DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Phlpp and AgaP_AGAP000054

DIOPT Version :9

Sequence 1:	NP_001260558.1	Gene:	Phlpp / 35178	FlyBaseID:	FBgn0032749	Length:	954	Species:	Drosophila melanogaster
Sequence 2:	XP_311104.5	Gene:	AgaP_AGAP000054 / 1272222	VectorBaseID:	AGAP000054	Length:	1593	Species:	Anopheles gambiae

Alignment Length:	508	Identity:	124/508 - (24%)
Similarity:	199/508 - (39%)	Gaps:	112/508 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    64 IGNYNYLTQLEVCENEMEVL--DLSSLAQLETLKCSRN----------KLMELIINGTNLQTLVA 116
            |.|:..|.:|:|..||:..:  |:..|..|:....|.|          :|..|.:.|.|..:|::
Mosquito    79 IQNFVNLVELDVSRNEIGDIPEDIKHLRSLQIADFSSNPISRLPAGFTQLRNLTVLGLNDMSLIS 143

  Fly   117 ----------------DHNYLHNISTTNTHPVPLKLQRIDISHNNFSELPNWVGACASLTAINAS 165
                            ..|.|.|:..:.:...  ||:|:|:..|...|||:.||...||..:...
Mosquito   144 LPQDFGCLSKLVSLELRENLLKNLPESISQLT--KLERLDLGDNEIDELPSHVGYLPSLQELWLD 206

  Fly   166 HNRLNNVAV---LLRNYRITELVSLDLAYNDLKQLDQFPEGFSSIRSLQLQSNELPSLPDNFFAV 227
            ||:|..:..   ||:     :||.||::.|.|::|.:...|...:..|.|..|.|.:||:....:
Mosquito   207 HNQLLRLPPEIGLLK-----KLVCLDVSENRLEELPEEIGGLECLTDLHLSQNLLETLPNGISKL 266

  Fly   228 THA--------RLETLN--VSC-----------NKLSTLPRYEQNNHAALVNLSLAGNHLNDSIF 271
            |:.        ||.|||  :.|           |.||.||. ...|...|.||::..|.| .::.
Mosquito   267 TNLSILKLDQNRLHTLNDSIGCCVHMQELILTENFLSELPA-TVGNMLVLNNLNVDRNSL-VAVP 329

  Fly   272 EPLHNAAKLRVLHLAYNRIGVLPAACVRNWPELEILVLSGNMLQQLPEEVATLGQLRVLRCCNNL 336
            ..|.|..:|.||.|..|::..|||. :.|..||.:|.:|||:||.||..:..| ||:.:....|.
Mosquito   330 SELGNCRQLGVLSLRENKLTRLPAE-LGNCGELHVLDVSGNLLQHLPYSLVNL-QLKAVWLSENQ 392

  Fly   337 LLCTPQLAKLAMLKVLDLSHNHLDRVNLLALVPSRNLKYLDLSGNLQLQVDEQQFKVCQSQSQRH 401
            ....|....       |:.....::|....|:|.:  :|:..:.:.:...|.:.::..::.....
Mosquito   393 SQPVPTFQP-------DVDETTNEQVLTCFLLPQQ--RYVPSNPSQREDTDSENWEEREASRTHS 448

  Fly   402 WSLVDVSGNNRAALPTTKIRQVSAQRNQNKTSGPWTMGFAETPGSGDCRKLSVYQLRAANYGGSD 466
            ....:..|.:|   .|..:||                   .||...:. |:..::|.|......|
Mosquito   449 VKFTEDFGADR---DTPFVRQ-------------------NTPHPKEL-KMKAHKLFAKERKSDD 490

  Fly   467 EALYGMFEAL-------------EGRGRAAQE--MSHLVPDLMKQEQMVKDSA 504
              |.|..:.|             .|.|.|..|  ..|.:|...:|.:....||
Mosquito   491 --LSGNLDTLSEESASRPSLLNRSGYGTATMEDIQGHAIPHDEEQGEAAAGSA 541

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phlpp	NP_001260558.1	leucine-rich repeat	91..110	CDD:275380	6/28 (21%)
		LRR_8	109..169	CDD:290566	19/75 (25%)
		leucine-rich repeat	111..135	CDD:275380	4/39 (10%)
		leucine-rich repeat	136..158	CDD:275380	9/21 (43%)
		leucine-rich repeat	159..183	CDD:275380	6/26 (23%)
		leucine-rich repeat	184..209	CDD:275380	8/24 (33%)
		LRR_8	205..266	CDD:290566	23/81 (28%)
		leucine-rich repeat	210..230	CDD:275380	7/19 (37%)
		leucine-rich repeat	232..255	CDD:275380	11/35 (31%)
		LRR_RI	<256..410	CDD:238064	37/153 (24%)
		leucine-rich repeat	256..276	CDD:275380	6/19 (32%)
		LRR_8	279..359	CDD:290566	25/79 (32%)
		leucine-rich repeat	280..303	CDD:275380	9/22 (41%)
		leucine-rich repeat	304..348	CDD:275380	14/43 (33%)
		leucine-rich repeat	349..372	CDD:275380	4/22 (18%)
		PP2Cc	461..655	CDD:294085	13/59 (22%)
AgaP_AGAP000054	XP_311104.5	leucine-rich repeat	16..38	CDD:275380
		LRR_RI	23..259	CDD:238064	49/186 (26%)
		LRR_8	38..95	CDD:290566	6/15 (40%)
		leucine-rich repeat	39..58	CDD:275380
		leucine-rich repeat	62..84	CDD:275380	2/4 (50%)
		LRR_8	84..138	CDD:290566	13/53 (25%)
		leucine-rich repeat	85..107	CDD:275380	7/21 (33%)
		leucine-rich repeat	108..130	CDD:275380	4/21 (19%)
		leucine-rich repeat	131..176	CDD:275380	7/46 (15%)
		LRR_8	152..210	CDD:290566	17/59 (29%)
		leucine-rich repeat	177..199	CDD:275380	9/21 (43%)
		LRR_8	198..256	CDD:290566	18/62 (29%)
		leucine-rich repeat	200..222	CDD:275380	6/26 (23%)
		leucine-rich repeat	223..245	CDD:275380	8/21 (38%)
		LRR_8	246..300	CDD:290566	13/53 (25%)
		leucine-rich repeat	246..268	CDD:275380	6/21 (29%)
		LRR_8	315..371	CDD:290566	22/57 (39%)
		leucine-rich repeat	315..337	CDD:275380	7/22 (32%)
		leucine-rich repeat	361..382	CDD:275380	10/21 (48%)
		PDZ	766..854	CDD:214570
		PDZ_signaling	943..1032	CDD:238492
		PDZ_signaling	1139..1228	CDD:238492
		PDZ_signaling	1238..1327	CDD:238492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910