DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Phlpp and AgaP_AGAP007758

DIOPT Version :9

Sequence 1:	NP_001260558.1	Gene:	Phlpp / 35178	FlyBaseID:	FBgn0032749	Length:	954	Species:	Drosophila melanogaster
Sequence 2:	XP_317759.4	Gene:	AgaP_AGAP007758 / 1278208	VectorBaseID:	AGAP007758	Length:	720	Species:	Anopheles gambiae

Alignment Length:	573	Identity:	124/573 - (21%)
Similarity:	213/573 - (37%)	Gaps:	194/573 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 LKVSASHSGP------------HPLPVEVTAAEEEQAATFGQ----------------------T 46
            |.:|.:|.||            ..|.:|.|.....|..||.|                      |
Mosquito   169 LDLSNNHIGPLNITSLAKLANLQQLGLERTFISNLQHGTFAQQQSLKWLDISYNNLDRFDFDILT 233

  Fly    47 SP---QKLSLKGSQLGGSILIGNYNYLTQ-----LEVCENEMEVLDLS---SLAQLETLKCSRNK 100
            |.   |::.|.|::|...    ||.:|.:     :::..||::.|:..   ..|.|..|..|.|.
Mosquito   234 SSAALQQIFLDGNRLKSL----NYEHLKKTFPALVKIGFNELQELNADCFYGAAVLLDLDLSFNN 294

  Fly   101 LMELIINGTN-----LQTLVADHNYLHNISTTNTHPVPLKLQRIDISHNNFSELPNWVGACASLT 160
            :..:.....|     :|||.|::|.:.|::.::...:.||..|  :::|:.:.|.: :....||.
Mosquito   295 ISSIDRMAFNTLHSFVQTLYAENNRISNVTVSDVTNMQLKTLR--LANNSITSLES-IQLFHSLN 356

  Fly   161 AINASHNRLN--NVA-----VLLRNYRI----------------TELVSLDLAYNDLKQLD---- 198
            .::.|:|.:.  |:.     |.|:..|:                ..|..||::||:|.:.|
Mosquito   357 ELDLSNNYIGPLNITCLTKLVFLKELRLQRTFISNLQHGTFAQQQSLKWLDISYNNLDRFDFDIL 421

  Fly   199 --------------------------QFPEGFS-------------------------------- 205
                                      .||..|.
Mosquito   422 TSSAALQQIFLDGNRLKSLNYEHLKKTFPALFEMSSLEEVPKQLFDTFSNLVLVNFTSSGIKFIN 486

  Fly   206 --------SIRSLQLQSNELPSLPDNFFAVTHARLETLNVSCNKLSTLPRYEQNNHAALVNLSLA 262
                    ::::|.|.||.:..|..|.|:...|.|| ||:|.||:|::.|...|..:.|..|.|.
Mosquito   487 RYSLDRARNLQNLDLSSNAIEQLNANCFSGATALLE-LNLSFNKISSIDRMAFNTLSNLELLRLT 550

  Fly   263 GN---HLNDSIFEPLHNAAKLRVLHLAYNRIGVLPAACVRNWPELEILVLSGNMLQQLPEEVATL 324
            ||   .|::.:|:||.:   |..::|..|.:.|:.|.......:|:.::|..|.:..:.|
Mosquito   551 GNKLRSLDNKVFQPLES---LHTIYLNSNELQVIEAGLFVENSKLKNMLLQNNHISMVEE----- 607

  Fly   325 GQLRVLRCCNNLL-LCTPQLAKLAMLKV----LDLSHNHLDRVNL---LALVPSRN--------- 372
            |.|.:.....::: |...:|.||.:.|:    |.|::|.||.:||   :..|.:.|
Mosquito   608 GALGIFISTESIVSLSNNKLTKLNLEKIKVTHLYLTNNTLDTLNLSPWIGTVYAENNIISNVTVS 672

