Protein Alignment Phlpp and AgaP_AGAP008691

DIOPT Version :9

• Sequence 1: NP_001260558.1
• Gene: Phlpp / 35178
• FlyBaseID: FBgn0032749
• Length: 954
• Species: Drosophila melanogaster
• Sequence 2: XP_314790.4
• Gene: AgaP_AGAP008691 / 1275535
• VectorBaseID: AGAP008691
• Length: 1037
• Species: Anopheles gambiae
• Alignment Length: 516
• Identity: 95/516 - (18%)
• Similarity: 160/516 - (31%)
• Gaps: 216/516 - (41%)

  Fly   306 ILVLSGNMLQQLPEEV-ATLGQLRVLRCCNNLLLCTPQLAKLAMLKVL-------------DLSH 356
            :.:.|||  .|||.:: .|:|..:..|..         :.|:|..||.             |:||
Mosquito   528 VSIASGN--SQLPAQLFTTIGIYKGERVA---------IKKVAKKKVYITSTLLWEIKQARDVSH 581

  Fly   357 NH----------LDRVNLLALV---PSRNLKYLDLSGNLQLQVDEQQFK------VCQSQSQRHW 402
            .:          |.|..:|.|.   |..:||  |:..|..:|:| ..|:      |.:..:..|.
Mosquito   582 ENTVRFVGACIDLPRPTILILTEYCPKGSLK--DVLENEAIQLD-WNFRMSLIHDVVKGMAYLHN 643

  Fly   403 SLVDVSGNNRAA---------------------------LPTTKIRQVSAQRNQNKTS------- 433
            |.|.|.|..|:.                           ||.|.|....|.:..:..|
Mosquito   644 SDVGVHGKLRSCNCLIDGRFVLKISDFGLRTLTTPSEYLLPATVIPGTPATQKGDVYSFAIILEE 708

  Fly   434 -----GPW--------------TMGFAETP------GSGDCRK--LSVYQ--------------- 456
                 ||:              .:...|:|      |..||..  |.:.:
Mosquito   709 IVVRGGPYETARQFLDPQAIVERVALHESPPFRPFVGQRDCPPDLLDLMEKCWSDSPDDRPTFSG 773

  Fly   457 ----LRAANYGGSDEALYGMFEALEGRGRAAQEMSHLVPDLMKQEQMVKDSAVRDYMKFTLL--- 514
                :|....|..:..:..:...:|   :.|..:..||.:  |.||:..:....:.:.:.:|
Mosquito   774 IRSSVRLIMKGFCENLMDDLLRRME---QYANNLESLVEE--KTEQLSMEKRRTEELLYQVLPRP 833

  Fly   515 AAQQ------------QCGSVRSAALFHLTRTRAPSKVRPLKSKRYVLRMASTGGLDAYLIRRTS 567
            .|||            :|.::..:.:...|...|.|  ||::...::..:.||
Mosquito   834 VAQQLLAGEMVQPEQFECVTIYFSDIVGFTALCAQS--RPMEVVDFLNDLYST------------ 884

  Fly   568 QLRLTKPDVIQKDQIHSMPDPHVLELILSNDDEYLVVGNAQLWSVMDIDRAAREIRKEENSLLAA 632
                       .|:|....|.:.:|.|   .|.|:||......:..|   .||||.      |.|
Mosquito   885 -----------FDRIIGFYDVYKVETI---GDAYMVVSGLPERNGHD---HAREIG------LMA 926

  Fly   633 KRLVDIAQSFAAAESLSVIVVRFRHLGTDVDHLIRELKQSVRKKPQ---PVSLPLSSGSVC 690
            ..::|..:||                             :::.||:   .:.:.:.||.||
Mosquito   927 LAILDAVRSF-----------------------------TIKHKPEYQLKIRIGIHSGPVC 958

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Phlpp	NP_001260558.1	leucine-rich repeat	91..110	CDD:275380
		LRR_8	109..169	CDD:290566
		leucine-rich repeat	111..135	CDD:275380
		leucine-rich repeat	136..158	CDD:275380
		leucine-rich repeat	159..183	CDD:275380
		leucine-rich repeat	184..209	CDD:275380
		LRR_8	205..266	CDD:290566
		leucine-rich repeat	210..230	CDD:275380
		leucine-rich repeat	232..255	CDD:275380
		LRR_RI	<256..410	CDD:238064	33/136 (24%)
		leucine-rich repeat	256..276	CDD:275380
		LRR_8	279..359	CDD:290566	16/76 (21%)
		leucine-rich repeat	280..303	CDD:275380
		leucine-rich repeat	304..348	CDD:275380	10/42 (24%)
		leucine-rich repeat	349..372	CDD:275380	10/48 (21%)
		PP2Cc	461..655	CDD:294085	39/208 (19%)
AgaP_AGAP008691	XP_314790.4	Periplasmic_Binding_Protein_Type_1	3..410	CDD:299141
		ANF_receptor	20..392	CDD:279440
		PKc_like	527..784	CDD:304357	50/269 (19%)
		HNOBA	<780..838	CDD:285003	11/62 (18%)
		CYCc	817..1008	CDD:214485	37/208 (18%)
		Guanylate_cyc	844..1029	CDD:278633	33/181 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900