DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Phlpp and TOLL1A

DIOPT Version :9

Sequence 1:	NP_001260558.1	Gene:	Phlpp / 35178	FlyBaseID:	FBgn0032749	Length:	954	Species:	Drosophila melanogaster
Sequence 2:	XP_309197.1	Gene:	TOLL1A / 1270495	VectorBaseID:	AGAP001004	Length:	1152	Species:	Anopheles gambiae

Alignment Length:	1056	Identity:	220/1056 - (20%)
Similarity:	360/1056 - (34%)	Gaps:	345/1056 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 AEEEQAATF------GQTSPQKLSLKGSQLG--GSILIGNYNYLTQLEVCEN--EMEVLDLSSLA 89
            |..||:|:.      |.....:|::..::|.  |..|..:...||.|::.:|  .:......:|.
Mosquito   142 ANHEQSASLVRHHFAGLDQLDRLAISNAKLSDIGPDLFEHLPNLTWLDMRDNIFRLPATIFDALP 206

  Fly    90 QLETLKCSRNKLME----LIINGTNLQTLVADHNYLHNISTTNTHPVPLKLQRIDISHNNFSELP 150
            :|..|:.|.|.|.|    |:.:..||:.|...||.|..:|......|| :|:|:|:|.|....:|
Mosquito   207 KLRVLELSFNSLEELDPRLLRHLPNLRLLTLWHNKLRTLSRAAFAGVP-ELERLDLSSNQLESVP 270

  Fly   151 NWVGACASLTAINASHNRLNNVAVLLRNYRITELVSLDLAYNDLKQLDQFPEGF----SSIRSLQ 211
            .         .:.|....|..:|:.:.|:|                  ..|:|.    ..:|.::
Mosquito   271 G---------DLFADLPHLTELAMGVNNFR------------------TLPDGLFRANRELRKVK 308

  Fly   212 LQSN--ELPSLPDNFFAVTHARLETLNVSCNKLSTLPRYEQNNHAALVNLSLAGNHLNDSIFEPL 274
            |.|.  ||.:||.:...:..| |:.:::....|.:||.......|.|..|:||.|.|:....:.|
Mosquito   309 LASQRVELETLPHDLLQMLPA-LDQVSLERVGLVSLPGTLLFGSANLTQLNLANNRLHQLPEDLL 372

  Fly   275 HNAAKLRVLHLAYNRIGVLPAACVRNWPELEILVLSGNMLQQLPEEVATLGQLRVLRCCNNLLLC 339
            .:...|:||.|.:|::..|||..:||..||..|.||.|.          :|:|..:
Mosquito   373 RDQKALQVLQLQHNQLTGLPAGLLRNTVELHTLRLSHNQ----------IGELSAV--------- 418

  Fly   340 TPQLAKLAMLKVLDLSHNHLDRVNLLALVPSRNLKYLDLSGNLQLQVDEQQFKVC---------- 394
              .|..|..|:.|.|.||.|..:.|.|...:..|.      .|.|||::..|:..
Mosquito   419 --ALQALTKLQELYLDHNQLYTIELHAFKQTTALH------TLHLQVNQLAFETLNTLPATAPDT 475

  Fly   395 --QSQSQRH------WSL----------------VDVSGNNRAALP------TTKIRQVSAQRNQ 429
              |.|...|      :||                :|:|.|...|:|      |.::::::..||
Mosquito   476 GDQEQLTDHIPAPDEFSLLAQDGTPFQHLHQLRELDLSSNWLTAVPRDLLLNTHELQRLNLTRN- 539

  Fly   430 NKTSGPW-TMGFAETPGSGDCRKLSVYQLRAANYGGSDEALYGM----FEALEGRGRAAQEMSHL 489
            |.||..: .:.|.....:.|.|..|::::..|:.    |.|..:    |:...||.|.....:.|
Mosquito   540 NITSLTYANLQFLAPAITVDLRHNSIFEIDLADM----ERLVLLEPRNFDEQTGRARVLLNDNPL 600

  Fly   490 VPDLMKQ--EQMVKDS-AVRDYMKFTLLAAQQQCGSVR--SAALFHLTRTR-------APS-KVR 541
            ..:.:..  .|.:::. |...|.:|.|:|.:..|....  ..||.....||       .|| .:|
Mosquito   601 HCNCIAYAFAQYIQNRLATAVYDRFELVANELTCHGPEHLEGALIKDVPTRELLCELDTPSTAIR 665

  Fly   542 --PLKSKRYVLRMASTGGLDAYLIRRTSQLRLTKPDVIQKDQIHSMPDP-----HVLELILSNDD 599
              |...:.|: |...||     :|...|...||        ::..:|.|     ..:||.|.|::
Mosquito   666 HCPAPCRCYI-RPEDTG-----VIIDCSGQALT--------EVPELPRPTTFGYRFIELHLENNN 716

  Fly   600 -----EYLVVGNAQLWSVMDIDRAAREIRKEENSLLA--------AKRLVD------------IA 639
                 :......:..|:      ..||:....||:.|        :.||:|            :|
Mosquito   717 ISALPDSTTASGSSGWA------EVRELYASNNSIAALAADQLPRSLRLLDLSRNRLTTLDGPLA 775