  Fly   373 ----------LKYLDLSGNLQLQVDEQQFKVCQSQSQRHWSLVDVSGNNRAAL 415
                      ||:||:|.|   .:|...|.:..|.:......:|  ||...:|
Mosquito   673 DHGTFTQQQSLKWLDISYN---NLDRFDFDILTSSAALQQIFLD--GNRLKSL 720

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phlpp	NP_001260558.1	leucine-rich repeat	91..110	CDD:275380	4/18 (22%)
		LRR_8	109..169	CDD:290566	16/64 (25%)
		leucine-rich repeat	111..135	CDD:275380	6/23 (26%)
		leucine-rich repeat	136..158	CDD:275380	3/21 (14%)
		leucine-rich repeat	159..183	CDD:275380	7/46 (15%)
		leucine-rich repeat	184..209	CDD:275380	10/94 (11%)
		LRR_8	205..266	CDD:290566	23/103 (22%)
		leucine-rich repeat	210..230	CDD:275380	7/19 (37%)
		leucine-rich repeat	232..255	CDD:275380	10/22 (45%)
		LRR_RI	<256..410	CDD:238064	44/183 (24%)
		leucine-rich repeat	256..276	CDD:275380	9/22 (41%)
		LRR_8	279..359	CDD:290566	19/84 (23%)
		leucine-rich repeat	280..303	CDD:275380	5/22 (23%)
		leucine-rich repeat	304..348	CDD:275380	10/44 (23%)
		leucine-rich repeat	349..372	CDD:275380	9/29 (31%)
		PP2Cc	461..655	CDD:294085
AgaP_AGAP007758	XP_317759.4	leucine-rich repeat	22..45	CDD:275380
		LRR_8	45..128	CDD:290566
		leucine-rich repeat	46..69	CDD:275380
		leucine-rich repeat	70..93	CDD:275380
		leucine-rich repeat	94..117	CDD:275380
		LRR_RI	110..366	CDD:238064	45/203 (22%)
		LRR_8	116..176	CDD:290566	2/6 (33%)
		leucine-rich repeat	118..141	CDD:275380
		leucine-rich repeat	142..165	CDD:275380
		leucine-rich repeat	166..189	CDD:275380	5/19 (26%)
		LRR_8	189..248	CDD:290566	12/58 (21%)
		leucine-rich repeat	190..213	CDD:275380	7/22 (32%)
		leucine-rich repeat	214..237	CDD:275380	2/22 (9%)
		leucine-rich repeat	238..284	CDD:275380	10/49 (20%)
		leucine-rich repeat	285..306	CDD:275380	5/20 (25%)
		leucine-rich repeat	310..332	CDD:275380	6/21 (29%)
		LRR_RI	<330..413	CDD:238064	18/85 (21%)
		leucine-rich repeat	333..354	CDD:275380	5/23 (22%)
		leucine-rich repeat	355..378	CDD:275380	4/22 (18%)
		LRR_8	379..437	CDD:290566	9/57 (16%)
		leucine-rich repeat	379..402	CDD:275380	2/22 (9%)
		leucine-rich repeat	403..426	CDD:275380	7/22 (32%)
		leucine-rich repeat	427..495	CDD:275380	3/67 (4%)
		leucine-rich repeat	473..493	CDD:275380	0/19 (0%)
		LRR_8	494..554	CDD:290566	23/60 (38%)
		LRR_RI	<495..693	CDD:238064	58/209 (28%)
		leucine-rich repeat	496..519	CDD:275380	7/22 (32%)
		leucine-rich repeat	520..543	CDD:275380	10/23 (43%)
		LRR_8	542..602	CDD:290566	17/62 (27%)
		leucine-rich repeat	544..567	CDD:275380	9/22 (41%)
		leucine-rich repeat	568..591	CDD:275380	5/22 (23%)
		leucine-rich repeat	592..610	CDD:275380	5/22 (23%)
		leucine-rich repeat	630..682	CDD:275380	11/51 (22%)
		leucine-rich repeat	683..706	CDD:275380	9/25 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910