DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Phlpp and AgaP_AGAP004555

DIOPT Version :9

Sequence 1:	NP_001260558.1	Gene:	Phlpp / 35178	FlyBaseID:	FBgn0032749	Length:	954	Species:	Drosophila melanogaster
Sequence 2:	XP_313853.4	Gene:	AgaP_AGAP004555 / 1274696	VectorBaseID:	AGAP004555	Length:	720	Species:	Anopheles gambiae

Alignment Length:	589	Identity:	122/589 - (20%)
Similarity:	202/589 - (34%)	Gaps:	169/589 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 EVTAAEEEQAATFGQTSPQKLSLKGSQLGGSILIGNYNYLTQLEVCENEMEVLDLSSLAQLETLK 95
            |..:|.||.|.|.                        |....|.|.:||...|....|.
Mosquito   182 ETISANEEMALTI------------------------NITRLLNVIQNERMSLVFYMLT------ 216

  Fly    96 CSRNKL-MELIINGTN--LQTLVADHNYLHNISTTNTHPVPLKLQRIDISHNN----------FS 147
             .:|:. :||.|..||  |..|..|.|||....|.| |.: :...||....|.          ::
Mosquito   217 -GKNRTQVELSIEHTNDALNHLGEDLNYLLPAGTAN-HTL-IADMRIKTPENETFTGLEYFEPYN 278

  Fly   148 ELPNWV--------GACASLTA----------INASHNRLNNVAVLLRNYRITELVSL-DLAY-- 191
            .|..:|        |...|.|.          |.|..: :|..|:|:..:.....:.| |.|.
Mosquito   279 ALNRYVINQIVRSTGTSISSTVWRQFVVYKNLIEAIES-INIAAILVLQFICNGYLGLSDYAQFI 342

  Fly   192 -NDLKQLDQFPEGFSSIRSLQLQSNELPSLPDNFFAVTHARLETL-NVSCN-KLSTLPRYEQNNH 253
             .|...||......:.:.||.:.|..      .|.|:.:.|.:.| |:|.. :...|..|..:..
Mosquito   343 RRDAAALDYIASAQNFMTSLSIISEA------EFSAMQYWRTQVLINISTGYRRDALVEYYHSVT 401

  Fly   254 AALVNLSLAGNHL----NDSIFEPLHNAAK-------LRVLHLAYNRIGVL----PAACVRNWP- 302
            ..|.||.:..:.:    .::|.|.:.:|.:       |.|:.|..:.|.||    ..:.::|:.
Mosquito   402 TVLKNLQMVQDQIQTDVKETILEEIQSARRHQSISIGLVVVILIISPILVLMIRAATSTIQNYST 466

  Fly   303 -----ELEILVLSGN----MLQQLPEEVATLGQLRVLR------------CCNNLLLCTPQLAKL 346
                 .:|:.:..|.    :.|.||.  |.:.||:..|            ..::::..|...|..
Mosquito   467 KLMARTMELRMEKGKSDRLLYQMLPP--AVVKQLKQQRQVPAETFDAVTIFFSDIVGFTDISASS 529

  Fly   347 AMLKVLDLSHNHLDRVNLLALVPSRNLKY----LDLSGNLQLQVDEQQFKVCQSQSQRH------ 401
            :.::|:.:.:      .|..|..|..|||    ::..|:..:.|.    .:.|....||
Mosquito   530 SAMEVVIMLN------TLYRLFDSIILKYDVYKVETIGDAYMVVS----GLPQRNGNRHAGEIAM 584

  Fly   402 WSLVDVSGNNRAALPTTKIRQVSAQRNQNKTSGPWTMG-----------FAET-------PGSGD 448
            .||..|.|.:...:|..|.|.:..:...|  :||...|           |.:|       ..:|:
Mosquito   585 MSLDLVCGISGFTIPHMKNRTLEIRVGIN--TGPCVAGVVGTTMPRYCLFGDTINTASRMESTGE 647

  Fly   449 CRKLSVYQLRAA---NYGGSDEALYGMFEALEGRGR------AAQEM-SHLVPDLMKQEQMVKDS 503
            ..|:.:.:....   ..||....|.|..: ::|:|.      ....| .||.|:::  ..|.|.:
Mosquito   648 PMKIHISESTKEVLDKLGGFKIKLRGTVD-VKGKGTMQTFWLTGHSMYEHLTPEML--IPMYKQN 709

  Fly   504 AVRD 507
            .|.:
Mosquito   710 VVTE 713

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phlpp	NP_001260558.1	leucine-rich repeat	91..110	CDD:275380	4/19 (21%)
		LRR_8	109..169	CDD:290566	21/89 (24%)
		leucine-rich repeat	111..135	CDD:275380	9/23 (39%)
		leucine-rich repeat	136..158	CDD:275380	6/39 (15%)
		leucine-rich repeat	159..183	CDD:275380	6/33 (18%)
		leucine-rich repeat	184..209	CDD:275380	6/28 (21%)
		LRR_8	205..266	CDD:290566	14/62 (23%)
		leucine-rich repeat	210..230	CDD:275380	4/19 (21%)
		leucine-rich repeat	232..255	CDD:275380	5/24 (21%)
		LRR_RI	<256..410	CDD:238064	39/200 (20%)
		leucine-rich repeat	256..276	CDD:275380	5/23 (22%)
		LRR_8	279..359	CDD:290566	19/112 (17%)
		leucine-rich repeat	280..303	CDD:275380	7/32 (22%)
		leucine-rich repeat	304..348	CDD:275380	11/59 (19%)
		leucine-rich repeat	349..372	CDD:275380	4/22 (18%)
		PP2Cc	461..655	CDD:294085	13/54 (24%)
AgaP_AGAP004555	XP_313853.4	NIT	<267..414	CDD:285564	30/153 (20%)
		HNOBA	<466..498	CDD:285003	6/33 (18%)
		CYCc	477..666	CDD:214485	37/202 (18%)
		Guanylate_cyc	504..690	CDD:278633	35/198 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900