DRSC/TRiP Functional Genomics Resources

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Protein Alignment Phlpp and AgaP_AGAP011947

DIOPT Version :9

Sequence 1:NP_001260558.1 Gene:Phlpp / 35178 FlyBaseID:FBgn0032749 Length:954 Species:Drosophila melanogaster
Sequence 2:XP_320584.4 Gene:AgaP_AGAP011947 / 1280722 VectorBaseID:AGAP011947 Length:1233 Species:Anopheles gambiae


Alignment Length:1049 Identity:231/1049 - (22%)
Similarity:373/1049 - (35%) Gaps:326/1049 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly    42 TF-GQTSPQKLSLKGSQLGGSILIG----NYNYLTQLEVCENEMEVLDLSSLAQLETLK---CSR 98
            || |..:.:.|.|.|:::..:.:||    :.:.|..|.:..|.:..|...|...|.:||   .:.
Mosquito   231 TFVGLPALKTLQLSGNKITDAGMIGRAVKDIHNLQVLRMDRNMISKLSEGSFVDLPSLKELYLND 295

  Fly    99 NKLMELIINGT-----NLQTLVADHNYLHNISTTNTHP--------------------------- 131
            |.:.| |.:|.     :|:.:..::|||..:     ||                           
Mosquito   296 NGITE-IFHGAFHRTPSLKLVHLENNYLRRV-----HPESFLQASGSGVEMMHLQQNEIGRVEEL 354

  Fly   132 ------VPLKLQRIDISHNNFSELPNWVGAC---ASLTAINASHNRLNNV------------AVL 175
                  :|: |:.:|:|||....:|  .||.   .:|..:..:.||:..:            .:.
Mosquito   355 RSLLDALPM-LRFLDLSHNKLEAIP--FGALRGHGTLEQLYLNQNRIRMIERDAFMAMPGLRELR 416

  Fly   176 LRN-----------YRITELVSLDLAYNDLKQLDQFPE---GFSSIRSLQLQSNELPSLPDNFFA 226
            |:|           :.:..|..:|::||..:::|  |.   |..|:|.|.:..|.|..:....| 
Mosquito   417 LQNNSLHDQLPMPFWNLPGLKGIDISYNSFRRMD--PNLLVGVPSLRRLDISGNTLSVIDAGAF- 478

  Fly   227 VTHA-RLETLNVSCNKLSTL--PRYEQNNHAALVNLSLAGNHLNDSIFEPLHNAAKLRVLHLAYN 288
             ||. .|||:|:|.|:||.:  ..:...||  :..|....|.|.:  |.|....|..|| :|..|
Mosquito   479 -THTPMLETVNISFNELSLIHSATFRDLNH--MFELDAGNNKLQE--FIPGLPVAVERV-NLHGN 537

  Fly   289 RIGVLP----AACVRNWPELEILVLSGNMLQQLPEEV-ATLGQLRVLRCCNNLLLCTP--QLAKL 346
            .|..||    |:.:.:.|.|.:|.:|.|.|.:||..| ....|||||....|.|....  .|:.|
Mosquito   538 MITQLPPPTTASQLWDLPNLRMLDISANQLTRLPRAVFKPTPQLRVLSLARNQLQSVDDGSLSGL 602

  Fly   347 AMLKVLDLSHNHLDRVNLLALVPSRNLKYLDLSGN-LQLQVDE--------QQFKVCQS------ 396
            :.|::|:|..|.:..::.....|..||:.|:|.|| :::.||.        :||...::      
Mosquito   603 SRLEILNLQDNRVLALHERCFSPLENLRELNLQGNRIEVLVDNLLDSNALLEQFDASRNSIVEIS 667

  Fly   397 ----QSQRHWSLVDVSGNNRAALPTT-----KIRQVSAQRNQNKTSGP-----WTMGFAETPGSG 447
                ::.|....:|:|.|....||.:     ::|::....||.....|     |           
Mosquito   668 PKAFRNSRSLQTLDLSSNQLRELPESLSGLAELRELDVSFNQLTELSPNVLVSW----------- 721

