DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Phlpp and AgaP_AGAP000727

DIOPT Version :9

Sequence 1:	NP_001260558.1	Gene:	Phlpp / 35178	FlyBaseID:	FBgn0032749	Length:	954	Species:	Drosophila melanogaster
Sequence 2:	XP_559367.4	Gene:	AgaP_AGAP000727 / 1272318	VectorBaseID:	AGAP000727	Length:	2209	Species:	Anopheles gambiae

Alignment Length:	1108	Identity:	200/1108 - (18%)
Similarity:	357/1108 - (32%)	Gaps:	386/1108 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   106 INGTNLQTLVADHNYLHNISTTNTHPVPLKLQRIDISHNNFSELPNWVGACASLTAINASHNRLN 170
            :...|:.|.::||....|.:|.:   :|      .:.|...: ||.::       |::|:::.|:
Mosquito   765 VGQVNVFTCLSDHPCTTNFTTKS---IP------SVDHRKCA-LPQYI-------ALSAAYSFLS 812

  Fly   171 -----NVAVLLRNYRITELVSLDLAYNDLKQLDQFPEGFSSIRS-LQLQSNELPSLPDNFFAV-T 228
                 .:.:|::...:|.:..:...:.:|...:.|......:.| :.|.:..:..:.....|: .
Mosquito   813 VSIFLRLPILIKTVLVTLMALVYCLFIELSHANIFDCYDQRVESAIPLHTISVARILIFMIAILA 877

  Fly   229 HAR----------LETLNVSCNK--LSTLPRYEQNNHAALVNL--SLAGNHLNDSIFEPLHNAAK 279
            |.|          |..|..|..|  :|.|   :|:|...|.||  |....|..|:.| ...|.|.
Mosquito   878 HGRQVEWTARLDFLWQLQASQEKKEMSVL---QQSNRRILYNLLPSHVAAHFLDNQF-ARSNMAT 938

  Fly   280 LR--VLHLAYNRIGVLPAACVRNWPE-----------LEILVLSGNMLQQLPE-----------E 320
            :|  :.|.:|:::||: .|.|.|:.|           :|.|.|...::....|           :
Mosquito   939 MRQDLYHQSYSKVGVI-FASVPNFHEFYTELDGSNQGVECLRLLNEIIADFDELLCEERFHAIDK 1002

  Fly   321 VATLGQLRV----LRCCNNLLLCTPQLAKLAMLKVLDL---------------SHNHLDRVN--- 363
            :.|:|...:    |...:.:|...|...:..|..::|.               .:|.:.||.
Mosquito  1003 IKTVGSTYMAAVGLIPEHKMLPSEPGSMRRLMTALVDFVKAMRVTLKNINENSYNNFMLRVGVNV 1067

  Fly   364 ---LLALVPSRNLKYLDLSGNL------------------------QLQVDEQQFKVCQSQSQRH 401
               :..::.:|..:| |:.||.                        .||....:|: |:.|
Mosquito  1068 GPVVAGVIGARKPQY-DIWGNTVNVASRMDSTGIPGYTQVTQEVVDSLQGSHFEFR-CRGQ---- 1126

  Fly   402 WSLVDVSGNNRAALPTTKIRQVSAQRNQNK--TSGPWTMGFAETPGSGDCRKLSVYQLR------ 458
               :.|.|..      ..:.....::|:..  ..|..|.|.|...|.|......|.|.:
Mosquito  1127 ---IKVKGKG------DMVTYFLCEQNEQHLFAGGMVTNGLAGGGGGGGGASSVVQQQQQSVDAV 1182

  Fly   459 -----AANYGG-----SDEALYGMFEALEGRGRAAQEMSH----LVPD-----LMKQEQMVKDSA 504
                 .|..||     |..|:.....|..||.||.....|    :.|:     |::|:|.
Mosquito  1183 GSTAVLAMVGGTGTGESGGAMGASGNASLGRDRAGAAALHHQYMMAPNGNMAGLVQQQQQ----- 1242

  Fly   505 VRDYMKFTLLAAQQQCGSVRSAALFHLTRTRAPSKVRPLKSKRYVLRMASTGGLDAYLIRRTSQL 569
                       .|||.||     .||: :.|...:....|:.|:    ...||  :|..::.|..
Mosquito  1243 -----------QQQQLGS-----NFHM-KQRMEMEAATGKNGRW----QHDGG--SYSSKKESYN 1284

  Fly   570 RLTKPDVIQKDQIHSMPDPHVLELILSNDDEYLVVGNAQLWSVMDIDRAAREIRKEENSLLAAKR 634
            .|..|:::.:.|             .....:..:|.|.||           :::...|...|:|.
Mosquito  1285 FLESPNLLHQQQ-------------QQQQQQQQMVQNQQL-----------QMKHLHNQGQASKN 1325

