DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Phlpp and gucy2f

DIOPT Version :9

Sequence 1:	NP_001260558.1	Gene:	Phlpp / 35178	FlyBaseID:	FBgn0032749	Length:	954	Species:	Drosophila melanogaster
Sequence 2:	NP_571939.2	Gene:	gucy2f / 140424	ZFINID:	ZDB-GENE-011128-7	Length:	1107	Species:	Danio rerio

Alignment Length:	895	Identity:	164/895 - (18%)
Similarity:	287/895 - (32%)	Gaps:	288/895 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   158 SLTAINASHNRLNNVAVLLRNYRITELVSLDL-------AYNDLKQL-----DQFPEGFSSI--- 207
            ||..||.::..|.|.:.|.:.|.....::||.       |:|..|||     .|.||..|.:
Zfish   292 SLPYINITYYPLQNNSKLSKAYDAVLTITLDSDIMTFNEAFNAAKQLGELMVTQEPEQVSPLFGT 356

  Fly   208 --RSLQLQSNELPSL--PDNFFAVTHARLETLNVSCNKLS-TLPRYEQNN---HAALVNLSLAGN 264
              .||.|.:..:.:.  ...:.:.|:....|.|::....: .:...||.|   :..:::....|.
Zfish   357 IYNSLYLLAKSMHNARRAGRWLSGTNLAYFTRNITFTGFNQDIQTDEQGNGQTNYVILDTEAWGT 421

  Fly   265 HLNDSIFEPLHNAAKL---RVLHLAYNRIGVLPAACVRNWPE-------------------LEIL 307
            .|.......:.:...|   |.:|.....   .|.:..|.|.|                   :.::
Zfish   422 QLYRCFLVDMTSDLVLFAGRFIHFPGES---PPPSDSRCWFEDNAICTGGVDIIYVIIAFVIVLI 483

  Fly   308 VLSGNM---------LQQLPEEVATLGQLRVLRCCNNLLLCTPQLAKLAM-LKVLDLSHNHLDR- 361
            ::.|::         :||:.   ...|..|:|....:|....|||:|..: |:.|..|.::::.
Zfish   484 IVLGSIGLSLFIRRRIQQIQ---LIKGPNRILLTLEDLTFINPQLSKRKITLEDLSDSKSYIEEK 545

  Fly   362 --------VNLLALVPSRNLKYLDLSGNLQLQVDEQQFKVCQSQSQRHWSLVDVSGNNRAALPTT 418
                    ||.:|.....         ...:.|.|..:...:..::.|:..|..|        ||
Zfish   546 STGDRSRSVNSMATATHE---------TSNVAVYEGDWVWLKKFTEGHFKEVKQS--------TT 593

  Fly   419 KI-RQVSAQRNQNKTSGPWTMGFAETPGSGDCRKLSVYQLRAANYGGSDEALYGMFEALEGRGRA 482
            || .::...||:|  ..|: :||..     ||...::.         ::....|....|
Zfish   594 KIFTKMKDLRNEN--VNPF-LGFFT-----DCEMFAIV---------TEHCSRGSLHDL------ 635

  Fly   483 AQEMSHLVPDLMKQEQMVKDSAVRDYMKFTLLAAQQQCGSVRSAALFHLTRTRAPSKVRPLKSK- 546
                  |..|.:|.:.|.|.|.|.|.:|                .:.:|.....|.  ..|||:
Zfish   636 ------LRNDDVKLDWMFKSSLVLDLIK----------------GMKYLHHREFPH--GRLKSRN 676

  Fly   547 -----RYVLRMASTGGLDAYLIRRTSQLRLTKPDVIQKDQIHSMPDPHVLELILSNDDEYLVVGN 606
                 |:||::...|..:....::..:..|...|:
Zfish   677 CVVDGRFVLKITDYGYNEILETQKAPKETLPPEDL------------------------------ 711

