DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Phlpp and AgaP_AGAP007048

DIOPT Version :9

Sequence 1:	NP_001260558.1	Gene:	Phlpp / 35178	FlyBaseID:	FBgn0032749	Length:	954	Species:	Drosophila melanogaster
Sequence 2:	XP_308715.4	Gene:	AgaP_AGAP007048 / 1270053	VectorBaseID:	AGAP007048	Length:	942	Species:	Anopheles gambiae

Alignment Length:	905	Identity:	191/905 - (21%)
Similarity:	310/905 - (34%)	Gaps:	315/905 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 PVEVTAAEEEQAATFGQTSPQKLSLKGS-QLGGSILIGNYNYLTQLEVCENEMEV---------- 82
            |...::.||..|......:...:...|: :|....|:.:|..||.|::......:
Mosquito    31 PTSTSSEEETNAGVIFSNATTLIIEDGALELIDPALLESYPNLTHLQLSPRVRSIQPNAFASLKA 95

  Fly    83 -----LD-----------LSSLAQLETLKCSRNKLMELIING------TNLQTLVADHNYLHNIS 125
                 ||           ||:|:.|:||..: |.|:|.:.:|      ..||:|..|.|.:|.:
Mosquito    96 LTNLNLDNNLFATVPREALSALSTLKTLSIA-NNLLESLDDGDVFLSLARLQSLSLDSNLIHQL- 158

  Fly   126 TTNTHPVPLKLQRIDISHNNFSELPNWVGACASLTAINASHNRL---NNVAVLLRNYRITELVSL 187
                ||            .:|:.|       |.|..:|.|.|||   .::.:...|    :|..|
Mosquito   159 ----HP------------QSFARL-------AELKLLNVSWNRLTAFESIILPPEN----QLQVL 196

  Fly   188 DLAYNDLKQLD-----QFPEGFSSIRSLQLQSNELPSLPDNFFAVTHARLETLNVSCNKLSTLPR 247
            ||:||.:|.|:     :.|    ::|.|.|..|:..||..|.|| |...|..|::|.|...:||.
Mosquito   197 DLSYNYVKLLNVSTFHRLP----ALRELSLAGNQFESLHPNTFA-TLRHLSRLDLSDNFFQSLPP 256

  Fly   248 YEQNNHAALVNLSLAGNHLNDSIFEPLHNAAK-LRVLHLAYNRIGVLPAACVRNWPELEILVLSG 311
            ....::..||.|:||.| |.|::...|....| |..|:|..||:..|||...|..|....|.|.|
Mosquito   257 RLFTSNRKLVELNLAAN-LLDTLPGDLFAGLKHLTALNLRNNRLTELPATIFREQPPFAQLALEG 320

  Fly   312 NMLQQLPEEVATLGQLRVLRCCNNLLLCTPQLAKL------------------------------ 346
            |.:::.|.:        .|:...::||...:||.|
Mosquito   321 NRIERFPSD--------WLQASADVLLQNNRLAGLRKFAPSANGTVVRRLFLYGNEIATVEQDVF 377

  Fly   347 ---AMLKVLDLSHNHLDRVNLLALVPSRNLKYLDLSGNLQLQVDEQQFKVCQSQSQRHWSLVDVS 408
               ..|:.|.|.:|.:|.::.:....:..|:::.||.|....:....|   ...::.|  .||:|
Mosquito   378 RAVPKLETLYLDYNRIDELSPMVFHTNHELQHVTLSHNRLAVLRTNTF---AGLARLH--SVDLS 437

  Fly   409 GNNRAALPT-----TKIRQVSAQRNQNKTSGPWTMGFAETPGSG--------DCRKLSVYQLRAA 460
            .|..||:..     :.:..::...|:.:|...|:.       ||        |...:...|:..|
Mosquito   438 YNRLAAIEESVFHGSPVEYLNLNGNRLRTLDEWSF-------SGTRLLYLYVDSNAIDAVQVGGA 495

  Fly   461 NYGGSDEALYGMFEALEGRGR-------AAQEMSHL---------VPDLMKQEQMVKDSAVRDYM 509
            ...|.:..|.|:.|......|       .|:..|.|         :|.|.:....:.:....|.:
Mosquito   496 GGRGEEGVLEGLVELSVASNRLDRWQELCARNFSRLSALNLANNSLPSLERASGCLGERTNLDPL 560

  Fly   510 -------KFTLLAAQQQCGSVRS-----------------------------------------A 526
                   |.:|:  .:..|.|||                                         |
Mosquito   561 TVNVGLNKVSLI--PEFAGPVRSLDLSGNSVEDLEGGHRFERYQQTEVLLLRNTSLRALNSGNFA 623

  Fly   527 ALFHLTRTRAPSK---------VRPLKSKRYVLRMASTGGLDAYLI---RRTSQLRLTKPDV--- 576
            .|.:||.....||         :..||.:|..|..:....|.::|:   |..|.|.|...::
Mosquito   624 FLPYLTELAVSSKFLETIEEDTLLGLKLQRLELTDSPLKTLPSHLLKAQRNLSYLSLANNELTVL 688