  Fly   448 DCRKLSVYQLRAANYGGSDEALYGMFEALEGRGRAAQEMSHLVPDLMKQEQMVKDSAVRDYMKFT 512
              |.|.  :|:.:|  .....|:      :|..|....:.:|  ||...|             .|
Mosquito   722 --RNLE--ELKVSN--NKVNQLH------QGSLRNLPLLQYL--DLSSNE-------------LT 759

  Fly   513 LLAAQQQCGSVRSAALFHLTR-TRAPSKVRPLKSKRYVLRMASTGGLDAYLIRRTSQLRLTKPDV 576
            ||    :.||:|:  |..|.. ..|.:|:..||.:.:    .....|.|..::: :.||...|  
Mosquito   760 LL----EHGSLRN--LPELQELVLADNKLSELKERVF----EDLPNLQAVHLQQ-NNLRYISP-- 811

  Fly   577 IQKDQIHSMPDPHVLELILSNDDEYLVVGNAQLWSVMD---IDRAAREIRK-EENSLLAAKRLVD 637
                 ......|.::.|.|| .:::..:.:..|.||.:   :|.....||| ..:.|.....||:
Mosquito   812 -----YSFFRSPSIVYLNLS-ANQFRSLDSVGLRSVRNLEVLDLTGNSIRKITPSPLRGLDWLVE 870

  Fly   638 I-----------AQSFAAAESLSVIVVRFRHLGTDVDHLIRELKQSVR---KKPQPV-------- 680
            :           .:.||....|.|:.:|...:....:.:.|.|:.::.   ....|:        
Mosquito   871 LKLDNNKICGIQGEPFATMPRLRVLSMRNNQMSRVPEPIFRSLRTNIAILDVDGNPLDCSCDMLW 935

  Fly   681 -------SLPLSSGSVCK-----------RTCCDRSNACRHRAIEQEPLAGRSSPSGQSDRDLLA 727
                   |..|..|..|:           ||.| :|.|             |::|||......|.
Mosquito   936 YMAWLQESRSLYPGPRCRDGKMLLDMRLSRTDC-QSGA-------------RTAPSGHQGDHPLT 986

  Fly   728 KDKDDEFVLAHARVLQEEQQLEMLDETE----------------------SVSESVLSEEQFKCW 770
            .|..|.||.|             ||..|                      |..:|....:|:..:
Mosquito   987 NDHGDVFVRA-------------LDYDECAGSENYELPPGPTPPFHAGSPSPGDSDYFYDQYVDY 1038

  Fly   771 EYMLEQNTQLLFDKELNTISKSFTKQRTVPNAIMAATVLPERNDFTSNLMRTVTNKFISTSTPQ- 834
            ...| .:|:|...:..|         .|.|   .|.....:|.::|:|.:....|||.....|. 
Mosquito  1039 PNAL-NDTRLANGQRFN---------NTTP---FAQDPQQDRRNYTTNFVDFNNNKFNQFQRPPG 1090

  Fly   835 -LPQPITTSVPLGSYHQVKQAPPGHFGSALSFQQAHSYGYNLFDAKPRP-----KFHGGTVKRSA 893
             .|.|    .||....|...:|...||                  .|.|     |..||...|:|
Mosquito  1091 GAPPP----PPLSPGDQDSGSPFTFFG------------------LPIPSLNIGKMFGGAAGRNA 1133

