DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Phlpp and AgaP_AGAP004485

DIOPT Version :9

Sequence 1:	NP_001260558.1	Gene:	Phlpp / 35178	FlyBaseID:	FBgn0032749	Length:	954	Species:	Drosophila melanogaster
Sequence 2:	XP_313783.5	Gene:	AgaP_AGAP004485 / 1274632	VectorBaseID:	AGAP004485	Length:	595	Species:	Anopheles gambiae

Alignment Length:	377	Identity:	96/377 - (25%)
Similarity:	158/377 - (41%)	Gaps:	58/377 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    64 IGNYNYLTQLEVCENEMEVL--DLSSLAQLETLKCSRNKLME--------------------LII 106
            ||....|..|.:.||.:..|  .|.:|.||:.|....|||.:                    :.:
Mosquito   156 IGCLANLKTLALNENSLTSLPDSLQNLKQLKVLDLRHNKLSDIPDVIYKLHTLTTLYLRFNRIRV 220

  Fly   107 NGTNLQTLVA------DHNYLHNISTTNTHPVPLKLQRIDISHNNFSELPNWVGACASLTAINAS 165
            .|.||:.|.:      ..|.:|.:.....|.|  .|..:|:|||:...||..:|.|.:|||::..
Mosquito   221 VGDNLKNLSSLTMLSLRENKIHELPAAIGHLV--NLTTLDLSHNHLKHLPEAIGNCVNLTALDLQ 283

  Fly   166 HNRLNNVAVLLRNYRITELVSLDLAYNDLKQLDQFPEGFSSIRSLQLQSNELPSLPDNFFAVTHA 230
            ||.|.::...:.|  ::.|:.|.|.||.|..:....:..:.:....::.|.:..|||...| :.:
Mosquito   284 HNDLLDIPESIGN--LSNLMRLGLRYNQLTSIPVSLKNCTHMDEFNVEGNGISQLPDGLLA-SLS 345

  Fly   231 RLETLNVSCNKLSTLPRYEQNNHAALVNLSLAGNHLNDSIFEPLHNAAKLRVLHLAYNRIGVLPA 295
            .|.|:.:|.|...:.|.........:.:::|..|.::...:.....|..|..|::..|.:..||.
Mosquito   346 NLTTITLSRNAFHSYPSGGPAQFTNVTSINLEHNQIDKIQYGIFSRAKGLTKLNMKENALTSLPL 410

  Fly   296 ACVRNWPELEILVLSGNMLQQLPEEVATLGQLRVLRCCNNLLLCTPQ-LAKLAMLKVLDLSHNHL 359
            . :..|.::..|....|.|.:||:::..|..|.:|...||||...|. :..|..|:||||..|.|
Mosquito   411 D-IGTWTQMVELNFGTNSLTKLPDDIHCLQNLEILILSNNLLKRIPNTIGNLKKLRVLDLEENRL 474

  Fly   360 DRV-----------------NLLALVPS-----RNLKYLDL-SGNLQLQVDE 388
            :.:                 |.|:.:|.     .||.||.: ..|||...:|
Mosquito   475 ESLPSEIGLLHDLQKLILQSNQLSALPRTIGHLTNLTYLSVGENNLQFLPEE 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phlpp	NP_001260558.1	leucine-rich repeat	91..110	CDD:275380	6/38 (16%)
		LRR_8	109..169	CDD:290566	21/65 (32%)
		leucine-rich repeat	111..135	CDD:275380	6/29 (21%)
		leucine-rich repeat	136..158	CDD:275380	9/21 (43%)
		leucine-rich repeat	159..183	CDD:275380	7/23 (30%)
		leucine-rich repeat	184..209	CDD:275380	6/24 (25%)
		LRR_8	205..266	CDD:290566	12/60 (20%)
		leucine-rich repeat	210..230	CDD:275380	5/19 (26%)
		leucine-rich repeat	232..255	CDD:275380	5/22 (23%)
		LRR_RI	<256..410	CDD:238064	41/157 (26%)
		leucine-rich repeat	256..276	CDD:275380	2/19 (11%)
		LRR_8	279..359	CDD:290566	26/80 (33%)
		leucine-rich repeat	280..303	CDD:275380	6/22 (27%)
		leucine-rich repeat	304..348	CDD:275380	14/44 (32%)
		leucine-rich repeat	349..372	CDD:275380	10/44 (23%)
		PP2Cc	461..655	CDD:294085
AgaP_AGAP004485	XP_313783.5	leucine-rich repeat	117..138	CDD:275380
		leucine-rich repeat	139..161	CDD:275380	2/4 (50%)
		LRR_RI	<161..241	CDD:238064	18/79 (23%)
		LRR_8	161..218	CDD:290566	13/56 (23%)
		leucine-rich repeat	162..184	CDD:275380	7/21 (33%)
		leucine-rich repeat	185..207	CDD:275380	5/21 (24%)
		LRR_8	207..264	CDD:290566	13/58 (22%)
		leucine-rich repeat	208..230	CDD:275380	4/21 (19%)
		leucine-rich repeat	231..253	CDD:275380	4/23 (17%)
		LRR_8	253..310	CDD:290566	21/58 (36%)
		leucine-rich repeat	254..276	CDD:275380	9/21 (43%)
		leucine-rich repeat	277..299	CDD:275380	7/23 (30%)
		LRR_RI	287..520	CDD:238064	55/236 (23%)
		leucine-rich repeat	300..322	CDD:275380	6/21 (29%)
		LRR_8	321..381	CDD:290566	12/60 (20%)
		leucine-rich repeat	323..344	CDD:275380	5/21 (24%)
		LRR_8	369..451	CDD:290566	19/82 (23%)
		leucine-rich repeat	371..394	CDD:275380	3/22 (14%)
		leucine-rich repeat	395..440	CDD:275380	12/45 (27%)
		leucine-rich repeat	418..433	CDD:275380	4/14 (29%)
		LRR_4	439..479	CDD:289563	15/39 (38%)
		LRR_8	440..497	CDD:290566	16/56 (29%)
		leucine-rich repeat	441..461	CDD:275380	7/19 (37%)
		leucine-rich repeat	464..486	CDD:275380	7/21 (33%)
		LRR_8	487..542	CDD:290566	11/40 (28%)
		leucine-rich repeat	487..509	CDD:275380	3/21 (14%)
		leucine-rich repeat	510..532	CDD:275380	7/17 (41%)
		leucine-rich repeat	533..556	CDD:275380
		leucine-rich repeat	557..577	CDD:275380
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910