DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Phlpp and TOLL10

DIOPT Version :9

Sequence 1:	NP_001260558.1	Gene:	Phlpp / 35178	FlyBaseID:	FBgn0032749	Length:	954	Species:	Drosophila melanogaster
Sequence 2:	XP_309458.4	Gene:	TOLL10 / 1270739	VectorBaseID:	AGAP011187	Length:	1347	Species:	Anopheles gambiae

Alignment Length:	731	Identity:	171/731 - (23%)
Similarity:	259/731 - (35%)	Gaps:	222/731 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 TRKQADPYKSKLKVSASHSGPHPLPVEVTAAEEEQAATFGQTSPQKLSLKGSQLGGSILIGNYNY 69
            :|....|...|.:.....:|....|..||.....:..|.|.|.....:|...|      |...|.
Mosquito    27 SRMDVAPRGCKWQRVLDETGEEEAPATVTTVLSCKLKTIGATDTLMRNLSSYQ------IERINS 85

  Fly    70 LTQLEVCE----------NEMEVLDLSSLAQLETLKCS--RNKLMELIINGT--NLQTL-VADHN 119
            | :||..:          |:.....|.||.:|..||..  :.|.:..::..|  :|::| :..||
Mosquito    86 L-RLECSDILFFESSLEANQHSGAFLGSLRRLRDLKIEYCKIKYVPSMVLATLRDLRSLSLRTHN 149

  Fly   120 YLHNISTTNTHPVPLK----LQRIDISHNNFSELPNWVGACA--SLTAINASHNRLNNVAVL--- 175
            ...:......||...:    |:|:|::.||...||..| .|.  ||..:|.:.|||.:|:.|
Mosquito   150 TDWSAMNLEFHPESFRGLTELKRLDLADNNIWALPTDV-FCPLFSLRHLNLTRNRLTDVSQLGFS 213

  Fly   176 -----------LRNYRITELVSLDLAYNDLKQLDQFPEGFSSIRS---LQLQSNELPSLPDNFFA 226
                       ..|   |.|..|||::|||..|..  .|.||:||   |.||.|.|.:|.|..|
Mosquito   214 DWGNGPTAPGKACN---TGLEVLDLSHNDLLALPD--NGLSSLRSLSVLMLQDNLLTALADRSF- 272

  Fly   227 VTHARLETLNVSCNKLSTLPRYEQNNHAALVNLSLAGNHLNDSIFEPLHNAAKLRVLHLAYNRIG 291
            |....|:.||:|.|||..||.                        |...:..:||.::|..|.:.
Mosquito   273 VGLGSLKVLNMSSNKLVALPP------------------------ETFQSTRELRQIYLQNNSLS 313

  Fly   292 VLPAACVRNWPELEILVLSGNMLQQLPEE------VATLGQLRVLRCCNNLLLCTPQ--LAKLAM 348
            ||....:.....||||.||.|   :|..|      .|.:.:|.||...:|.|....:  ..:|..
Mosquito   314 VLAPGMLEGLDRLEILDLSHN---ELTSEWVKRNTFAGMKRLVVLEIAHNALTKIDRHVFRELYS 375

  Fly   349 LKVLDLSHNHLDRVNLLALVPSRNLKYLDLSGNLQLQVDEQQFKVCQSQSQRHWSLVDVSGNNRA 413
            |::|:|..|.::.:...|....:||..|.||.|...:::           |.|:|.:.|
Mosquito   376 LQILNLEANQIESIADNAFSDLKNLVALTLSHNRLKRIE-----------QHHFSELYV------ 423

  Fly   414 ALPTTKIRQVSAQRNQNKTSGPWTMGFAETPGSGDCRKLSVYQLRAANYGGSDEALYGMFEALEG 478
                  :.|:..:.|                                           :.|::
Mosquito   424 ------LNQLYVESN-------------------------------------------LIESM-- 437

  Fly   479 RGRAAQEMSHLVPDLMKQEQMVKDSAVRDYMKFTLLAAQQQCGSVRSAALFHLTRTRAPSKVRPL 543
            .|||.:.:::|           .|..:.|.   .|....:..|.:|......|.:.|..:
Mosquito   438 HGRALENLTNL-----------NDLNLNDN---RLTEIPEGLGKLRFLKSLDLGKNRISA----- 483

  Fly   544 KSKRYVLRMASTGGLDAYLIRRTSQLRLTKPDVIQKDQIHSMPDPHVLELILSNDDEYLVVGNAQ 608
                  :..||..||:..|..|..:.|:|.   |.:|...::...|||.| .||
Mosquito   484 ------VSNASFEGLEQLLGLRLVENRITN---ISRDAFVTLSSLHVLNL-ASN----------- 527

