DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Phlpp and AgaP_AGAP012163

DIOPT Version :9

Sequence 1:	NP_001260558.1	Gene:	Phlpp / 35178	FlyBaseID:	FBgn0032749	Length:	954	Species:	Drosophila melanogaster
Sequence 2:	XP_320371.4	Gene:	AgaP_AGAP012163 / 1280523	VectorBaseID:	AGAP012163	Length:	1471	Species:	Anopheles gambiae

Alignment Length:	772	Identity:	134/772 - (17%)
Similarity:	256/772 - (33%)	Gaps:	266/772 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 KSKLKVSASHSGPHPLPV---------EVTAAEE---EQAATFGQTSPQKLSLKGSQLGGSILIG 65
            ||.|.|.||    .|||.         |.|..|.   :|.:.|.| ..:.:|:..:.|..|:.:
Mosquito   295 KSLLVVVAS----EPLPTFEAFTHKVREYTQKEPFFFKQPSLFHQ-FVKYVSIYAAYLYDSVKL- 353

  Fly    66 NYNYLTQLE-VCENEMEVLDLSSLAQLETLKCSRNKLMELIINGTN-LQTLVADHNYLHNISTTN 128
               |...|: :.:.|.:...|:|           :.:.::..|||. :||::.:..| |:::...
Mosquito   354 ---YAWALDKLLKEEQQHRPLTS-----------DVIRDVASNGTKIIQTIINNRTY-HSVAGAT 403

  Fly   129 THPVPLKLQRIDISHNNFSELPNWVGACASLTAINASHNRLNNVAVLLRNYRITELVSLDLAYND 193
                 :|:.....|..|||.|           |:........|.:        .|.....:|:..
Mosquito   404 -----IKIDDYGDSEGNFSVL-----------ALKREFYEEANFS--------CEFQMRPVAHFQ 444

  Fly   194 LKQLDQFPEGFSSIRSLQLQSNELPSL-----------PDNFFAVTHARLETLNVSCNKLSTLPR 247
            ::|    |:..:...  |.:::|:|..           |.:...:.......:|..|.|
Mosquito   445 MRQ----PQHLNDTN--QHRNDEIPEFKLSKVGNAIDWPGSDRPMDEPSCGFMNEHCMK------ 497

  Fly   248 YEQNNHAALVNLSLAGNHLNDSIFEPLHNAAKLRVLHLAYNRIGVLPAACVRNWP-ELEILVLSG 311
              .:.|  ::::.:||                  ||.|.....||:..:..|.|. ||||   .|
Mosquito   498 --DDTH--IMSMVVAG------------------VLALILFCAGVITMSIYRKWKIELEI---EG 537

  Fly   312 NMLQQLP---------EEVATLGQLRVL-------RCCNNLLLCTPQ----LAKLAMLK------ 350
            .:.:..|         |.|::..:|.:.       ||.|.:...|.:    :.::..||
Mosquito   538 LLWKIDPGDIKGYFNTEIVSSPSKLSLASAQSFGSRCSNQVFTPTARFRSVVVRIKELKFSRRKD 602

  Fly   351 -----------VLDLSHNHLDRVNLLALVPSRNLKYLD--LSGNLQLQVDEQQFK---------- 392
                       :.||.|::::......:.|.|.|...|  ..|:|...::.:..|
Mosquito   603 ISREIMKEMRLLRDLRHDNINSFIGACVEPMRILLVTDYCAKGSLYDIIENEDIKLDDLFIASLV 667

  Fly   393 --VCQSQSQRHWSLVDVSGNNRAALPTTKIRQVSAQRNQNKTSGPWTMGFAETPGSGDCRKLSVY 455
              :.::....|.|.::..||.:                                 |.:|...|.:
Mosquito   668 HDLIKAMIYIHSSALNYHGNLK---------------------------------SSNCVVTSRW 699

  Fly   456 QLRAANYGGSDEALYGMFEALEGRGRAAQEMSHLVPDLMKQEQMVKDSAVRDYMKFTLLAAQQQC 520
            .|:..::|..|.......|:: |..:..:.:....|:|::|.. |..:...|...|.::
Mosquito   700 MLQVTDFGLHDLRHCAENESI-GEHQHYRNLFWKSPELLRQPS-VYGTQKGDVYAFAII------ 756

  Fly   521 GSVRSAALFHLTRTRAPSKVRPLKSKRYVLRMASTGGLDAYLIRRTSQLRLTKPDVIQKDQIHSM 585
                   ||.:...|.|.....|:.|..:                              |::.::
Mosquito   757 -------LFEIIGRRGPFGYTELEPKEII------------------------------DRVKAL 784

  Fly   586 PDPHV------LELILSNDD--EYLVVGNAQLWSV-MDIDRAAREIRKEENSLLAAK------RL 635
            |:|..      :|.::.|::  :|::......|.. .|:......||.....:...|      ::
Mosquito   785 PEPGKDPFRPDIESVIENENVSDYVINCIRDCWDENADLRPDFPNIRNRLKRMRGGKSKNIMDQM 849

  Fly   636 VDIAQSFAAAESLSVIVVRFRHLGTDVDHLIRELKQSV-----RKKPQPVSLPLSSG 687
            :::.:.:  |.:|..||       .|...|:.|.|:..     |..||||:..|:.|
Mosquito   850 MEMMEKY--ANNLEEIV-------QDRTRLLCEEKRKTEDLLHRMLPQPVAEKLTKG 897

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phlpp	NP_001260558.1	leucine-rich repeat	91..110	CDD:275380	2/18 (11%)
		LRR_8	109..169	CDD:290566	12/60 (20%)
		leucine-rich repeat	111..135	CDD:275380	4/23 (17%)
		leucine-rich repeat	136..158	CDD:275380	5/21 (24%)
		leucine-rich repeat	159..183	CDD:275380	2/23 (9%)
		leucine-rich repeat	184..209	CDD:275380	3/24 (13%)
		LRR_8	205..266	CDD:290566	10/71 (14%)
		leucine-rich repeat	210..230	CDD:275380	4/30 (13%)
		leucine-rich repeat	232..255	CDD:275380	4/22 (18%)
		LRR_RI	<256..410	CDD:238064	36/205 (18%)
		leucine-rich repeat	256..276	CDD:275380	2/19 (11%)
		LRR_8	279..359	CDD:290566	25/117 (21%)
		leucine-rich repeat	280..303	CDD:275380	7/23 (30%)
		leucine-rich repeat	304..348	CDD:275380	12/63 (19%)
		leucine-rich repeat	349..372	CDD:275380	6/39 (15%)
		PP2Cc	461..655	CDD:294085	31/208 (15%)
AgaP_AGAP012163	XP_320371.4	Periplasmic_Binding_Protein_Type_1	24..443	CDD:299141	40/192 (21%)
		ANF_receptor	46..421	CDD:279440	36/162 (22%)
		PK_GC-A_B	555..840	CDD:270944	52/362 (14%)
		Pkinase	569..832	CDD:278497	49/340 (14%)
		HNOBA	<848..894	CDD:285003	13/54 (24%)
		CYCc	873..1065	CDD:214485	9/25 (36%)
		Guanylate_cyc	900..1086	CDD:278633
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900