DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Phlpp and AgaP_AGAP012161

DIOPT Version :9

Sequence 1:	NP_001260558.1	Gene:	Phlpp / 35178	FlyBaseID:	FBgn0032749	Length:	954	Species:	Drosophila melanogaster
Sequence 2:	XP_320372.4	Gene:	AgaP_AGAP012161 / 1280524	VectorBaseID:	AGAP012161	Length:	1199	Species:	Anopheles gambiae

Alignment Length:	571	Identity:	115/571 - (20%)
Similarity:	187/571 - (32%)	Gaps:	189/571 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   184 LVSLDLAYNDLKQLDQFPEGFSSIRSLQLQSNELPSLPDNFFAVTHARLETLNVSCNKLSTLPRY 248
            ::|....:|:......||. |:..|.           ||            |.:|.:.:|.|..|
Mosquito    76 MISYFCTHNETSNKKHFPT-FARTRP-----------PD------------LQISKSVVSLLLAY 116

  Fly   249 EQNNHAALVNLSLAGNHLNDSIFEPLHNAAKLRVLHLAYNRIGVLPAACVRNWPELEILVLSGNM 313
            .....:.|...|  .|...|::.|.|...  ||...:....:|        .|.::.....|.|.
Mosquito   117 NWTQVSFLYRAS--DNGELDAVAETLKTT--LRTASIRIRSVG--------TWTDIYHHGYSSNP 169

  Fly   314 LQQLPEEVATLGQLRVLRCCNNLLLCTPQLAKLAMLKVLDLSHNHLDRVNLLALVPSRNLKYLDL 378
            .::|.|:  |....|:                     .|.|.: |.:.:.||..:..|.|  ||.
Mosquito   170 FERLVED--TYEDTRI---------------------YLVLGY-HYEHIGLLVSLRRRGL--LDR 208

  Fly   379 SGNLQLQVDEQQFKVCQSQSQRHWSL--------VDVSGNNRAALPTTKIR------QVS-AQRN 428
            .....:.||..|:.........|..|        |:...:....:|:..:|      :|| :.|:
Mosquito   209 GDYFVVGVDIDQYDAALPTKYMHGLLQTTPDPDAVEAFRHYLGIVPSAPVRFEEFAVKVSWSARD 273

  Fly   429 QNKTSGPWTMG---FAETPGSGDCRKL----SVYQLRA-ANY------------------GGSDE 467
            :::.|......   :.|.|.......|    .|.|:|| |.|                  |||.:
Mosquito   274 RSRLSRRQRAAVNKYLELPPFNYRNALIFFGGVKQIRAEAAYLYDAVHLYANALMQVLLSGGSPK 338

  Fly   468 ALYGMFEALEGRGRAAQEMSHLVPDLMKQEQMVKDS--AVRDYMKFTLLAAQ--QQCGSVRSAAL 528
            ....:.||::||...: .|.:||        .:.::  |..:|   |:||.:  ...|:.....|
Mosquito   339 NGSAIIEAIKGRAYIS-AMGYLV--------HIDENGDATGNY---TILARKPVPSTGATNQYGL 391

  Fly   529 FHLTRTRAPSKVRPLKSKRYVLRMASTGGLDAYLIRRTSQLRLTKPDVIQKDQIHSMP---DPH- 589
            |.:.|..:|:          |.|:..:|        ..|::||.  |.|  |.:.|.|   :|.
Mosquito   392 FPIGRFSSPT----------VDRIPVSG--------VCSEIRLF--DTI--DWVGSGPPVAEPRC 434

  Fly   590 ---------------------------VLELILSNDDEYLVVGNAQLWSVMDIDRAAREIRKEEN 627
                                       |:.|:|..:..|....::.||.| |.    |||:..||
Mosquito   435 GFRGEKCISYTGEITGGIAGGALLLLGVVSLVLYRNWRYEQELDSLLWKV-DF----REIQMHEN 494

  Fly   628 SL-LAAKRLVDIAQSFAAAESLSVIVVRFRHLGTDVDHLIRELKQSVRKKP 677
            .. .|.:::..:          ||.|.| .|.......|||..:.|:...|
Mosquito   495 EKETAGQKMTRV----------SVCVCR-SHAYYSTHPLIRTSQVSLSSNP 534

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phlpp	NP_001260558.1	leucine-rich repeat	91..110	CDD:275380
		LRR_8	109..169	CDD:290566
		leucine-rich repeat	111..135	CDD:275380
		leucine-rich repeat	136..158	CDD:275380
		leucine-rich repeat	159..183	CDD:275380
		leucine-rich repeat	184..209	CDD:275380	5/24 (21%)
		LRR_8	205..266	CDD:290566	11/60 (18%)
		leucine-rich repeat	210..230	CDD:275380	2/19 (11%)
		leucine-rich repeat	232..255	CDD:275380	5/22 (23%)
		LRR_RI	<256..410	CDD:238064	31/161 (19%)
		leucine-rich repeat	256..276	CDD:275380	6/19 (32%)
		LRR_8	279..359	CDD:290566	12/79 (15%)
		leucine-rich repeat	280..303	CDD:275380	4/22 (18%)
		leucine-rich repeat	304..348	CDD:275380	6/43 (14%)
		leucine-rich repeat	349..372	CDD:275380	5/22 (23%)
		PP2Cc	461..655	CDD:294085	50/247 (20%)
AgaP_AGAP012161	XP_320372.4	ANF_receptor	2..372	CDD:279440	70/366 (19%)
		Periplasmic_Binding_Protein_Type_1	3..397	CDD:299141	77/394 (20%)
		PK_GC-A_B	523..806	CDD:270944	4/12 (33%)
		TyrKc	550..800	CDD:197581
		HNOBA	<815..860	CDD:285003
		CYCc	839..1033	CDD:214485
		Guanylate_cyc	866..1052	CDD:278633
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900