  Fly   607 AQLWSVMDIDRAAREIRKEENSLLAAKRLVDIAQSFAAAESLSVIVVR---FRHLGTDVDHLIRE 668
              .|:      |...:|..|:......:    ...::.|..|..:|||   :..||...:.:||:
Zfish   712 --FWT------APEHLRDPESPRKGTYK----GDVYSFAIILQEVVVRGAPYCMLGLSPEEIIRK 764

  Fly   669 LKQSVRKKPQPVSLPLSSGSVCKRTCCDRSNACRHRAIEQEPLAGRSSPSGQ--SDRDLLAKDKD 731
            :     |||.|:..|..:.......|......|.....::.|      |..|  ....|:.|.|.
Zfish   765 V-----KKPPPMCRPTVAPDQAPLECIQLMKQCWSEQPDRRP------PFDQIFDQFKLINKGKK 818

  Fly   732 DEFVLAHARVLQE---------EQQLEMLDETESVSESVLSE-------EQFKCW-----EYM-- 773
            ...:.:..|:|::         .::.|.|:..:..:|.:|||       |..|..     ||.
Zfish   819 TNIIDSMLRMLEQYSSNLEDLIRERTEELEVEKQRTEKLLSEMLPPSVAEALKTGASVEPEYFDQ 883

  Fly   774 -------------------------LEQNTQLLFDKELNTISKSFTKQRTVPNAIMAATVLPERN 813
                                     |..:...|||..|.  |....|..|:.:|.|.|:.||::|
Zfish   884 VTIYFSDIVGFTTISSLSDPIEVVDLLNDLYSLFDAVLG--SHDVYKVETIGDAYMVASGLPKKN 946

  Fly   814 ---------DFTSNLMRTVTNKFISTSTPQLPQPITTSVPLGSYHQVKQAPPGHFGSALSFQQAH 869
                     :.:.|::.:| ..|.....|::|..|...:              |.|..:    |.
Zfish   947 GNKHAAEIANMSLNILSSV-GSFKMRHMPEVPVRIRIGI--------------HSGPCV----AG 992

  Fly   870 SYGYNLFDAKPRPKFHGGTVKRSAGPNSAYFGSLQRLMPYNFEYDFAVTQ 919
            ..|..:    ||....|.||..::...|..       :||....:.:..|
Zfish   993 VVGLTM----PRYCLFGDTVNTASRMESTG-------LPYRIHVNISTVQ 1031

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phlpp	NP_001260558.1	leucine-rich repeat	91..110	CDD:275380
		LRR_8	109..169	CDD:290566	4/10 (40%)
		leucine-rich repeat	111..135	CDD:275380
		leucine-rich repeat	136..158	CDD:275380	164/895 (18%)
		leucine-rich repeat	159..183	CDD:275380	7/23 (30%)
		leucine-rich repeat	184..209	CDD:275380	11/41 (27%)
		LRR_8	205..266	CDD:290566	11/71 (15%)
		leucine-rich repeat	210..230	CDD:275380	3/21 (14%)
		leucine-rich repeat	232..255	CDD:275380	5/26 (19%)
		LRR_RI	<256..410	CDD:238064	31/194 (16%)
		leucine-rich repeat	256..276	CDD:275380	2/19 (11%)
		LRR_8	279..359	CDD:290566	21/111 (19%)
		leucine-rich repeat	280..303	CDD:275380	6/25 (24%)
		leucine-rich repeat	304..348	CDD:275380	11/52 (21%)
		leucine-rich repeat	349..372	CDD:275380	6/31 (19%)
		PP2Cc	461..655	CDD:294085	31/202 (15%)
gucy2f	NP_571939.2	PBP1_sensory_GC_DEF_like	59..440	CDD:107366	31/147 (21%)
		PK_GC-2D	551..816	CDD:270945	66/381 (17%)
		HNOBA	<825..870	CDD:311573	9/44 (20%)
		CYCc	850..1042	CDD:214485	41/214 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900