DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Phlpp and Gucy2c

DIOPT Version :9

Sequence 1:	NP_001260558.1	Gene:	Phlpp / 35178	FlyBaseID:	FBgn0032749	Length:	954	Species:	Drosophila melanogaster
Sequence 2:	NP_001120790.1	Gene:	Gucy2c / 14917	MGIID:	106903	Length:	1072	Species:	Mus musculus

Alignment Length:	841	Identity:	152/841 - (18%)
Similarity:	281/841 - (33%)	Gaps:	251/841 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   136 LQRIDISHNNFSELPNW---VGACASLTAINASHNRLNNVAVL-------------LRNYRITEL 184
            |..::...:.|||:.|:   :........|...|||.:||.|:             |:....|.:
Mouse   206 LNALEAGVSYFSEVLNFKDVLRRSEQFQEILTGHNRKSNVIVMCGTPESFYDVKGDLQVAEDTVV 270

  Fly   185 VSLDLAYND-LKQLDQFPEGFSSIRSLQL---QSNELPSLPDNF------FAVTHARLETLNVSC 239
            :.:||..|. .::....||...::..|.|   ||....|:.:.|      |::  |.||...:..
Mouse   271 ILVDLFSNHYFEENTTAPEYMDNVLVLTLPSEQSTSNTSVAERFSSGRSDFSL--AYLEGTLLFG 333

  Fly   240 NKLSTL---------PRYEQ-------NNHAALVNLSLAGNHLNDSIFEPLH---NAAKLRVLHL 285
            :.|.|.         |::.:       ...|..|.|..:|:  .|:|...|:   :..|.:|| :
Mouse   334 HMLQTFLENGENVTGPKFARAFRNLTFQGFAGPVTLDDSGD--IDNIMSLLYVSLDTRKYKVL-M 395

  Fly   286 AY--NRIGVLPAACVRN--WPELEILVLSGNMLQQLPEEVATLGQLRVLRCCNNLLLCTPQLAKL 346
            .|  ::...:|.|...|  |..           .:||.:|..||...::.....|......|..:
Mouse   396 KYDTHKNKTIPVAENPNFIWKN-----------HKLPNDVPGLGPQILMIAVFTLTGILVVLLLI 449

  Fly   347 AMLKVLDLSHNHLDRVNLLALVPSRNLKYLDL--SGNLQLQVDE-------QQFKVCQSQSQRHW 402
            |:|.:.....:|..|....:.:||.|:..|:.  :.::.|::|:       |:.:.|: ..::..
Mouse   450 ALLVLRKYRRDHALRQKKWSHIPSENIFPLETNETNHISLKIDDDRRRDTIQRVRQCK-YDKKKV 513

  Fly   403 SLVDVSGNNRAALPTTKIRQVSAQRNQNKTSGPWTMGFAETPGSGDCRKL--SVYQLRAANYG-- 463
            .|.|:..::.......||                           |..||  |.|......||
Mouse   514 ILKDLKHSDGNFSEKQKI---------------------------DLNKLLQSDYYNLTKFYGTV 551

  Fly   464 GSDEALYGMFEALEGRGRAAQEMSHLV--PDLMKQEQMVKDSAVRDYMKFTLLAAQQQCGSVRSA 526
            ..|..::|:.|..| ||...:.::..:  ||....:...|.|.:.|..|              ..
Mouse   552 KLDTRIFGVVEYCE-RGSLREVLNDTISYPDGTFMDWEFKISVLNDIAK--------------GM 601

  Fly   527 ALFHLTRTRAPSKVRP---LKSKRYVLRMASTGGLDAYLIRR----TSQLRLTKPDVIQKDQIHS 584
            :..|.::.....:::.   :...|.|:::... |.::.|..:    |:...|.:..:.||..::|
Mouse   602 SYLHSSKIEVHGRLKSTNCVVDSRMVVKITDF-GCNSILPPKKDLWTAPEHLRQATISQKGDVYS 665

  Fly   585 MP---------------------------------DPHVLELILSNDDE-----YLVVGNAQLWS 611
            ..                                 .|...:|.|...||     ||:|.:.  |
Mouse   666 FAIIAQEIILRKETFYTLSCRDHNEKIFRVENSYGKPFRPDLFLETADEKELEVYLLVKSC--W- 727

  Fly   612 VMDIDRAAREIRKEENSLLAAKRLVDIAQSFAAAESLSVIVVRFRHLGTDVDHLIRELKQSVRKK 676
              :.|...|...|:..|.||  ::..:.........:..::.|.:....:::||:.|..|..:.:
Mouse   728 --EEDPEKRPDFKKIESTLA--KIFGLFHDQKNESYMDTLIRRLQLYSRNLEHLVEERTQLYKAE 788

  Fly   677 PQPVSLPLSSGSVCKRTCCDRSNACRHRAIEQEPLAGRSSPSGQSDRDLLAKDKDD--EFVLAHA 739
                                                               :|:.|  .|:|...
Mouse   789 ---------------------------------------------------RDRADHLNFMLLPR 802

  Fly   740 RVLQEEQQLEMLDETESVSESVLSEEQFKCWEYMLEQNTQLLFDKELNTISKSFT---------K 795
            .|::..::..:: |.|...|..:.......:..:.:.:|.:.....||.|.|||.         |
Mouse   803 LVVKSLKEKGIV-EPELYEEVTIYFSDIVGFTTICKYSTPMEVVDMLNDIYKSFDQIVDHHDVYK 866

  Fly   796 QRTVPNAIMAATVLPERN------DFTSNLMRTVTNKFIST----STPQLPQPITTSVPLG 846
            ..|:.:|.:.|:.||.||      |.:...:..::  ||.|    ..|.||..|...|..|
Mouse   867 VETIGDAYVVASGLPMRNGNRHAVDISKMALDILS--FIGTFELEHLPGLPVWIRIGVHSG 925

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phlpp	NP_001260558.1	leucine-rich repeat	91..110	CDD:275380
		LRR_8	109..169	CDD:290566	8/35 (23%)
		leucine-rich repeat	111..135	CDD:275380
		leucine-rich repeat	136..158	CDD:275380	5/24 (21%)
		leucine-rich repeat	159..183	CDD:275380	8/36 (22%)
		leucine-rich repeat	184..209	CDD:275380	5/25 (20%)
		LRR_8	205..266	CDD:290566	17/85 (20%)
		leucine-rich repeat	210..230	CDD:275380	7/28 (25%)
		leucine-rich repeat	232..255	CDD:275380	5/38 (13%)
		LRR_RI	<256..410	CDD:238064	35/169 (21%)
		leucine-rich repeat	256..276	CDD:275380	6/22 (27%)
		LRR_8	279..359	CDD:290566	17/83 (20%)
		leucine-rich repeat	280..303	CDD:275380	7/26 (27%)
		leucine-rich repeat	304..348	CDD:275380	7/43 (16%)
		leucine-rich repeat	349..372	CDD:275380	5/22 (23%)
		PP2Cc	461..655	CDD:294085	39/242 (16%)
Gucy2c	NP_001120790.1	Periplasmic_Binding_Protein_Type_1	35..415	CDD:299141	46/213 (22%)
		PKc_like	480..749	CDD:304357	52/319 (16%)
		STYKc	502..744	CDD:214568	47/290 (16%)
		CYCc	787..978	CDD:214485	33/193 (17%)
		Guanylate_cyc	814..1001	CDD:278633	28/115 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900