  Fly   635 LVDIAQSFAAAESLSVIV--------------VRFRHLGTDVDHLIRE----------------- 668
            .:   |||...:|.|...              |..:|...:.:|::..
Mosquito  1326 SM---QSFHYPQSYSNPAQAAQPQQQQQVKGGVYKQHNNINNNHILSSSGFHHGLENYGKRNYDY 1387

  Fly   669 --------LKQSVRKKPQP----------VSLPLSSGSVCKR---------TCCDRSNACRHRAI 706
                    ...:.:::.||          |.||.:|.::.:.         |..|.:|..:|:.:
Mosquito  1388 HHHGQPGAAAAAHKQQEQPTSSQLGAGHGVQLPATSYNIRENFNIIENPNVTDLDENNFNQHQQL 1452

  Fly   707 EQEPLAGRSSPSG-----------------QSDRDLLAKDKDDEFVLAHA--------------- 739
              .||......:|                 .::|.|.|...::|.:|..|
Mosquito  1453 --LPLGRDHLNNGHKIRNHHHHQQQQEHHNSNNRGLYATASENEPLLGGASGGSGIIGNAIIKPI 1515

  Fly   740 -RVLQEEQQLEMLD-----ETESV--------------SESVL----------------SEEQFK 768
             ::.|::.|:.|.:     .|.||              |:..|                |::|..
Mosquito  1516 QQIQQQQHQIPMYEPPRYATTSSVFPHAISGQGYAYGMSQPALVRHQHMQQQQQQHHHHSKQQQP 1580

  Fly   769 CWEYMLEQNTQLLFDKELNTISKSFTKQRTVPNAIMAATVLPERNDFTSNLMRTVTNKFISTSTP 833
            .:.:..:|..|..:....:........|:.......:|:||               .::|. ..|
Mosquito  1581 AYIHQQQQQQQQQYSHPNHHHHNHHHHQQQQQQRQQSASVL---------------KQYIK-PLP 1629

  Fly   834 QLPQPITTSVPLGSYHQVKQAPPGHFGSALSFQQAHS---YGYNLFDAKPR---PKFH--GGTVK 890
            :||........|.|...:...|  |..|..|..:::|   .|.: ||.:|:   |.|.  ||...
Mosquito  1630 KLPTEYDECRELSSTDDLSSRP--HSPSVSSSDESYSKTTEGED-FDGEPQSPLPVFSTAGGAHA 1691

  Fly   891 RSAG----PNSAYF---------GSLQRLMPYNFE--YDFAVTQ---ERERNILDEEEHDDDDFN 937
            .:||    |...|.         .|..:|.|.:|.  .||.||.   |.:.:....:....:.|.
Mosquito  1692 NAAGGGGNPALQYLYPCDIQVDPTSPPKLSPIDFGNLRDFEVTSTTAETKSSSAHNKGESCNSFE 1756

  Fly   938 EHE 940
            .||
Mosquito  1757 YHE 1759

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phlpp	NP_001260558.1	leucine-rich repeat	91..110	CDD:275380	0/3 (0%)
		LRR_8	109..169	CDD:290566	12/59 (20%)
		leucine-rich repeat	111..135	CDD:275380	6/23 (26%)
		leucine-rich repeat	136..158	CDD:275380	3/21 (14%)
		leucine-rich repeat	159..183	CDD:275380	4/28 (14%)
		leucine-rich repeat	184..209	CDD:275380	2/24 (8%)
		LRR_8	205..266	CDD:290566	17/76 (22%)
		leucine-rich repeat	210..230	CDD:275380	2/20 (10%)
		leucine-rich repeat	232..255	CDD:275380	8/24 (33%)
		LRR_RI	<256..410	CDD:238064	43/228 (19%)
		leucine-rich repeat	256..276	CDD:275380	7/21 (33%)
		LRR_8	279..359	CDD:290566	21/122 (17%)
		leucine-rich repeat	280..303	CDD:275380	8/24 (33%)
		leucine-rich repeat	304..348	CDD:275380	9/58 (16%)
		leucine-rich repeat	349..372	CDD:275380	4/43 (9%)
		PP2Cc	461..655	CDD:294085	44/221 (20%)
AgaP_AGAP000727	XP_559367.4	AC_N	<17..264	CDD:292831
		CYCc	230..425	CDD:214485
		Guanylate_cyc	266..448	CDD:278633
		DUF1053	<621..680	CDD:283888
		CYCc	907..1123	CDD:214485	42/219 (19%)
		Guanylate_cyc	943..1140	CDD:278633	34/212 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900