DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Phlpp and TOLL6

DIOPT Version :9

Sequence 1:	NP_001260558.1	Gene:	Phlpp / 35178	FlyBaseID:	FBgn0032749	Length:	954	Species:	Drosophila melanogaster
Sequence 2:	XP_320172.2	Gene:	TOLL6 / 1280328	VectorBaseID:	AGAP012387	Length:	1459	Species:	Anopheles gambiae

Alignment Length:	434	Identity:	117/434 - (26%)
Similarity:	183/434 - (42%)	Gaps:	83/434 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 EEQAATFGQTSPQKLSLKGSQLGGSILIGNYNYLTQLEVCENEMEVLDLS-------------SL 88
            |.:|..||||                               ..:||||||             ||
Mosquito   161 EIEADAFGQT-------------------------------RNLEVLDLSTNNIWSLPDHLFCSL 194

  Fly    89 AQLETLKCSRNKLM---ELIINGTNLQTLVADHNYLHNISTTNTHPV--PLKLQRIDISHNNFSE 148
            :.|.:|..|.|:|.   :|......::..|....:..|.|.:...||  .|.|:.:|:|.|:|..
Mosquito   195 SGLRSLNISSNRLQDVNDLGFREKGVKDEVESEGHKTNSSGSVAPPVSCALDLEDLDVSRNHFVL 259

  Fly   149 LP-NWVGACASLTAINASHNRLNNVAVLLRNYRITELVSLDLAYNDLKQL--DQFPEGFSSIRSL 210
            || ...|....|..:....|.::.|.....: .:.||..|||:.|.|..|  |.|.:...||:.:
Mosquito   260 LPAAGFGMLKRLKMLKIHDNEISMVGDKALS-GLKELQILDLSSNKLVALPTDLFRDPAQSIQEI 323

  Fly   211 QLQSNELPSLPDNFFAVTHARLETLNVSCNKLSTLPRYEQNNHAALVN---LSLAGN---HLNDS 269
            .||:|.:..|....|:... :|:.|::|.|:| |.....::..|.|:.   |:||.|   .|...
Mosquito   324 YLQNNSISVLSPGLFSKLE-QLQALDLSQNQL-TSAWVNRDTFAGLIRLVLLNLASNKITKLESE 386

  Fly   270 IFEPLHNAAKLRVLHLAYNRIGVLPAACVRNWPELEILVLSGNMLQQLPE-EVATLGQLRVLRCC 333
            ||..|:.   |::|:|.:|::.::.|........|..|:||.|.|:.|.. .:..|..|.:|...
Mosquito   387 IFSDLYT---LQILNLRHNQLEIIAADTFSPMNNLHTLLLSHNKLKYLDAYSLNGLYALSLLSLD 448

  Fly   334 NNLLL-CTPQ-LAKLAMLKVLDLSHNHLDRVNLLALVPSRNLKYLDLSGNLQLQVDEQQFKVCQS 396
            ||.|. ..|: ....:.|:.|:|:.|.|.:|. |||...|.|:.:||..|....::|..|:...:
Mosquito   449 NNALTGVHPEAFRNCSSLQDLNLNGNELTQVP-LALKDMRLLRTVDLGENSISVIEEPGFRGMNN 512

  Fly   397 QSQRHWSLVDVSGN----NRAA---LPTTKIRQVSAQRNQNKTS 433
            .    :.|..:|.|    .|.|   ||:.:|..|:    :||.|
Mosquito   513 L----YGLRLISNNIENITRKAFKDLPSLQILNVA----RNKIS 548

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phlpp	NP_001260558.1	leucine-rich repeat	91..110	CDD:275380	6/21 (29%)
		LRR_8	109..169	CDD:290566	16/62 (26%)
		leucine-rich repeat	111..135	CDD:275380	5/25 (20%)
		leucine-rich repeat	136..158	CDD:275380	8/22 (36%)
		leucine-rich repeat	159..183	CDD:275380	3/23 (13%)
		leucine-rich repeat	184..209	CDD:275380	11/26 (42%)
		LRR_8	205..266	CDD:290566	19/66 (29%)
		leucine-rich repeat	210..230	CDD:275380	5/19 (26%)
		leucine-rich repeat	232..255	CDD:275380	6/22 (27%)
		LRR_RI	<256..410	CDD:238064	46/162 (28%)
		leucine-rich repeat	256..276	CDD:275380	9/25 (36%)
		LRR_8	279..359	CDD:290566	23/82 (28%)
		leucine-rich repeat	280..303	CDD:275380	5/22 (23%)
		leucine-rich repeat	304..348	CDD:275380	14/46 (30%)
		leucine-rich repeat	349..372	CDD:275380	9/22 (41%)
		PP2Cc	461..655	CDD:294085
TOLL6	XP_320172.2	LRR_RI	94..355	CDD:238064	59/227 (26%)
		leucine-rich repeat	119..142	CDD:275380
		LRR_8	<162..207	CDD:290566	17/75 (23%)
		leucine-rich repeat	173..196	CDD:275380	8/22 (36%)
		LRR_8	247..305	CDD:290566	17/58 (29%)
		leucine-rich repeat	247..270	CDD:275380	8/22 (36%)
		leucine-rich repeat	271..294	CDD:275380	3/23 (13%)
		LRR_8	293..354	CDD:290566	21/61 (34%)
		leucine-rich repeat	295..319	CDD:275380	9/23 (39%)
		LRR_RI	298..549	CDD:238064	78/265 (29%)
		leucine-rich repeat	320..343	CDD:275380	6/23 (26%)
		leucine-rich repeat	344..369	CDD:275380	8/25 (32%)
		LRR_8	369..428	CDD:290566	18/61 (30%)
		leucine-rich repeat	370..393	CDD:275380	8/22 (36%)
		leucine-rich repeat	394..417	CDD:275380	5/22 (23%)
		LRR_8	417..476	CDD:290566	18/58 (31%)
		leucine-rich repeat	418..441	CDD:275380	8/22 (36%)
		leucine-rich repeat	442..465	CDD:275380	6/22 (27%)
		leucine-rich repeat	466..488	CDD:275380	9/22 (41%)
		leucine-rich repeat	489..512	CDD:275380	6/22 (27%)
		LRR_8	512..571	CDD:290566	12/45 (27%)
		leucine-rich repeat	513..534	CDD:275380	5/24 (21%)
		leucine-rich repeat	537..560	CDD:275380	5/16 (31%)
		LRR_8	560..616	CDD:290566
		leucine-rich repeat	561..583	CDD:275380
		LRR_8	630..687	CDD:290566
		leucine-rich repeat	631..676	CDD:275380
		leucine-rich repeat	829..852	CDD:275380
		LRR_8	851..911	CDD:290566
		LRR_RI	<852..962	CDD:238064
		leucine-rich repeat	853..876	CDD:275380
		leucine-rich repeat	877..900	CDD:275380
		LRR_8	900..958	CDD:290566
		leucine-rich repeat	901..924	CDD:275380
		TIR	1075..1208	CDD:214587
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910