DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Phlpp and AgaP_AGAP011292

DIOPT Version :9

Sequence 1:	NP_001260558.1	Gene:	Phlpp / 35178	FlyBaseID:	FBgn0032749	Length:	954	Species:	Drosophila melanogaster
Sequence 2:	XP_309356.4	Gene:	AgaP_AGAP011292 / 1270641	VectorBaseID:	AGAP011292	Length:	1292	Species:	Anopheles gambiae

Alignment Length:	926	Identity:	204/926 - (22%)
Similarity:	339/926 - (36%)	Gaps:	260/926 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    64 IGNYNYLTQLEVCENEMEVL--DLSSLAQLETLKCSRNKLMELIINGTNLQTLVADHNYLHNIST 126
            :|....|..|.:..|::|.|  .||.|..|.:|...||||
Mosquito    52 MGKLVKLEHLSMKNNQLEKLFGQLSELGCLRSLNVRRNKL------------------------- 91

  Fly   127 TNTHPVPL------KLQRIDISHNNFSELPNWVGACASLTAINASHNRLNNVAVLLRNYRITELV 185
             .:|.:|.      :|..:|:|||...|:|..:....:|..:|.|:|::..:...| ...:|:|:
Mosquito    92 -KSHAIPSDLFELEELTTLDLSHNRLKEVPEGLEKAKALLVLNLSNNQIETIPPSL-FINLTDLL 154

  Fly   186 SLDLAYNDLKQLDQFPEGFSSIRSLQLQSN--------ELPSLP--------------DNFFAV- 227
            .|||:.|.|:.|.......|::::|.|..|        :||||.              :||.|.
Mosquito   155 FLDLSNNKLETLPPQTRRLSNLQTLILNDNPLELFQLRQLPSLQSLVCLQMRNTQRTINNFPASL 219

  Fly   228 -THARLETLNVSCNKLSTLPRYEQNNHAALVNL-SLAGNHLNDSIFEPL----HNAAKLRVLHLA 286
             :.:.|:.|::|.|.||.:|       .||.|| :|...:|||::.|.|    .|..||..|:|:
Mosquito   220 DSLSNLQELDLSQNALSKVP-------GALYNLANLKRLNLNDNVLEELSPLIENLTKLETLNLS 277

  Fly   287 YNRIGVLPAACVRNWPELEILVLSGNML--QQLPEEVATLGQLRVLRCCNNLLLCTPQ-LAK-LA 347
            .|::..|||...: ..||..|.::.|:|  :.:|..:..|..|.|....||.|...|: |.: ..
Mosquito   278 RNKLTALPATLCK-LQELRRLYVNDNLLNFEGIPSSIGKLSALEVFSASNNELEMVPEGLCRGCG 341

  Fly   348 MLKVLDLSHNHL----DRVNLLALVPSRNLKYLDLSGNLQLQVDEQQFKVCQSQSQRHWSL---- 404
            .||.|:||.|.|    :.::||.     :::.|||..|..|.:..:..:..:.....::::
Mosquito   342 SLKKLNLSSNKLITLPEAIHLLT-----DMEQLDLRNNPDLVMPPKPIEAQRGDGLAYYNIDFSL 401

  Fly   405 ------------VDVSGNNRAALP--TTKIRQVSAQRN-------------------QNKTSGPW 436
                        ..|.|...|...  ..|:|.....||                   ::|.||
Mosquito   402 QTQLRLAGANVPAQVQGAANAGKDPIARKLRLRRGARNDSSDNQDSAKILKGMQDIAKDKNSG-- 464

  Fly   437 TMGFAETPGSGDCRKLSVYQLRAANYGGSDEAL------YG-MFEALEGR--GRAAQEMSHLVPD 492
             :||.|.         .|..|:...:   ||.|      |. :||..:|:  |....|:.:.:|:
Mosquito   465 -LGFGEE---------KVENLKPKRW---DETLEKPPVDYSEIFEDEDGQYPGLTVWEIENFLPN 516

  Fly   493 LMKQEQMVKDSAVRDYMKFTLLAAQQQCGSVRSAALFHL-TRT----RAPSKVRPLKSKRYV--- 549
              |.|:..............|..:....|.:.....|.: |:.    ||.|.:..:..:.|:
Mosquito   517 --KIEEAAHGKFYEGDCYIVLKTSHDDSGQLSWEIYFWIGTKATLDKRACSAIHAVNLRNYLGAR 579

  Fly   550 ---LRMASTGGLDAYLI-----------RRTSQLRLTKPDVIQKDQIHSMPD--PHV-LELI--- 594
               :|.......|.:|.           .|||....|..:.:...:::.:.|  |:: ||.:
Mosquito   580 CRTIREEQGDESDEFLALFDSDVTYIEGGRTSTGFYTIENAVYIVRLYRVHDAGPNIHLEPVPVS 644

