DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Phlpp and AgaP_AGAP008848

DIOPT Version :9

Sequence 1:	NP_001260558.1	Gene:	Phlpp / 35178	FlyBaseID:	FBgn0032749	Length:	954	Species:	Drosophila melanogaster
Sequence 2:	XP_319590.4	Gene:	AgaP_AGAP008848 / 1279811	VectorBaseID:	AGAP008848	Length:	1025	Species:	Anopheles gambiae

Alignment Length:	1125	Identity:	209/1125 - (18%)
Similarity:	358/1125 - (31%)	Gaps:	364/1125 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 EVTAAEEEQAATFGQTSPQKLSLKGSQLGGSILIGNYNYLTQLEVCEN---EMEVLDLSSL-AQL 91
            ::..:::...::|.:|.|.  :.|.|:...::|:.|..:...:...::   .||:.....| |:|
Mosquito    45 DIAVSDKTVYSSFARTLPP--ATKVSKSVAALLLANNWHCFSIVASKHPAWSMEIAHAIELQAEL 107

  Fly    92 ETLKCSR------------NKLMELIIN---GTNLQTLVADH-------NYLHN---ISTTNTHP 131
            ..|..:.            .:|.|::.|   .|.:...|.||       ..|.|   :||.:...
Mosquito   108 NNLTVNHFRIYSDYIPSKIYELQEIVDNTYRNTRVYVFVGDHIEMVDFVRCLQNRKLLSTGDYIV 172

  Fly   132 VPLKLQRID------ISHNNFSEL-PNWVGACASLTAINASHNRLNNVAVLLRNYRITELVSLDL 189
            :.:..:..|      |...|:|:. ..::|        |:......|    .:.|...:...|..
Mosquito   173 ISIDDEIYDPNMKRNIYQGNYSDFYQKYIG--------NSKDKHQQN----RKRYNYKDQERLQE 225

  Fly   190 AYNDLKQLDQF----PEGFSSIRSLQLQSNELP---SLPDN--FF---------------AVTHA 230
            |:..:.::...    |:........:|.|.:.|   .||.|  .|               .:.:|
Mosquito   226 AFQSVLRISPLFPMNPKYRKLCHQFKLYSRKDPFRVPLPYNRHIFDEIQVPIYGAYLYDALIIYA 290

  Fly   231 RLET-------------------LNVSCNKLSTLPRYEQNNHAALVNLSLAGNHLNDSIFEPLHN 276
            |..|                   .|.|.:.:.....|...|..|..|.|:.....:|.:...||.
Mosquito   291 RAATEVLRDGGDVSDGRLIMRHIFNRSYHSIQGFDVYIDANGDAEGNFSVIALQKDDKVNNSLHM 355

  Fly   277 AAKLRVLHLAY---NRIG---VLPAACVRNWPELEILVLSGNMLQQLPEEVA------------- 322
            :.: .|...||   |..|   .||.....| |...|:.|.|.  ..|.|.|.
Mosquito   356 SMQ-PVALFAYGARNATGTGTTLPEFRYLN-PNRPIMWLKGR--PPLAEPVCGFYNEKCRPKAKD 416

  Fly   323 ---TLGQL--------------------RVLRCCNNLLLCTPQLAKLAMLKVLDLSHNHLDRVNL 364
               ..|.|                    :.|.|    ||....:..:.::...|..:|:..|.||
Mosquito   417 WRYITGALVVILFMAIFTIILFKHYRYEQTLAC----LLWKVDMKDVILITSPDALYNNELRKNL 477

  Fly   365 LALVPSRNLKYLDLSGNLQLQVDEQQFKVCQSQ---------SQRHWSLVDVSGNNRAALPTTKI 420
            ::     .:||.:    ||:...::..||||..         ::|.::.:.:...|..|:.....
Mosquito   478 VS-----RIKYKE----LQINHFQRGEKVCQQSIMVNSAGDVNKRAYTTIGLYRGNIVAIKYLHK 533

  Fly   421 RQVSAQRNQNKTSGPWTMGFAETPGSGDCRKLSVYQLRAANY-------GGS-DEALYGMFEALE 477
            |.|...||..|                     .:.|:|...:       |.| |.....:..:..
Mosquito   534 RTVDITRNIRK---------------------ELKQMREIRHENLITFVGASIDHGTVSILTSYC 577

  Fly   478 GRGRAAQEMSHLVPDLMKQEQMVKDSAVRDYMKFTLLAAQQQCGS---VRSAALFHLTRTRAPSK 539
            .||.....:|:   :.:|.:.|...|.|.|.:|..:.......||   :||            ||
Mosquito   578 ARGSLVDVLSN---EDLKLDHMFVSSLVSDIVKGLIYLHDSDVGSHGNLRS------------SK 627

