DRSC/TRiP Functional Genomics Resources

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Protein Alignment Phlpp and LRRC39

DIOPT Version :9

Sequence 1:NP_001260558.1 Gene:Phlpp / 35178 FlyBaseID:FBgn0032749 Length:954 Species:Drosophila melanogaster
Sequence 2:NP_001243314.1 Gene:LRRC39 / 127495 HGNCID:28228 Length:339 Species:Homo sapiens


Alignment Length:252 Identity:71/252 - (28%)
Similarity:113/252 - (44%) Gaps:39/252 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly   180 RITELVSLDLAYNDLKQLDQFPEGFSSIRSLQLQSNELPSLPDNFFAVTHARLETLNVSCNKLST 244
            ::.:|....|....|.::.:|...|.::..|.|..|.:..:|.....:|  ||:.|.:|.||:.|
Human    81 KLNQLQEWQLHRTGLLKIPEFIGRFQNLIVLDLSRNTISEIPPGIGLLT--RLQELILSYNKIKT 143

  Fly   245 LPRYEQNNHAALVNLSLAGNHLNDSIFEPLHNAAKLRVLHLAYNRIGVLPAACVRNWPELEILVL 309
            :|: |.:|.|:|..|.||.|.....:.:.|.|..||..|.|:.|....:|.| |.|.|.||.|.:
Human   144 VPK-ELSNCASLEKLELAVNRDICDLPQELSNLLKLTHLDLSMNDFTTIPLA-VLNMPALEWLDM 206

  Fly   310 SGNMLQQLPEEVATLGQLRVLRCCNNLLLCTPQ-LAKLAMLKVLDLSHNHLDRVNLLALVPSRNL 373
            ..|.|:|||:.:..:..|..|....|.:.|.|| ::.:..|..|.||:|.|..:. :.:....||
Human   207 GSNKLEQLPDTIERMQNLHTLWLQRNEITCLPQTISNMKNLGTLVLSNNKLQDIP-VCMEEMANL 270

  Fly   374 KYLDLSGN-LQLQV--------DEQ------------------------QFKVCQSQ 397
            ::::...| |:|:|        ||:                        ||.||..|
Human   271 RFVNFRDNPLKLKVSLPPSEGTDEEEERELFGLQFMHTYIQESRRRAALQFCVCHGQ 327

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PhlppNP_001260558.1 leucine-rich repeat 91..110 CDD:275380
LRR_8 109..169 CDD:290566
leucine-rich repeat 111..135 CDD:275380
leucine-rich repeat 136..158 CDD:275380
leucine-rich repeat 159..183 CDD:275380 0/2 (0%)
leucine-rich repeat 184..209 CDD:275380 5/24 (21%)
LRR_8 205..266 CDD:290566 21/60 (35%)
leucine-rich repeat 210..230 CDD:275380 5/19 (26%)
leucine-rich repeat 232..255 CDD:275380 9/22 (41%)
LRR_RI <256..410 CDD:238064 50/176 (28%)
leucine-rich repeat 256..276 CDD:275380 6/19 (32%)
LRR_8 279..359 CDD:290566 29/80 (36%)
leucine-rich repeat 280..303 CDD:275380 8/22 (36%)
leucine-rich repeat 304..348 CDD:275380 14/44 (32%)
leucine-rich repeat 349..372 CDD:275380 6/22 (27%)
PP2Cc 461..655 CDD:294085
LRRC39NP_001243314.1 LRR_RI 79..>263 CDD:238064 58/186 (31%)
LRR_8 84..141 CDD:290566 15/58 (26%)
LRR 1 84..105 4/20 (20%)
leucine-rich repeat 85..107 CDD:275380 5/21 (24%)
LRR 2 107..128 4/20 (20%)
leucine-rich repeat 108..127 CDD:275380 4/18 (22%)
LRR_8 129..188 CDD:290566 24/61 (39%)
LRR 3 130..151 9/21 (43%)
leucine-rich repeat 131..153 CDD:275380 9/22 (41%)
LRR 4 153..176 7/22 (32%)
leucine-rich repeat 154..177 CDD:275380 7/22 (32%)
LRR 5 177..197 8/20 (40%)
leucine-rich repeat 178..200 CDD:275380 8/22 (36%)
LRR 6 200..221 8/20 (40%)
leucine-rich repeat 201..223 CDD:275380 8/21 (38%)
LRR_8 223..280 CDD:290566 15/57 (26%)
LRR 7 223..244 6/20 (30%)
leucine-rich repeat 224..246 CDD:275380 6/21 (29%)
LRR 8 246..267 6/21 (29%)
leucine-rich repeat 247..269 CDD:275380 6/22 (27%)
LRR 9 269..290 6/20 (30%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR45752
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
11.100

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