DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Phlpp and AgaP_AGAP008611

DIOPT Version :9

Sequence 1:	NP_001260558.1	Gene:	Phlpp / 35178	FlyBaseID:	FBgn0032749	Length:	954	Species:	Drosophila melanogaster
Sequence 2:	XP_314705.4	Gene:	AgaP_AGAP008611 / 1275458	VectorBaseID:	AGAP008611	Length:	887	Species:	Anopheles gambiae

Alignment Length:	633	Identity:	139/633 - (21%)
Similarity:	232/633 - (36%)	Gaps:	190/633 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    94 LKCSRNKLMELIINGTNLQTLVADHNYLHNISTTN---THPVPLKLQRID---ISHNNFSELPNW 152
            |.||          .|:|:.:  :..||..:::..   ...||::....|   :.:.|:.|:..|
Mosquito     1 LSCS----------DTSLRAV--NEEYLRPVNSYKGILLERVPVQSPASDQLALKNENYLEMVRW 53

  Fly   153 VGA-----------------CASLTAINASHNRLNNVAVLLRNY--RITELVSLDLAYNDLKQL- 197
            ..:                 .::|..::.|.|.|   :.|.|:|  |:..|..|.|:.|.|..|
Mosquito    54 RDSNVTDQQFALTFARDGRKFSNLMILDLSANLL---STLRRDYFSRLERLKLLQLSANQLHNLP 115

  Fly   198 -DQFPEGFSSIRSLQLQSNELPSLPDNFFAVTHARLETLNVSCNKLSTLPRYEQNNHAALVNLSL 261
             |.|.: ..::..|.|..|.|..||.:.|... .||..||::.||:..|||   |:.|.|.||:
Mosquito   116 SDIFTD-LPNLVELDLHGNRLGELPLHLFRPL-GRLRVLNLANNKIHDLPR---NSFAGLGNLT- 174

  Fly   262 AGNHLNDSIFEPLHNAAKLRVLHLAYNRIGVLPAACVRNWPELEILVLSGNMLQQLPEEVATLG- 325
                                .||||:||:.|:|....:....||:|.||.|||....:....|.
Mosquito   175 --------------------ELHLAHNRLYVVPFQVFKELRALEVLDLSSNMLVSFLDNFFLLNK 219

  Fly   326 QLRVLRCCNNLL--LCTPQLAKLAMLKVLDLSHNHL---DR---------------VNLLALVPS 370
            ||||||...|::  :....|..|..|:.||||.|.|   ||               .|.:.::||
Mosquito   220 QLRVLRLNGNIIEKISKNALYGLRRLQSLDLSGNKLVFIDRNAFDTLDELRYLNVIQNQIYILPS 284

  Fly   371 ------RNLKYLDLSGNLQLQVDEQQFKVCQSQSQRHWSLVD-------VSGNNR---------- 412
                  |:|:.||||.||...:....|....:..:.|....:       |:.||.
Mosquito   285 TVFSALRSLRSLDLSNNLMRSLPNSIFASQHALVRLHLDATNLETLSNWVARNNHTVNKEVLRSL 349

  Fly   413 ---AALPTTKIRQVS-------------AQRNQNKTSGPWTMGFAETPGSGDCRKLSVYQLRAAN 461
               :....|:::::.             ...|...||.|..:|                :||...
Mosquito   350 RYLSIRNNTRLKEIEPCVFRNVPHLETLLLSNNRLTSLPKEIG----------------ELRRLR 398

  Fly   462 Y--GGSDEALYGMFEALEGRGRAAQEMSHLVPDLMKQEQMVKDSAVRDYMKFTLLAAQQQCGSVR 524
            |  .||::.:|                   :|:.::....::      |..|  |.....|....
Mosquito   399 YLDVGSNDIMY-------------------IPEQIRTLHELQ------YANF--LDNDYGCDCHM 436

  Fly   525 SAALFHLTRTRAPSKVRPLKSKRYVLRMASTGGLDAYLIRRTSQLRLTKPDVIQ--KDQIHSMPD 587
            ...|..|...:|.:..:.:.....:..:....|....::|....:...||:::|  :.::|.:..
Mosquito   437 YWILSWLDELQAENNTQKIYDLLRLSELKCRNGYPGDIVRVLQHISCFKPELLQSSESRMHLLKS 501

  Fly   588 PHVLELILSNDDEYLVVGNAQ---LWSV--MDIDRAAREIRKEENSLL 630
            ..|||.:.:        ||..   :|..  .:|.|.::|  :::.|||
Mosquito   502 DAVLECVFT--------GNPPPDIIWITPKNEILRHSQE--QDQKSLL 539

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phlpp	NP_001260558.1	leucine-rich repeat	91..110	CDD:275380	3/15 (20%)
		LRR_8	109..169	CDD:290566	13/82 (16%)
		leucine-rich repeat	111..135	CDD:275380	5/26 (19%)
		leucine-rich repeat	136..158	CDD:275380	4/41 (10%)
		leucine-rich repeat	159..183	CDD:275380	8/25 (32%)
		leucine-rich repeat	184..209	CDD:275380	8/26 (31%)
		LRR_8	205..266	CDD:290566	21/60 (35%)
		leucine-rich repeat	210..230	CDD:275380	7/19 (37%)
		leucine-rich repeat	232..255	CDD:275380	9/22 (41%)
		LRR_RI	<256..410	CDD:238064	52/187 (28%)
		leucine-rich repeat	256..276	CDD:275380	3/19 (16%)
		LRR_8	279..359	CDD:290566	32/82 (39%)
		leucine-rich repeat	280..303	CDD:275380	8/22 (36%)
		leucine-rich repeat	304..348	CDD:275380	18/46 (39%)
		leucine-rich repeat	349..372	CDD:275380	12/46 (26%)
		PP2Cc	461..655	CDD:294085	30/179 (17%)
AgaP_AGAP008611	XP_314705.4	LRR_RI	72..362	CDD:238064	89/318 (28%)
		LRR_8	75..135	CDD:290566	19/63 (30%)
		leucine-rich repeat	77..100	CDD:275380	8/25 (32%)
		leucine-rich repeat	101..124	CDD:275380	8/23 (35%)
		LRR_8	123..183	CDD:290566	26/84 (31%)
		leucine-rich repeat	125..148	CDD:275380	7/23 (30%)
		leucine-rich repeat	149..172	CDD:275380	11/25 (44%)
		LRR_8	172..255	CDD:290566	34/103 (33%)
		leucine-rich repeat	173..196	CDD:275380	9/43 (21%)
		leucine-rich repeat	197..220	CDD:275380	9/22 (41%)
		leucine-rich repeat	221..244	CDD:275380	8/22 (36%)
		LRR_8	243..303	CDD:290566	19/59 (32%)
		leucine-rich repeat	245..268	CDD:275380	9/22 (41%)
		leucine-rich repeat	269..292	CDD:275380	3/22 (14%)
		leucine-rich repeat	293..316	CDD:275380	8/22 (36%)
		LRR_8	347..407	CDD:290566	11/75 (15%)
		leucine-rich repeat	349..373	CDD:275380	1/23 (4%)
		LRR_4	372..412	CDD:289563	11/74 (15%)
		leucine-rich repeat	397..419	CDD:275380	5/40 (13%)
		I-set	501..614	CDD:254352	12/49 (24%)
		Ig	<576..608	CDD:299845
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910