGSYH 849
              |..|||....||.|.        |.|.:..|.|              :.|.|:.        .
 Worm  1520 --NGNSKSEDVLRTCPQ--------PRRKNKHSFL--------------RDPSPLA--------K 1552

  Fly   850 QVKQAPPGHFGSALSF---QQAHSYGYNLFDAKPR--PKFHGGTVKRSAGPN 896
            :.:.|.|  ||....|   .:::.:..:..|:..|  .:|.||:|...|..|
 Worm  1553 RFRDASP--FGKKKPFWNSNKSNEHTSSPADSISRLFRRFRGGSVNEYADLN 1602

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PhlppNP_001260558.1 leucine-rich repeat 91..110 CDD:275380 1/18 (6%)
LRR_8 109..169 CDD:290566 9/59 (15%)
leucine-rich repeat 111..135 CDD:275380 4/23 (17%)
leucine-rich repeat 136..158 CDD:275380 3/21 (14%)
leucine-rich repeat 159..183 CDD:275380 4/23 (17%)
leucine-rich repeat 184..209 CDD:275380 3/24 (13%)
LRR_8 205..266 CDD:290566 10/76 (13%)
leucine-rich repeat 210..230 CDD:275380 1/25 (4%)
leucine-rich repeat 232..255 CDD:275380 6/32 (19%)
LRR_RI <256..410 CDD:238064 22/166 (13%)
leucine-rich repeat 256..276 CDD:275380 5/20 (25%)
LRR_8 279..359 CDD:290566 8/91 (9%)
leucine-rich repeat 280..303 CDD:275380 5/34 (15%)
leucine-rich repeat 304..348 CDD:275380 3/43 (7%)
leucine-rich repeat 349..372 CDD:275380 2/22 (9%)
PP2Cc 461..655 CDD:294085 41/201 (20%)
gcy-12NP_494995.2 PBP1_Speract_GC_like 123..545 CDD:107365
ANF_receptor 140..519 CDD:279440
PK_GC-A_B 648..957 CDD:270944 12/51 (24%)
TyrKc 688..951 CDD:197581 11/45 (24%)
HNOBA <967..1012 CDD:285003 11/53 (21%)
CYCc 991..1183 CDD:214485 36/232 (16%)
Guanylate_cyc 1018..1206 CDD:278633 32/219 (15%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2114
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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