DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Phlpp and AgaP_AGAP008593

DIOPT Version :9

Sequence 1:	NP_001260558.1	Gene:	Phlpp / 35178	FlyBaseID:	FBgn0032749	Length:	954	Species:	Drosophila melanogaster
Sequence 2:	XP_314696.4	Gene:	AgaP_AGAP008593 / 1275449	VectorBaseID:	AGAP008593	Length:	604	Species:	Anopheles gambiae

Alignment Length:	491	Identity:	130/491 - (26%)
Similarity:	202/491 - (41%)	Gaps:	115/491 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 VEVTAAEEEQAATFGQTSPQKLSLKGS-----QLGGSILIGNYNYLTQLEVCE---NEMEVLDLS 86
            |.:||...|......:.|...|.::.:     :|..:|.| .:..|..||:|:   |.::...|:
Mosquito    40 VSLTACYVEDLRNIREHSQNPLVIQINHCYLQELPNAIFI-RFTDLKVLEICDSRVNNLQDFALN 103

  Fly    87 SLAQLETLKCSRNKLM--------ELIINGTNLQTLVADHNYLHNISTTNTHPVPLKLQRIDISH 143
            .|..:|:|..|||.|.        :|   || ||.|....|.:.:|...:....| .|.::.::.
Mosquito   104 GLRNIESLNLSRNNLTTIKSWSDHDL---GT-LQVLDLRRNLIRSIDELSFQRYP-GLVKLSLAV 163

  Fly   144 NNFSELPNWV-GACASLTAINASHNRLNNVAV-LLRNYRITELVSLDLAYNDLKQLDQFP-EGFS 205
            |..:.:|:.. ...|:|..:|...|.|..:.. .||.  :.:|..:...:|.::.:..|. .|..
Mosquito   164 NFITTVPDGTFKPVANLKNLNLGKNLLTTIEEGTLRG--LNKLTHVAFHHNRIRTIHPFAFVGNG 226

  Fly   206 SIRSLQLQSNELPSLPDNFFAVTHARLETLNVSCNKLSTLPRYEQNNHAALVNLSLAGNHLNDSI 270
            .::.||||.|:|.|...:.|. ...||..||||.|:|.|:.           |||
Mosquito   227 HLKVLQLQGNQLGSFEPDLFG-NLPRLTFLNVSSNELETVG-----------NLS---------- 269

  Fly   271 FEPLHNAAKLRVLHLAYNRIGVLPAACVRNWPELEILVLSGNMLQQLPEEVATLGQLRVLRCCNN 335
               ..|:..||||.|:|||||:|.....:...:||.|.:|.|.|       ||:.:. ||:.|.|
Mosquito   270 ---FKNSGDLRVLDLSYNRIGLLEDNSFKGLYDLEALNVSHNQL-------ATVSKY-VLKDCAN 323

  Fly   336 LLLCTPQLAKLAMLKVLDLSHNHLDRVNLLALVPSRNLKYLDLSGNLQLQVDEQQFKVCQSQSQR 400
                         |:.||||.|.||.|.|.....:..|..|:||.|   .:.|.:..|.:...:.
Mosquito   324 -------------LRDLDLSGNRLDYVGLKLSSATPRLVRLNLSRN---AIGEIERDVFEDLPKL 372

  Fly   401 H---------------WSLVDVSGNNRAALPTTKIRQVSAQRNQNKT-----SGPWTMGFAETPG 445
            |               |||:::|..|   :.....|:::|...::.|     ..||
Mosquito   373 HTLDLAHNQLTDDAFLWSLMNLSVLN---MSQNGFRKINASLLESLTLAELYDNPW--------- 425

  Fly   446 SGDCRKLSVYQLRAANYGGSDEALYGMFEALEGRGR 481
              |||.| |.:|  |::  |...:||....:|..||
Mosquito   426 --DCRFL-VQEL--AHH--SSSVIYGKNYLVEDTGR 454

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phlpp	NP_001260558.1	leucine-rich repeat	91..110	CDD:275380	8/26 (31%)
		LRR_8	109..169	CDD:290566	14/60 (23%)
		leucine-rich repeat	111..135	CDD:275380	6/23 (26%)
		leucine-rich repeat	136..158	CDD:275380	3/22 (14%)
		leucine-rich repeat	159..183	CDD:275380	6/24 (25%)
		leucine-rich repeat	184..209	CDD:275380	4/25 (16%)
		LRR_8	205..266	CDD:290566	20/60 (33%)
		leucine-rich repeat	210..230	CDD:275380	8/19 (42%)
		leucine-rich repeat	232..255	CDD:275380	8/22 (36%)
		LRR_RI	<256..410	CDD:238064	49/168 (29%)
		leucine-rich repeat	256..276	CDD:275380	3/19 (16%)
		LRR_8	279..359	CDD:290566	29/79 (37%)
		leucine-rich repeat	280..303	CDD:275380	11/22 (50%)
		leucine-rich repeat	304..348	CDD:275380	12/43 (28%)
		leucine-rich repeat	349..372	CDD:275380	10/22 (45%)
		PP2Cc	461..655	CDD:294085	6/21 (29%)
AgaP_AGAP008593	XP_314696.4	LRR_8	84..142	CDD:290566	20/61 (33%)
		leucine-rich repeat	84..107	CDD:275380	7/22 (32%)
		LRR_4	107..149	CDD:289563	14/45 (31%)
		leucine-rich repeat	109..131	CDD:275380	7/24 (29%)
		leucine-rich repeat	132..155	CDD:275380	6/23 (26%)
		leucine-rich repeat	156..179	CDD:275380	3/22 (14%)
		LRR_8	179..238	CDD:290566	15/60 (25%)
		leucine-rich repeat	180..203	CDD:275380	6/24 (25%)
		leucine-rich repeat	204..227	CDD:275380	4/22 (18%)
		LRR_RI	227..>424	CDD:238064	70/248 (28%)
		LRR_8	227..286	CDD:290566	28/83 (34%)
		leucine-rich repeat	228..251	CDD:275380	8/23 (35%)
		leucine-rich repeat	252..275	CDD:275380	12/46 (26%)
		LRR_8	276..334	CDD:290566	29/78 (37%)
		leucine-rich repeat	276..299	CDD:275380	11/22 (50%)
		leucine-rich repeat	300..323	CDD:275380	11/30 (37%)
		LRR_8	323..382	CDD:290566	19/74 (26%)
		leucine-rich repeat	324..347	CDD:275380	10/22 (45%)
		leucine-rich repeat	348..369	CDD:275380	7/23 (30%)
		leucine-rich repeat	372..393	CDD:275380	4/20 (20%)
		leucine-rich repeat	394..415	CDD:275380	4/23 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910