  Fly   609 LWSVMDIDRAA-------REIRKEENSLLAAKRLVDIAQSFAAAESLSVIVVRFRHLGTDVDHLI 666
              .:..||::|       |.||.:.|      .|.||:..|.:..:|..:.|.        |:.|
Mosquito   528 --QIRHIDQSAFSSNPTIRAIRLDNN------ELEDISGVFTSLPALVFLNVS--------DNQI 576

  Fly   667 RELKQSVRKKPQPVSL 682
            |....|    ..||||
Mosquito   577 RLFDYS----HFPVSL 588

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phlpp	NP_001260558.1	leucine-rich repeat	91..110	CDD:275380	5/22 (23%)
		LRR_8	109..169	CDD:290566	20/68 (29%)
		leucine-rich repeat	111..135	CDD:275380	6/24 (25%)
		leucine-rich repeat	136..158	CDD:275380	9/23 (39%)
		leucine-rich repeat	159..183	CDD:275380	8/37 (22%)
		leucine-rich repeat	184..209	CDD:275380	11/24 (46%)
		LRR_8	205..266	CDD:290566	22/63 (35%)
		leucine-rich repeat	210..230	CDD:275380	9/19 (47%)
		leucine-rich repeat	232..255	CDD:275380	9/22 (41%)
		LRR_RI	<256..410	CDD:238064	38/161 (24%)
		leucine-rich repeat	256..276	CDD:275380	1/19 (5%)
		LRR_8	279..359	CDD:290566	26/87 (30%)
		leucine-rich repeat	280..303	CDD:275380	6/22 (27%)
		leucine-rich repeat	304..348	CDD:275380	16/51 (31%)
		leucine-rich repeat	349..372	CDD:275380	5/22 (23%)
		PP2Cc	461..655	CDD:294085	41/200 (21%)
TOLL10	XP_309458.4	LRR_RI	94..364	CDD:238064	87/303 (29%)
		leucine-rich repeat	116..139	CDD:275380	5/22 (23%)
		LRR_8	140..204	CDD:290566	19/64 (30%)
		leucine-rich repeat	170..193	CDD:275380	9/23 (39%)
		LRR_8	193..288	CDD:290566	37/100 (37%)
		leucine-rich repeat	194..229	CDD:275380	8/37 (22%)
		leucine-rich repeat	230..253	CDD:275380	11/24 (46%)
		leucine-rich repeat	254..277	CDD:275380	9/23 (39%)
		LRR_8	277..336	CDD:290566	23/85 (27%)
		leucine-rich repeat	278..301	CDD:275380	10/46 (22%)
		leucine-rich repeat	302..325	CDD:275380	6/22 (27%)
		leucine-rich repeat	326..351	CDD:275380	10/27 (37%)
		LRR_8	350..410	CDD:290566	17/59 (29%)
		leucine-rich repeat	352..375	CDD:275380	6/22 (27%)
		LRR_4	375..414	CDD:289563	11/38 (29%)
		leucine-rich repeat	376..399	CDD:275380	5/22 (23%)
		LRR_8	398..>441	CDD:290566	14/110 (13%)
		leucine-rich repeat	400..470	CDD:275380	20/151 (13%)
		LRR_RI	<462..697	CDD:238064	41/173 (24%)
		LRR_8	471..529	CDD:290566	18/85 (21%)
		leucine-rich repeat	471..494	CDD:275380	6/33 (18%)
		leucine-rich repeat	495..518	CDD:275380	6/25 (24%)
		LRR_8	517..576	CDD:290566	20/86 (23%)
		leucine-rich repeat	519..542	CDD:275380	9/36 (25%)
		leucine-rich repeat	543..563	CDD:275380	8/25 (32%)
		leucine-rich repeat	566..587	CDD:275380	7/32 (22%)
		LRR_8	587..644	CDD:290566	2/2 (100%)
		leucine-rich repeat	610..633	CDD:275380
		leucine-rich repeat	634..657	CDD:275380
		leucine-rich repeat	658..677	CDD:275380
		TPKR_C2	695..752	CDD:301599
		leucine-rich repeat	813..834	CDD:275378
		LRR_8	833..893	CDD:290566
		LRR_4	833..876	CDD:289563
		leucine-rich repeat	835..858	CDD:275378
		LRR_RI	<852..957	CDD:238064
		leucine-rich repeat	859..882	CDD:275378
		leucine-rich repeat	883..906	CDD:275378
		leucine-rich repeat	907..918	CDD:275378
		TIR_2	1086..1224	CDD:304906
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910