  Fly   595 -LSNDDEY---LVVG-NAQLW----SVMDIDRAAR----EIRKEENSLLAAKRLVDIAQSFAAAE 646
             .|.|..|   |..| |..:|    |...:...||    :|.|.|.     |...:|.|.:...|
Mosquito   645 YQSLDPGYVFLLDTGLNIFVWYGTRSKNTLKSKARFTAEKINKHER-----KNKAEIYQEYQRQE 704

  Fly   647 SLSVIVVRFRHLG--------------TDVDHLIRE------------LKQSVRKKPQPVSLPLS 685
            ||..    :|.||              .:..|:..|            |.....:.|| |.||
Mosquito   705 SLDF----WRALGFADGQGPQDEEAECLNQSHVDPEFVPVPPRLYQIQLGMGYLELPQ-VELP-- 762

  Fly   686 SGSVCKRTCCDRSNACRHRAIEQEPLAGRSSPSGQSDRDLLA--KDKDDEFVLAHARVLQEE--- 745
             |..|.:|            :....||.::........||..  ..|....|.|.|..|.:|
Mosquito   763 -GGGCNKT------------LTHTILASKNVYILDCYLDLFVWFGKKSTRLVRAAAIKLSQELFS 814

  Fly   746 ----QQLEMLDETESVSESVLSEEQFKCWEYMLEQNTQLLFDKELNTISKS------FTKQRTVP 800
                ....|:...:..:|:.:.:.:|..||.::..:    |.:...:::::      :.||:..
Mosquito   815 MIDRPDYAMITRVQEGTETQVFKSKFTGWEEIIAVD----FTRTAQSVARTGADLTQWAKQQQT- 874

  Fly   801 NAIMAATVLPERNDFT 816
            .|.:||..:|.:...|
Mosquito   875 KADLAALFMPRQPAMT 890

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phlpp	NP_001260558.1	leucine-rich repeat	91..110	CDD:275380	6/18 (33%)
		LRR_8	109..169	CDD:290566	13/65 (20%)
		leucine-rich repeat	111..135	CDD:275380	2/29 (7%)
		leucine-rich repeat	136..158	CDD:275380	7/21 (33%)
		leucine-rich repeat	159..183	CDD:275380	5/23 (22%)
		leucine-rich repeat	184..209	CDD:275380	8/24 (33%)
		LRR_8	205..266	CDD:290566	23/85 (27%)
		leucine-rich repeat	210..230	CDD:275380	10/43 (23%)
		leucine-rich repeat	232..255	CDD:275380	7/22 (32%)
		LRR_RI	<256..410	CDD:238064	47/182 (26%)
		leucine-rich repeat	256..276	CDD:275380	9/24 (38%)
		LRR_8	279..359	CDD:290566	28/83 (34%)
		leucine-rich repeat	280..303	CDD:275380	7/22 (32%)
		leucine-rich repeat	304..348	CDD:275380	13/47 (28%)
		leucine-rich repeat	349..372	CDD:275380	9/26 (35%)
		PP2Cc	461..655	CDD:294085	50/243 (21%)
AgaP_AGAP011292	XP_309356.4	LRR_8	33..91	CDD:290566	13/38 (34%)
		leucine-rich repeat	35..57	CDD:275380	1/4 (25%)
		leucine-rich repeat	58..80	CDD:275380	8/21 (38%)
		leucine-rich repeat	81..105	CDD:275380	8/49 (16%)
		LRR_RI	100..353	CDD:238064	77/261 (30%)
		LRR_8	105..163	CDD:290566	18/58 (31%)
		leucine-rich repeat	106..128	CDD:275380	7/21 (33%)
		leucine-rich repeat	129..152	CDD:275380	5/23 (22%)
		leucine-rich repeat	153..175	CDD:275380	7/21 (33%)
		LRR_8	156..235	CDD:290566	21/78 (27%)
		leucine-rich repeat	176..224	CDD:275380	10/47 (21%)
		LRR_8	223..281	CDD:290566	23/64 (36%)
		leucine-rich repeat	225..247	CDD:275380	11/28 (39%)
		leucine-rich repeat	248..270	CDD:275380	7/21 (33%)
		LRR_8	269..353	CDD:290566	28/84 (33%)
		leucine-rich repeat	271..293	CDD:275380	7/22 (32%)
		leucine-rich repeat	294..318	CDD:275380	6/23 (26%)
		leucine-rich repeat	319..342	CDD:275380	7/22 (32%)
		gelsolin_S1_like	497..608	CDD:200446	17/112 (15%)
		gelsolin_like	625..712	CDD:200436	24/95 (25%)
		gelsolin_S3_like	742..840	CDD:200448	21/113 (19%)
		gelsolin_like	971..1050	CDD:200436
		gelsolin_S5_like	1073..1176	CDD:200444
		gelsolin_S6_like	1187..1285	CDD:200447
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910