DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Phlpp and AgaP_AGAP006643

DIOPT Version :9

Sequence 1:	NP_001260558.1	Gene:	Phlpp / 35178	FlyBaseID:	FBgn0032749	Length:	954	Species:	Drosophila melanogaster
Sequence 2:	XP_316671.4	Gene:	AgaP_AGAP006643 / 1277226	VectorBaseID:	AGAP006643	Length:	951	Species:	Anopheles gambiae

Alignment Length:	1016	Identity:	202/1016 - (19%)
Similarity:	323/1016 - (31%)	Gaps:	434/1016 - (42%)

- Green bases have known domain annotations that are detailed below.

  Fly    70 LTQLEV-CENEMEVLDLS---------SLAQ---LETLKCSRNKLMEL----IINGTNLQTLVAD 117
            ||:|.| .:..:|:||||         .|||   |..|..|.|.:.:|    :...::|..|:..
Mosquito    49 LTELPVFADFNIEILDLSDNLFTTIPPELAQFPRLHYLDLSANAITQLREDALTGMSSLSILILS 113

  Fly   118 HNYLHNIST-TNTHPVPL-----KLQRIDISHNNFSELPNWVGACASLTAINASHNRLNNVAVLL 176
            .|   |||. .:.||..|     .|:.:.::.|:|:...:
Mosquito   114 EN---NISNWADIHPNQLLLPAGNLKELRLAKNHFTSFSS------------------------- 150

  Fly   177 RNYRITELVSLDLAYNDLKQL-------DQFPEGFSSIRSLQLQSNELPSLPDNFFAVTHARLET 234
             |.:...|.||.|.|.||.:.       .:..:|..|:..|:|..|.:.|:.| ..:.|..|||
Mosquito   151 -NDKSLVLTSLSLRYLDLSECKISKVSGSEVIQGLRSLEHLKLSGNPIISMSD-MQSTTLKRLE- 212

  Fly   235 LNVSCNKLSTLPRYEQNNHAALVNLSLAGNHLNDSIF----EPLHNAAKLRVLHLAYNRIGVLPA 295
            || || |||.||........||..::||.||....:.    .|:.:|: ||.::|::..:..|.
Mosquito   213 LN-SC-KLSALPPTIFTGLTALKEVNLARNHRLSLVLPHEDTPVQSAS-LRKINLSHCNMDTLD- 273

  Fly   296 ACVRNWPELEILVLSGNMLQQLPEEVATLGQLRVLRCCNNLLLCTPQLAKLAMLKVLDLSHNHLD 360
              :..:|.|...::.|||::||..:                     ..:...:|:.||||.|.:.
Mosquito   274 --LHGFPNLMTAIVRGNMVRQLDRD---------------------SFSGTLLLEHLDLSFNSIS 315

  Fly   361 RVNLLALVPSRNLKYLDLSGNLQLQVDEQQFK----VCQSQSQRHW----------SLV------ 405
            .::..|....::||.||||.|:..::|.:.||    :......|::          |||
Mosquito   316 SIHPEAFRTLKHLKTLDLSFNMISRIDGKLFKANDLLTHINLSRNYISRFSRISADSLVYLNMSW 380

  Fly   406 --------------------DVSGNNRAALPTT-----------KIRQVSAQRNQ---------- 429
                                |:|.|..:.:|.|           .:.::|..||.
Mosquito   381 CEILTLDWDALASMGELIELDLSNNLLSDIPDTLSSGTLQTLDLSMCRLSTMRNTTLAGLPELVR 445

  Fly   430 -----NKTSGPWTMGF------------AETPGSGDCRKLSVYQ--------------------- 456
                 |:.:.|:.:.|            .:.|...|||....:|
Mosquito   446 INLSGNRFTTPFRVEFFDKNPFLSEIWLGDNPWRCDCRSDEFFQFFQFLTDPPGRIGDRKNLQCN 510

  Fly   457 ----LRAANYGGSDEALYGMFEALEGRGRAAQEMSHLVPDLMKQEQMVKDSAVRDYMKFTLLAAQ 517
                ...|::.|:..:::..:|.:   |.|.:..:.|         ||...|...:  |.|:::.
Mosquito   511 TPEDFFGASWEGACRSVWYPYETI---GNAERIWTWL---------MVGVLAFFGF--FCLISSI 561

  Fly   518 QQCGSVRSAALFHLTRTRAPSKVRPLKSKRYVLRMASTGGLDAYLIRRTSQLRLTKPDVIQKDQI 582
            ::..|.|........|.:...::|.                    |.|.:::||      |:|..
Mosquito   562 KKFISSRQKLAAEREREQNLQELRE--------------------IARDNRVRL------QQDAP 600

  Fly   583 HSMPDPHVLELILSNDDEYLVVGNAQLWSVMDIDRAAREIRKE--ENSLLAAKRLVDIAQSFAAA 645
            .:.||                               |||.|..  |::||..|  :| |.|||:
Mosquito   601 QNAPD-------------------------------ARESRPPCYEDALLLPK--LD-AASFAS- 630