  Fly   640 QSFAAAESLSVIVVRFRH----LGTDVDHLIRELKQSVRKKPQPVSLPLSSGSVCKR-----TCC 695
            :|..|:.:|:  .||..|    ...:...|:.....:.|:......|..|.|...::     .|.
Mosquito   776 ESLTASTTLT--TVRLAHNDWTCQCETTQLLTFAHANQRRIEDFGRLRCSDGRPLEQMTLSDLCV 838

  Fly   696 DRSN------------ACRHRA-------------------------IEQEPLAGRSSPSGQSDR 723
            ||::            ||...|                         :.:|.|          ||
Mosquito   839 DRTHMIVLTCVIVSVVACLVAALSLVYYTYKLELKVWLFKHGLCLWLVAEEEL----------DR 893

  Fly   724 DLL------AKDKDDEFVLAHARVLQEEQQLEMLDETESVSESVLSEEQFK-CWEYMLEQNTQLL 781
            |.|      ...||:.|:..|.....|...:                 .|| ||........:::
Mosquito   894 DKLYDAFVSYSHKDEAFITEHLVPTLERDPM-----------------NFKLCWHVRDWTPGEMI 941

  Fly   782 FDKELNTISKSFTKQRTVPNAIMAATVLPERNDFTSNLMRTVTNKFISTSTPQLPQPITTSVPLG 846
            ..:    ||.|..:.|        .|::...:.|..:|.
Mosquito   942 SSQ----ISSSVEQSR--------RTIIVLSSSFLESLW-------------------------- 968

  Fly   847 SYHQVKQAPPGHFGSALSFQQAH--------------SYG--YNLFDAKP--RPKFHGGTVKRSA 893
                          ..|.|:.||              .||  .|::|.:|  |...|..|..|..
Mosquito   969 --------------GQLEFRTAHLQSMAERRNRLIIIIYGDIGNIYDLEPELRAYLHTNTYVRWG 1019

  Fly   894 GPNSAYFGSLQRLMPY 909
            .|  .::..|:..||:
Mosquito  1020 DP--WFWDKLRFAMPH 1033

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phlpp	NP_001260558.1	leucine-rich repeat	91..110	CDD:275380	7/22 (32%)
		LRR_8	109..169	CDD:290566	16/59 (27%)
		leucine-rich repeat	111..135	CDD:275380	8/23 (35%)
		leucine-rich repeat	136..158	CDD:275380	6/21 (29%)
		leucine-rich repeat	159..183	CDD:275380	5/23 (22%)
		leucine-rich repeat	184..209	CDD:275380	2/28 (7%)
		LRR_8	205..266	CDD:290566	18/62 (29%)
		leucine-rich repeat	210..230	CDD:275380	6/21 (29%)
		leucine-rich repeat	232..255	CDD:275380	4/22 (18%)
		LRR_RI	<256..410	CDD:238064	48/187 (26%)
		leucine-rich repeat	256..276	CDD:275380	7/19 (37%)
		LRR_8	279..359	CDD:290566	25/79 (32%)
		leucine-rich repeat	280..303	CDD:275380	10/22 (45%)
		leucine-rich repeat	304..348	CDD:275380	9/43 (21%)
		leucine-rich repeat	349..372	CDD:275380	8/22 (36%)
		PP2Cc	461..655	CDD:294085	50/242 (21%)
TOLL1A	XP_309197.1	LRR_8	<153..193	CDD:290566	8/39 (21%)
		leucine-rich repeat	163..184	CDD:275380	4/20 (20%)
		LRR_RI	<176..412	CDD:238064	71/274 (26%)
		leucine-rich repeat	185..207	CDD:275380	5/21 (24%)
		LRR_8	206..266	CDD:290566	21/60 (35%)
		leucine-rich repeat	208..231	CDD:275380	7/22 (32%)
		leucine-rich repeat	232..255	CDD:275380	8/23 (35%)
		LRR_8	254..311	CDD:290566	16/84 (19%)
		leucine-rich repeat	256..279	CDD:275380	7/31 (23%)
		leucine-rich repeat	280..353	CDD:275380	18/91 (20%)
		leucine-rich repeat	304..329	CDD:275380	7/24 (29%)
		LRR_8	328..388	CDD:290566	18/60 (30%)
		leucine-rich repeat	330..351	CDD:275380	4/20 (20%)
		LRR_RI	351..580	CDD:238064	65/260 (25%)
		leucine-rich repeat	354..377	CDD:275380	7/22 (32%)
		LRR_8	378..436	CDD:290566	25/78 (32%)
		leucine-rich repeat	378..401	CDD:275380	10/22 (45%)
		leucine-rich repeat	402..425	CDD:275380	9/43 (21%)
		leucine-rich repeat	426..449	CDD:275380	8/22 (36%)
		leucine-rich repeat	450..468	CDD:275380	6/23 (26%)
		LRR_8	506..565	CDD:290566	14/59 (24%)
		leucine-rich repeat	507..530	CDD:275380	6/22 (27%)
		leucine-rich repeat	549..576	CDD:275380	6/30 (20%)
		LRRNT	666..702	CDD:214470	11/49 (22%)
		leucine-rich repeat	691..734	CDD:275380	9/56 (16%)
		LRR_8	709..767	CDD:290566	13/63 (21%)
		leucine-rich repeat	735..756	CDD:275380	5/20 (25%)
		TIR	897..1034	CDD:214587	33/208 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910