  Fly   577 ---------------------------------------IQKDQIHSM------PDPHVLELILS 596
                                                   ::.::|..:      ||.|.|||:
Mosquito   689 FSTFFTDCVRLEVMDFSGNALSTADKAWFEPLEHLKSINLEANRITQLPADLLSPDTHALELL-- 751

  Fly   597 NDDEYLVVGNAQLWSVMD----IDRAAREI-----RKEENSLLAAKRLVDIAQSFAAAESLSVIV 652
                 .|.||| |.:|.|    .|...:.:     |.||.:|||....  |.|...:...|..::
Mosquito   752 -----SVAGNA-LHTVSDAAFLADVPIKALNLSNNRLEEVTLLARNEF--ITQLDVSGNRLKRLL 808

  Fly   653 VR--FRHLGTDV-------------------------DHLIRELKQSVRKKPQPVSLPLS 685
            :|  :|.|..:|                         |:|:.:|.|.|.:....|:|.:|
Mosquito   809 LRPNYRTLVANVNQISSLEWDRHYHAKSCQLELLYLADNLLEQLDQRVFQLATMVALDVS 868

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phlpp	NP_001260558.1	leucine-rich repeat	91..110	CDD:275380	7/24 (29%)
		LRR_8	109..169	CDD:290566	15/59 (25%)
		leucine-rich repeat	111..135	CDD:275380	8/23 (35%)
		leucine-rich repeat	136..158	CDD:275380	2/21 (10%)
		leucine-rich repeat	159..183	CDD:275380	7/26 (27%)
		leucine-rich repeat	184..209	CDD:275380	9/29 (31%)
		LRR_8	205..266	CDD:290566	22/60 (37%)
		leucine-rich repeat	210..230	CDD:275380	9/19 (47%)
		leucine-rich repeat	232..255	CDD:275380	6/22 (27%)
		LRR_RI	<256..410	CDD:238064	45/187 (24%)
		leucine-rich repeat	256..276	CDD:275380	9/19 (47%)
		LRR_8	279..359	CDD:290566	26/113 (23%)
		leucine-rich repeat	280..303	CDD:275380	9/22 (41%)
		leucine-rich repeat	304..348	CDD:275380	11/76 (14%)
		leucine-rich repeat	349..372	CDD:275380	5/22 (23%)
		PP2Cc	461..655	CDD:294085	58/328 (18%)
AgaP_AGAP007048	XP_308715.4	leucine-rich repeat	50..72	CDD:275380	4/21 (19%)
		leucine-rich repeat	73..95	CDD:275380	3/21 (14%)
		LRR_8	118..179	CDD:290566	22/85 (26%)
		leucine-rich repeat	120..144	CDD:275380	7/24 (29%)
		LRR_RI	121..369	CDD:238064	80/290 (28%)
		leucine-rich repeat	145..168	CDD:275380	10/46 (22%)
		leucine-rich repeat	169..192	CDD:275380	7/26 (27%)
		LRR_8	192..249	CDD:290566	22/61 (36%)
		leucine-rich repeat	193..216	CDD:275380	9/26 (35%)
		leucine-rich repeat	217..240	CDD:275380	10/23 (43%)
		LRR_8	239..299	CDD:290566	20/60 (33%)
		leucine-rich repeat	241..264	CDD:275380	6/22 (27%)
		leucine-rich repeat	265..288	CDD:275380	9/23 (39%)
		leucine-rich repeat	289..312	CDD:275380	9/22 (41%)
		leucine-rich repeat	313..349	CDD:275380	11/43 (26%)
		leucine-rich repeat	350..382	CDD:275380	0/31 (0%)
		LRR_8	381..441	CDD:290566	15/64 (23%)
		leucine-rich repeat	383..406	CDD:275380	5/22 (23%)
		leucine-rich repeat	407..430	CDD:275380	5/25 (20%)
		LRR_8	430..487	CDD:290566	13/65 (20%)
		leucine-rich repeat	431..451	CDD:275380	7/21 (33%)
		leucine-rich repeat	455..476	CDD:275380	5/27 (19%)
		leucine-rich repeat	477..506	CDD:275380	5/28 (18%)
		leucine-rich repeat	507..530	CDD:275380	3/22 (14%)
		leucine-rich repeat	579..603	CDD:275380	3/23 (13%)
		LRR_RI	581..>804	CDD:238064	40/232 (17%)
		leucine-rich repeat	604..627	CDD:275380	2/22 (9%)
		leucine-rich repeat	628..650	CDD:275380	4/21 (19%)
		leucine-rich repeat	651..674	CDD:275380	4/22 (18%)
		LRR_8	673..733	CDD:290566	4/59 (7%)
		leucine-rich repeat	675..698	CDD:275380	3/22 (14%)
		leucine-rich repeat	699..722	CDD:275380	0/22 (0%)
		LRR_8	722..782	CDD:290566	15/67 (22%)
		leucine-rich repeat	723..747	CDD:275380	3/23 (13%)
		leucine-rich repeat	748..771	CDD:275380	11/30 (37%)
		leucine-rich repeat	772..794	CDD:275380	6/23 (26%)
		LRR_8	838..896	CDD:290566	8/31 (26%)
		leucine-rich repeat	839..861	CDD:275380	5/21 (24%)
		leucine-rich repeat	862..885	CDD:275380	3/7 (43%)
		leucine-rich repeat	886..909	CDD:275380
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910