DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Phlpp and AgaP_AGAP006183

DIOPT Version :9

Sequence 1:	NP_001260558.1	Gene:	Phlpp / 35178	FlyBaseID:	FBgn0032749	Length:	954	Species:	Drosophila melanogaster
Sequence 2:	XP_316248.3	Gene:	AgaP_AGAP006183 / 1276849	VectorBaseID:	AGAP006183	Length:	503	Species:	Anopheles gambiae

Alignment Length:	474	Identity:	113/474 - (23%)
Similarity:	182/474 - (38%)	Gaps:	127/474 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 ATFGQTSPQKLSLKGSQLGGSILIGNYNYLTQLEVCENEMEVLDLSSLAQLE---TLKCSRNKLM 102
            ||..:||.       |.||..        ||||:|.:|::..:..|:|..|.   .|..:.|::.
Mosquito   114 ATIEETSL-------SSLGRG--------LTQLDVSQNQLMSVPSSALKNLHYLLILNLNHNRIS 163

  Fly   103 EL---IINGTN-LQTLVADHNYLHNISTTNTHPVPLKLQRIDISHNNFSELPNWVGACASLTAIN 163
            ::   ...|.: |:.|....|.|..|.......:..||:|:::..|:.:.:|
Mosquito   164 QIHNRAFEGLDTLEILTIYENKLTFIEPDAFRGLDKKLKRLNLGGNDLTAVP------------- 215

  Fly   164 ASHNRLNNVAVLLRNYRITELVSLDLAYNDLKQLDQFP-EGFSSIRSLQLQSNELPSLPDN-FFA 226
                  .....:|.|.|     .|:|..|.:|.:.:.. ||..::.||.|..|:|..:|.. ||.
Mosquito   216 ------QKALSMLDNLR-----KLELQENRIKTIKEGDFEGLENLDSLILAHNQLTEVPARVFFH 269

  Fly   227 VTHARLETLNVSCNKLSTLPR-----YEQNNHAALVNLSLAGNHLN---DSIFEPLHNAAKLRV- 282
            :|  .|.:|.:..|.:|.:.:     .|:|    |..|.|..|:|:   .....|||....|.:
Mosquito   270 LT--LLNSLELEGNSISYIAKEAFEGLEEN----LQYLRLGDNNLHIIPSEALRPLHRLRHLDLR 328

  Fly   283 ---------------------LHLAYNRIGVLPAACVRNWPELEILVLSGNMLQQLPEEV--ATL 324
                                 |:|..|.|.||||....|...||.|.:..|.|.::||||  ..:
Mosquito   329 SNNISVISEDAFVGFGDSITFLNLQKNDIKVLPALVFENLNSLETLSIQNNKLTRIPEEVMEPIM 393

  Fly   325 GQLRVLRCCNNLLLCTPQLAKLAMLKVLDLSHNHLDRVNLLALVPSRNLKYLDLSGNLQLQVDEQ 389
            ..|||:...:|.|:|:.:|....               |||     |:||      |...::.::
Mosquito   394 DSLRVVDIMDNPLICSCELVWFP---------------NLL-----RDLK------NRDDEMTQK 432

  Fly   390 QFKVCQSQSQRHWSLVDVSGNNRAALPTTKIRQVSAQRNQNKTSGPWTMGFAETPGSGDCRKLSV 454
            :..:|..|::.....|.       .:|..::..|..:.:.:..||..:.|   .||:   ..||.
Mosquito   433 KRPMCTMQNEHREYYVQ-------NMPLERMSCVGKKYHTSSLSGNGSTG---RPGA---TLLST 484

  Fly   455 YQLRAANYGGSDEALYGMF 473
              :.||...||....||.|
Mosquito   485 --VLAALVTGSTVIGYGRF 501

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phlpp	NP_001260558.1	leucine-rich repeat	91..110	CDD:275380	4/24 (17%)
		LRR_8	109..169	CDD:290566	10/60 (17%)
		leucine-rich repeat	111..135	CDD:275380	5/23 (22%)
		leucine-rich repeat	136..158	CDD:275380	4/21 (19%)
		leucine-rich repeat	159..183	CDD:275380	3/23 (13%)
		leucine-rich repeat	184..209	CDD:275380	6/25 (24%)
		LRR_8	205..266	CDD:290566	19/66 (29%)
		leucine-rich repeat	210..230	CDD:275380	8/20 (40%)
		leucine-rich repeat	232..255	CDD:275380	6/27 (22%)
		LRR_RI	<256..410	CDD:238064	44/180 (24%)
		leucine-rich repeat	256..276	CDD:275380	7/22 (32%)
		LRR_8	279..359	CDD:290566	26/103 (25%)
		leucine-rich repeat	280..303	CDD:275380	10/44 (23%)
		leucine-rich repeat	304..348	CDD:275380	16/45 (36%)
		leucine-rich repeat	349..372	CDD:275380	3/22 (14%)
		PP2Cc	461..655	CDD:294085	5/13 (38%)
AgaP_AGAP006183	XP_316248.3	leucine-rich repeat	82..102	CDD:275380
		leucine-rich repeat	104..127	CDD:275380	7/19 (37%)
		LRR_RI	<126..244	CDD:238064	29/149 (19%)
		leucine-rich repeat	128..151	CDD:275380	9/22 (41%)
		leucine-rich repeat	152..175	CDD:275380	3/22 (14%)
		LRR_8	154..211	CDD:290566	12/56 (21%)
		leucine-rich repeat	176..200	CDD:275380	5/23 (22%)
		LRR_RI	<200..392	CDD:238064	56/221 (25%)
		leucine-rich repeat	201..224	CDD:275380	5/41 (12%)
		LRR_8	224..283	CDD:290566	20/65 (31%)
		leucine-rich repeat	225..248	CDD:275380	7/27 (26%)
		leucine-rich repeat	249..272	CDD:275380	9/24 (38%)
		LRR_8	273..332	CDD:290566	15/62 (24%)
		leucine-rich repeat	273..297	CDD:275380	5/23 (22%)
		leucine-rich repeat	298..321	CDD:275380	7/22 (32%)
		leucine-rich repeat	322..346	CDD:275380	1/23 (4%)
		leucine-rich repeat	347..370	CDD:275380	9/22 (41%)
		LRR_8	350..406	CDD:290566	22/55 (40%)
		TPKR_C2	404..458	CDD:301599	15/86 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910