  Fly   540 VRPLKSKRYVLRMASTGGLDAYLIRRTSQLRLTK---------PDVI----------QKDQIHSM 585
            :  |...|:|.::|.. ||..:...:....:..|         |:::          ||..::|
Mosquito   628 I--LIDSRWVAQIADF-GLHEFKSCQEEPSKFEKELRRSLWKAPELLRDPNCPPKGTQKGDVYS- 688

  Fly   586 PDPHVLELILSNDDEYLVVGNAQLWSVMDI---DRAAREIRKEENSLL-AAKRLVDIAQSFAAAE 646
                 ..::|     |.::|....|..:::   |..||.:..||..:. .:.|.:|..:
Mosquito   689 -----FGIVL-----YEIIGRKGPWGDLNMSWQDIVARVMSPEEYGIFRPSLRGIDAPE------ 737

  Fly   647 SLSVIVVRFRHLGTDVDHLIRELKQSVRKKPQPVSLPLSSGSVCKRTCCDRSNACRHRAIEQEPL 711
                .|::..|...:.|...|...:.||.|.:|:...|...............|.....|.||
Mosquito   738 ----YVIQLLHSCWEEDPEDRPDIRLVRVKLKPMQAGLKPNIFDNMLAIMEKYAYNLEGIVQE-- 796

  Fly   712 AGRSSPSGQSDRDLLAKDKDDEFVLAHARVLQEEQQLEMLDETESVSESV-----LSEEQFKC-- 769
                     ....|..:.|..|.:|           |.||  .:||:||:     :..|.|.|
Mosquito   797 ---------RTNQLSEEKKKTESLL-----------LRML--PKSVAESLKRGERVEAECFDCVT 839

  Fly   770 --------WEYMLEQNTQLLFDKELNTI---------SKSFTKQRTVPNAIMAATVLPERN---- 813
                    :..:..|:|.....:.||.:         |....|..|:.:|.|..:.||.||
Mosquito   840 IFFSDLVGFTELCAQSTPFEVVEMLNDLYTCCDFIISSYDVYKVETIGDAYMVVSGLPLRNGDRH 904

  Fly   814 -----DFTSNLMRTVTNKFISTSTPQLPQPITTSVPLGSYHQVKQAPPGHFGSALSFQQAHSYGY 873
                 ....:|:.:::|..|.      .:|       |.:.|::...  |.|..:    |...|.
Mosquito   905 AGEIASLALHLLNSISNLEIR------HRP-------GEFIQMRIGI--HSGQCV----AGVVGL 950

  Fly   874 NLFDAKPRPKFHGGTVK-----RSAGP------NSAYFGSLQRLMPYNFEYDFAVTQERERNILD 927
            .:    ||....|.||.     .|.|.      :|..:|.|::|..|..|         ||.|:.
Mosquito   951 KM----PRYCLFGDTVNTASRMESNGEALKIHISSITYGLLKKLGGYKCE---------ERGIIK 1002

  Fly   928 EEEHDDDDFNEHESRMRKYW 947
            .         :.:..||.||
Mosquito  1003 V---------KGKGEMRTYW 1013

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phlpp	NP_001260558.1	leucine-rich repeat	91..110	CDD:275380	5/33 (15%)
		LRR_8	109..169	CDD:290566	14/76 (18%)
		leucine-rich repeat	111..135	CDD:275380	7/33 (21%)
		leucine-rich repeat	136..158	CDD:275380	5/28 (18%)
		leucine-rich repeat	159..183	CDD:275380	3/23 (13%)
		leucine-rich repeat	184..209	CDD:275380	3/28 (11%)
		LRR_8	205..266	CDD:290566	17/99 (17%)
		leucine-rich repeat	210..230	CDD:275380	7/39 (18%)
		leucine-rich repeat	232..255	CDD:275380	5/41 (12%)
		LRR_RI	<256..410	CDD:238064	40/204 (20%)
		leucine-rich repeat	256..276	CDD:275380	4/19 (21%)
		LRR_8	279..359	CDD:290566	23/121 (19%)
		leucine-rich repeat	280..303	CDD:275380	8/28 (29%)
		leucine-rich repeat	304..348	CDD:275380	12/79 (15%)
		leucine-rich repeat	349..372	CDD:275380	5/22 (23%)
		PP2Cc	461..655	CDD:294085	41/227 (18%)
AgaP_AGAP008848	XP_319590.4	Periplasmic_Binding_Protein_Type_1	1..363	CDD:299141	56/332 (17%)
		PK_GC-A_B	506..770	CDD:270944	58/323 (18%)
		STYKc	508..755	CDD:214568	53/306 (17%)
		HNOBA	<795..824	CDD:285003	12/52 (23%)
		CYCc	803..993	CDD:214485	47/225 (21%)
		Guanylate_cyc	830..1016	CDD:278633	46/225 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900