DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Phlpp and AgaP_AGAP004564

DIOPT Version :9

Sequence 1:	NP_001260558.1	Gene:	Phlpp / 35178	FlyBaseID:	FBgn0032749	Length:	954	Species:	Drosophila melanogaster
Sequence 2:	XP_313866.5	Gene:	AgaP_AGAP004564 / 1274705	VectorBaseID:	AGAP004564	Length:	649	Species:	Anopheles gambiae

Alignment Length:	303	Identity:	62/303 - (20%)
Similarity:	108/303 - (35%)	Gaps:	95/303 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   325 GQLRVLRCCNNLL-LCTPQLAKLAMLKVLDLSHNHLDRVNLLALVPSRNLKYLDLSGNLQLQVDE 388
            |::|.::..|:|: ||:|.:..|..|:.:.|..|.|:...|     ||.:.:...|...:|.:
Mosquito   356 GEMRYIKDINSLVFLCSPLINNLEELREMGLYLNDLNPHGL-----SREMVFSGFSHYSRLDL-- 413

  Fly   389 QQFKVCQSQSQR----HWSLVDVSGNNR-------AALPTTKIRQVSAQRNQNKTSGPW---TMG 439
                :|:.:.||    ..||.......|       :.:|.:...::...:|.::|...:   |:.
Mosquito   414 ----MCEREEQRAEELETSLALADSWKRQGDELLYSMIPRSIAERLREGQNPHETCQSFEEVTVL 474

  Fly   440 FA---ETPGSGDCRKLSVYQLRAAN--YGGSDEALYG-MFEALEGRGRA--------------AQ 484
            ||   ||....|..|.::..:...|  :...||.::. |...:|..|:.              ||
Mosquito   475 FAEVQETITGDDSIKYAMTTVNTLNAAFSAFDELIHSPMAYKVETVGKVYMAVSGAPDINPFHAQ 539

  Fly   485 EMSHLVPDLMKQEQMVKDSAVRDYMKFTLLAAQQQCGSVRSAAL--------FHLTRTRAP--SK 539
            .|:.|..|::.                          |:|...|        ||    ..|  :.
Mosquito   540 HMADLALDMLH--------------------------SIRQLNLPGVGVKIGFH----SGPIVAG 574

  Fly   540 VRPLKSKRYVL---------RMASTGGLDAYLIRRTSQLRLTK 573
            :..||..||.|         ||.|:|..|...:...:..:|.|
Mosquito   575 IVGLKVPRYCLFGDTVNTASRMESSGETDCIQVSGYTAQKLKK 617

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phlpp	NP_001260558.1	leucine-rich repeat	91..110	CDD:275380
		LRR_8	109..169	CDD:290566
		leucine-rich repeat	111..135	CDD:275380
		leucine-rich repeat	136..158	CDD:275380
		leucine-rich repeat	159..183	CDD:275380
		leucine-rich repeat	184..209	CDD:275380
		LRR_8	205..266	CDD:290566
		leucine-rich repeat	210..230	CDD:275380
		leucine-rich repeat	232..255	CDD:275380
		LRR_RI	<256..410	CDD:238064	22/89 (25%)
		leucine-rich repeat	256..276	CDD:275380
		LRR_8	279..359	CDD:290566	11/34 (32%)
		leucine-rich repeat	280..303	CDD:275380
		leucine-rich repeat	304..348	CDD:275380	8/23 (35%)
		leucine-rich repeat	349..372	CDD:275380	6/22 (27%)
		PP2Cc	461..655	CDD:294085	29/149 (19%)
AgaP_AGAP004564	XP_313866.5	HNOB	2..164	CDD:285002
		HNOBA	219..455	CDD:285003	24/109 (22%)
		CYCc	436..620	CDD:214485	40/212 (19%)
		Guanylate_cyc	466..643	CDD:278633	36/182 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900