  Fly   646 ESLSVIVVRFRHLGTDVDHLIRELKQSVRKKPQPVSLPLSSGSVCKRTCCDRSNACRHRAIEQEP 710
                            :|.|:...|:..|::                         ..||...|
Mosquito   631 ----------------LDELMLRGKRRKRRR-------------------------NRRASGTE- 653

  Fly   711 LAGRSSPSGQSDRDLLAKDKDDEFVLAHARVLQEEQQLEMLDETESVSESVLSEEQFKCWEYMLE 775
                            |||.||         ::||::::....|.:.||.|||..
Mosquito   654 ----------------AKDDDD---------IEEEERIQSRQRTRTRSEDVLSRR---------- 683

  Fly   776 QNTQLLFDKELNTISKSFTKQRTVPNAIMAATVLPERND----FTSNLMRTVTNKFISTSTPQL- 835
                  ||..                        ||.:|    ..|...|..:|:.:|.:..|:
Mosquito   684 ------FDDS------------------------PEPSDERPPVRSIYERPTSNRVVSLTEAQIH 718

  Fly   836 -PQPITTSVP------------------LGSYHQVKQA-----------PPGHFGS--ALSFQQA 868
             ..|.||:.|                  |...||...|           ||....|  ||...|.
Mosquito   719 TTSPATTASPEQRDREEDEEMHYHSIDILSLNHQPSTASDRSRTGAAPPPPPRLSSTVALPSDQI 783

  Fly   869 HSY-GYNLFDAKPRPKFHGGTVKRSAGPNSAYFGSLQRLMP 908
            ..: |.:          |....||...|       ||.|.|
Mosquito   784 EQFTGIS----------HSPYAKRKVKP-------LQHLNP 807

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phlpp	NP_001260558.1	leucine-rich repeat	91..110	CDD:275380	5/22 (23%)
		LRR_8	109..169	CDD:290566	12/65 (18%)
		leucine-rich repeat	111..135	CDD:275380	9/29 (31%)
		leucine-rich repeat	136..158	CDD:275380	3/21 (14%)
		leucine-rich repeat	159..183	CDD:275380	1/23 (4%)
		leucine-rich repeat	184..209	CDD:275380	9/31 (29%)
		LRR_8	205..266	CDD:290566	24/60 (40%)
		leucine-rich repeat	210..230	CDD:275380	6/19 (32%)
		leucine-rich repeat	232..255	CDD:275380	11/22 (50%)
		LRR_RI	<256..410	CDD:238064	41/197 (21%)
		leucine-rich repeat	256..276	CDD:275380	6/23 (26%)
		LRR_8	279..359	CDD:290566	17/79 (22%)
		leucine-rich repeat	280..303	CDD:275380	4/22 (18%)
		leucine-rich repeat	304..348	CDD:275380	6/43 (14%)
		leucine-rich repeat	349..372	CDD:275380	7/22 (32%)
		PP2Cc	461..655	CDD:294085	35/195 (18%)
AgaP_AGAP006643	XP_316671.4	LRRNT	27..>54	CDD:214470	3/4 (75%)
		LRR_8	59..117	CDD:290566	16/60 (27%)
		LRR_RI	61..387	CDD:238064	93/383 (24%)
		leucine-rich repeat	61..82	CDD:275380	8/20 (40%)
		leucine-rich repeat	83..106	CDD:275380	5/22 (23%)
		leucine-rich repeat	107..134	CDD:275380	9/29 (31%)
		LRR_8	134..197	CDD:290566	16/88 (18%)
		leucine-rich repeat	135..161	CDD:275380	6/51 (12%)
		leucine-rich repeat	162..186	CDD:275380	5/23 (22%)
		leucine-rich repeat	187..231	CDD:275380	18/47 (38%)
		LRR_8	206..269	CDD:290566	24/66 (36%)
		leucine-rich repeat	232..258	CDD:275380	6/25 (24%)
		LRR_8	258..314	CDD:290566	17/80 (21%)
		leucine-rich repeat	259..303	CDD:275380	11/67 (16%)
		LRR_RI	<304..478	CDD:238064	32/173 (18%)
		LRR_8	304..362	CDD:290566	18/57 (32%)
		leucine-rich repeat	304..327	CDD:275380	7/22 (32%)
		leucine-rich repeat	328..347	CDD:275380	8/18 (44%)
		leucine-rich repeat	352..396	CDD:275380	4/43 (9%)
		leucine-rich repeat	397..418	CDD:275380	5/20 (25%)
		LRR_8	399..453	CDD:290566	9/53 (17%)
		leucine-rich repeat	419..440	CDD:275380	3/20 (15%)
		TPKR_C2	476..>515	CDD:301599	5/38 (13%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910