  Fly   894 GPNSAYFGS 902
            . |.|..||
Mosquito  1134 N-NRASGGS 1141

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PhlppNP_001260558.1 leucine-rich repeat 91..110 CDD:275380 7/26 (27%)
LRR_8 109..169 CDD:290566 17/100 (17%)
leucine-rich repeat 111..135 CDD:275380 7/56 (13%)
leucine-rich repeat 136..158 CDD:275380 8/24 (33%)
leucine-rich repeat 159..183 CDD:275380 5/46 (11%)
leucine-rich repeat 184..209 CDD:275380 8/27 (30%)
LRR_8 205..266 CDD:290566 20/63 (32%)
leucine-rich repeat 210..230 CDD:275380 5/19 (26%)
leucine-rich repeat 232..255 CDD:275380 10/24 (42%)
LRR_RI <256..410 CDD:238064 50/179 (28%)
leucine-rich repeat 256..276 CDD:275380 5/19 (26%)
LRR_8 279..359 CDD:290566 30/86 (35%)
leucine-rich repeat 280..303 CDD:275380 8/26 (31%)
leucine-rich repeat 304..348 CDD:275380 17/46 (37%)
leucine-rich repeat 349..372 CDD:275380 5/22 (23%)
PP2Cc 461..655 CDD:294085 43/209 (21%)
AgaP_AGAP011947XP_320584.4 leucine-rich repeat 73..94 CDD:275380
leucine-rich repeat 95..118 CDD:275380
LRR_RI <97..290 CDD:238064 15/58 (26%)
leucine-rich repeat 119..142 CDD:275380
LRR_8 141..196 CDD:290566
leucine-rich repeat 143..164 CDD:275380
leucine-rich repeat 165..188 CDD:275380
LRR_8 188..248 CDD:290566 6/16 (38%)
LRR_RI 199..495 CDD:238064 61/276 (22%)
leucine-rich repeat 214..237 CDD:275380 3/5 (60%)
leucine-rich repeat 238..263 CDD:275380 5/24 (21%)
LRR_8 263..322 CDD:290566 14/59 (24%)
leucine-rich repeat 264..287 CDD:275380 6/22 (27%)
leucine-rich repeat 288..311 CDD:275380 6/23 (26%)
leucine-rich repeat 312..337 CDD:275380 6/29 (21%)
leucine-rich repeat 338..363 CDD:275380 0/24 (0%)
LRR_8 364..422 CDD:290566 13/59 (22%)
leucine-rich repeat 364..387 CDD:275380 8/24 (33%)
leucine-rich repeat 388..411 CDD:275380 3/22 (14%)
LRR_8 410..468 CDD:290566 12/59 (20%)
leucine-rich repeat 412..435 CDD:275380 2/22 (9%)
leucine-rich repeat 436..459 CDD:275380 7/24 (29%)
LRR_8 458..518 CDD:290566 20/63 (32%)
leucine-rich repeat 460..483 CDD:275380 7/24 (29%)
LRR_8 484..567 CDD:290566 29/87 (33%)
leucine-rich repeat 484..507 CDD:275380 8/22 (36%)
leucine-rich repeat 508..556 CDD:275380 14/50 (28%)
LRR_RI 529..793 CDD:238064 75/312 (24%)
leucine-rich repeat 557..580 CDD:275380 8/22 (36%)
LRR_8 579..639 CDD:290566 20/59 (34%)
leucine-rich repeat 581..604 CDD:275380 8/22 (36%)
leucine-rich repeat 605..628 CDD:275380 5/22 (23%)
leucine-rich repeat 629..652 CDD:275380 7/22 (32%)
leucine-rich repeat 653..676 CDD:275380 2/22 (9%)
LRR_8 675..734 CDD:290566 15/75 (20%)
leucine-rich repeat 677..699 CDD:275380 5/21 (24%)
leucine-rich repeat 700..723 CDD:275380 5/35 (14%)
LRR_8 722..782 CDD:290566 20/90 (22%)
leucine-rich repeat 724..747 CDD:275380 6/32 (19%)
leucine-rich repeat 748..771 CDD:275380 11/43 (26%)
LRR_8 770..830 CDD:290566 14/72 (19%)
leucine-rich repeat 772..795 CDD:275380 5/26 (19%)
leucine-rich repeat 796..819 CDD:275380 5/30 (17%)
leucine-rich repeat 820..843 CDD:275380 6/23 (26%)
LRR_8 842..902 CDD:290566 12/59 (20%)
leucine-rich repeat 844..867 CDD:275380 5/22 (23%)
leucine-rich repeat 868..891 CDD:275380 4/22 (18%)
leucine-rich repeat 892..913 CDD:275380 4/20 (20%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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