DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Phlpp and AgaP_AGAP002998

DIOPT Version :9

Sequence 1:	NP_001260558.1	Gene:	Phlpp / 35178	FlyBaseID:	FBgn0032749	Length:	954	Species:	Drosophila melanogaster
Sequence 2:	XP_311887.5	Gene:	AgaP_AGAP002998 / 1272957	VectorBaseID:	AGAP002998	Length:	1153	Species:	Anopheles gambiae

Alignment Length:	679	Identity:	123/679 - (18%)
Similarity:	206/679 - (30%)	Gaps:	230/679 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 FGQTSPQKLSLKGSQLGGSILIGNYNYLTQLEVCENEMEV----LDLSSLAQLETLKCSRNKLME 103
            |..|:..|   |.:..||..:|..|...|.|.:...|..|    |.:|.:|           ||.
Mosquito   256 FSFTTSAK---KFTSSGGCTVIAIYIIYTMLPIRLREAVVGGSLLSISHIA-----------LMF 306

  Fly   104 LIINGTNLQTLVADHNYLHNISTTNTHPVPLKLQRIDISHNNFSELPNWVGACASLTAINASHNR 168
            .:....::..|..|   |..::.||...:.|...:.......|.|....|.|...:...|....:
Mosquito   307 YMNESDDVDVLYCD---LITLACTNATGILLHWPKEKSQRKAFMETRQCVEARLKIQRENQKQEQ 368

  Fly   169 L------NNVAVLLRN-------------YRITELVSLDLAYNDLKQLDQFPEGFSSIRSLQLQS 214
            |      .:||:.::|             ..|....::.:.:.|:.       ||:|: |.|..:
Mosquito   369 LLLSVLPRHVAMEMKNDIAGQPREAQFHKIYIQRHENVSILFADIC-------GFTSL-SDQCTA 425

  Fly   215 NELPSLPDNFFAVTHARLETLNVSCNKLSTLPRYEQNNHAALVNLSLAGNHLNDSIFEPLHNAAK 279
            .||..|.:..||                 ...|..|.:|...:.|      |.|..:
Mosquito   426 EELVRLLNELFA-----------------RFDRLAQEHHCLRIKL------LGDCYY-------- 459

  Fly   280 LRVLHLAYNRIGVLPAACVRNWPELEILVLSGNMLQQLPEEVATLGQLRVLRCCNNLLLCTPQLA 344
                             ||...||..            |:..                ||..::.
Mosquito   460 -----------------CVSGLPEAR------------PDHA----------------LCAVEMG 479

  Fly   345 KLAMLKVLDLSHNHLDRVNLLALVPSRNLKYLDLSGNLQLQVDEQQFKV-CQSQSQRHWSLVDVS 408
                          ||.::.:|||  |.:    ::.|:.::|.....:| |.....|.|.. ||.
Mosquito   480 --------------LDMIDAIALV--REV----MAVNVNMRVGIHTGRVHCGVLGLRKWQF-DVW 523

  Fly   409 GNNRAALPTTKIRQVSAQRNQNKTSGPWTMGFAETPGSGDCRKLSVYQLRAANYGGSDEALYGMF 473
            .|:            ....|..::.|        .||.....|.::            ..|...:
Mosquito   524 SND------------VTLANYMESGG--------VPGRVHITKETL------------RCLGDHY 556

  Fly   474 EALEGRGRAAQEMSHLVPDLMKQEQMV--KDSAVRDYMKFTLLAAQQQCGSVRS------AALFH 530
            :..||||  |...|:| .|...|..::  ||::.|.:      ...:|..||..      ..:.|
Mosquito   557 DVEEGRG--ADRNSYL-KDHQIQTYLIVPKDASYRPH------TMSKQSSSVNGNISKELRMMGH 612

  Fly   531 LTRTRAPSKVRPLKSK----RYVLRMASTGGLDAYLIRRTSQLRLTKPDVIQKDQIHSM----PD 587
            .::.....|..|..::    .|:::......:|...:....:..||    ..||:|...    ||
Mosquito   613 WSKMGFNDKTEPKSTEEEVNEYLIKAIDARSIDRLRLDHCKRFHLT----FIKDEIERKYCLEPD 673

  Fly   588 P-----------------HVLELILSNDD-EYLVVGNAQLWSVMD-IDRAAREIRKEENSLLAAK 633
            |                 .:..|:.|.|. .|.|.|...|..::. :....||..|......|..
Mosquito   674 PMLNVYFYCSIIIFLGIMSIQVLVFSMDHYSYWVYGILSLTLLVSCVPVFTREDMKVSTFFRALS 738

  Fly   634 RLV----DIAQSFAAAESLSVIVVRFRHL 658
            :.:    :|||..:....::||.:.:..|
Mosquito   739 QKIHGHREIAQVISLCVVITVICLSYYKL 767

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phlpp	NP_001260558.1	leucine-rich repeat	91..110	CDD:275380	2/18 (11%)
		LRR_8	109..169	CDD:290566	11/59 (19%)
		leucine-rich repeat	111..135	CDD:275380	5/23 (22%)
		leucine-rich repeat	136..158	CDD:275380	4/21 (19%)
		leucine-rich repeat	159..183	CDD:275380	6/42 (14%)
		leucine-rich repeat	184..209	CDD:275380	4/24 (17%)
		LRR_8	205..266	CDD:290566	12/60 (20%)
		leucine-rich repeat	210..230	CDD:275380	6/19 (32%)
		leucine-rich repeat	232..255	CDD:275380	3/22 (14%)
		LRR_RI	<256..410	CDD:238064	24/154 (16%)
		leucine-rich repeat	256..276	CDD:275380	3/19 (16%)
		LRR_8	279..359	CDD:290566	7/79 (9%)
		leucine-rich repeat	280..303	CDD:275380	2/22 (9%)
		leucine-rich repeat	304..348	CDD:275380	3/43 (7%)
		leucine-rich repeat	349..372	CDD:275380	5/22 (23%)
		PP2Cc	461..655	CDD:294085	45/232 (19%)
AgaP_AGAP002998	XP_311887.5	AC_N	<208..396	CDD:292831	32/156 (21%)
		CYCc	362..556	CDD:214485	51/330 (15%)
		Guanylate_cyc	398..554	CDD:278633	46/292 (16%)
		DUF1053	595..675	CDD:283888	15/83 (18%)
		CYCc	926..1127	CDD:214485
		Guanylate_cyc	952..1146	CDD:278633
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900