DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Phlpp and AgaP_AGAP009775

DIOPT Version :9

Sequence 1:	NP_001260558.1	Gene:	Phlpp / 35178	FlyBaseID:	FBgn0032749	Length:	954	Species:	Drosophila melanogaster
Sequence 2:	XP_318863.4	Gene:	AgaP_AGAP009775 / 1279182	VectorBaseID:	AGAP009775	Length:	547	Species:	Anopheles gambiae

Alignment Length:	527	Identity:	129/527 - (24%)
Similarity:	198/527 - (37%)	Gaps:	127/527 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 YNYLTQLEVCE----NEMEVLDLS--SLAQLETLKCSRNKLMELIING----TNLQTLVADHNYL 121
            :.|..:||:..    |...|.|.|  .|.:|:|:..|||.:.:|.:..    .||..|....|.|
Mosquito    84 FQYFKKLEILRIIDANVPSVGDRSFWGLVRLKTIDLSRNNITQLAMENFRGQDNLIELDLSRNRL 148

  Fly   122 HNI-STTNTHPVPL----------------------KLQRIDISHNNFSELPNWV-GACASLTAI 162
            .|| |.|..|...|                      ||:.:|:|:|:..:||..| .....|..:
Mosquito   149 DNIASGTFAHLKELKTLHLIDNSITEFNQRLFLHLAKLKHLDLSYNSIDDLPPEVFKDVQDLKIL 213

  Fly   163 NASHNRLNNVAVLLRNYRITELVSLDLAYNDLKQLDQFPEGFSSIRSLQ---LQSNELPSLPDNF 224
            .....||:|:...:.|. ::.|..|||..|.:|.||:  |.|..:|.||   |..|:|..:.|..
Mosquito   214 RVRGCRLSNINPQIYNI-LSHLTELDLGQNQIKFLDK--EEFKDLRHLQTLRLDGNQLSVIIDEL 275

  Fly   225 FAVTHARLETLNVSCNKLSTLPRYEQNNHAALVNLSLAGNHLNDSIFEPLHNAAKLRVLHLAYNR 289
            | :....|..|::|.|:|:.:.                     |..||   |.|.|..|..:||:
Mosquito   276 F-IHQKGLTLLDISRNRLAKIA---------------------DRAFE---NLANLTFLDASYNK 315

  Fly   290 IGVLPAACVRNWPELEILVLSGNMLQQLPEEVATLGQLRVLRCCNNLLLCTPQLAKLAM------ 348
            :..:...|.|....|:.|.:|||:...|.|...|   :.|::....|::.......|.:
Mosquito   316 LSHIEPVCFRPLRNLQTLNISGNIQLDLGEMEDT---INVIKNITGLMVADMGTLPLNLFSPFRH 377

  Fly   349 LKVLDLSHNHLDRVNLLALVPSRNLKYLDLSGNLQLQVDEQQFKVCQSQSQRHWSLVDVSGNNRA 413
            |..|:||.||:|...|..:.|...|::||||.|....:.|                       |.
Mosquito   378 LSALNLSGNHIDNFTLQIIEPLNQLEFLDLSRNQLNGIPE-----------------------RY 419

  Fly   414 ALPTTKIRQVSAQRN--------------QNKTSGPWTMGFAETPGSGDCRKLSVYQLRAANYGG 464
            |....:|..|..:.|              |.|..|   :.:.|.|......:|...::...:..|
Mosquito   420 ATQLARIGDVKLENNPLICDWCHMGPLITQTKKVG---LRWQELPRCFLPERLREVRIDGLHQDG 481

  Fly   465 SDEALYGMFEALEGRGRAAQEMSHLVPDLMKQEQMVKDSAVRDYMKFTLLAAQQQCGSVRSAALF 529
            .::.:    |.:......|...||   :.::|...|...|....:.|.:||.     .|.|.||.
Mosquito   482 VEDCM----EVIVDEDHDAASTSH---NFLEQAGSVSILAACGLIIFIILAI-----IVVSTALC 534

  Fly   530 HLTRTRA 536
             |:|.||
Mosquito   535 -LSRHRA 540

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phlpp	NP_001260558.1	leucine-rich repeat	91..110	CDD:275380	6/22 (27%)
		LRR_8	109..169	CDD:290566	20/83 (24%)
		leucine-rich repeat	111..135	CDD:275380	10/46 (22%)
		leucine-rich repeat	136..158	CDD:275380	7/22 (32%)
		leucine-rich repeat	159..183	CDD:275380	5/23 (22%)
		leucine-rich repeat	184..209	CDD:275380	10/24 (42%)
		LRR_8	205..266	CDD:290566	13/63 (21%)
		leucine-rich repeat	210..230	CDD:275380	7/22 (32%)
		leucine-rich repeat	232..255	CDD:275380	5/22 (23%)
		LRR_RI	<256..410	CDD:238064	38/159 (24%)
		leucine-rich repeat	256..276	CDD:275380	3/19 (16%)
		LRR_8	279..359	CDD:290566	22/85 (26%)
		leucine-rich repeat	280..303	CDD:275380	6/22 (27%)
		leucine-rich repeat	304..348	CDD:275380	11/43 (26%)
		leucine-rich repeat	349..372	CDD:275380	9/22 (41%)
		PP2Cc	461..655	CDD:294085	19/76 (25%)
AgaP_AGAP009775	XP_318863.4	LRR_8	88..148	CDD:290566	17/59 (29%)
		leucine-rich repeat	90..109	CDD:275380	6/18 (33%)
		LRR_RI	114..316	CDD:238064	62/229 (27%)
		leucine-rich repeat	114..137	CDD:275380	6/22 (27%)
		LRR_8	137..196	CDD:290566	16/58 (28%)
		leucine-rich repeat	138..161	CDD:275380	9/22 (41%)
		leucine-rich repeat	162..185	CDD:275380	1/22 (5%)
		leucine-rich repeat	186..233	CDD:275380	12/47 (26%)
		LRR_8	210..268	CDD:290566	20/60 (33%)
		leucine-rich repeat	210..230	CDD:275380	4/19 (21%)
		leucine-rich repeat	234..257	CDD:275380	10/24 (42%)
		LRR_RI	236..>413	CDD:238064	59/206 (29%)
		leucine-rich repeat	258..281	CDD:275380	7/23 (30%)
		LRR_8	280..338	CDD:290566	19/81 (23%)
		leucine-rich repeat	282..305	CDD:275380	9/46 (20%)
		leucine-rich repeat	306..329	CDD:275380	6/22 (27%)
		leucine-rich repeat	330..377	CDD:275380	11/49 (22%)
		TPKR_C2	434..480	CDD:301599	7/48 (15%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910