DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Phlpp and AgaP_AGAP002262

DIOPT Version :9

Sequence 1:	NP_001260558.1	Gene:	Phlpp / 35178	FlyBaseID:	FBgn0032749	Length:	954	Species:	Drosophila melanogaster
Sequence 2:	XP_307919.5	Gene:	AgaP_AGAP002262 / 1269297	VectorBaseID:	AGAP002262	Length:	1384	Species:	Anopheles gambiae

Alignment Length:	210	Identity:	43/210 - (20%)
Similarity:	72/210 - (34%)	Gaps:	55/210 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    93 TLKCSRNKLMELIINGTNLQTLVADHNY---------LHNISTTNTHPVPLKLQRIDISHNNFSE 148
            |..||...:::...|..|..|..:::|:         :|...|| |..:|      :|...|.:|
Mosquito   591 TATCSGGSVVQHNHNNNNNNTTSSNNNHITKRTSKSTIHEDETT-TDWIP------EIPFKNLNE 648

  Fly   149 LPNWVGACASLTAINASHNRLNNVAVLLRNYRITELVSLDLAYNDLKQL-------------DQF 200
            ....|.|..|..  :..|.  :...|......:.|::...:..|..||:             |..
Mosquito   649 CGGGVNAAESFR--DKKHT--DREDVFTSTEEVDEMIDQSIQINSNKQIRQEYLYTWTLKFKDSS 709

  Fly   201 PEG-FSSIRSLQLQSNEL--------------PSLPDNFFAVTHARLET--LNVSC-----NKLS 243
            .|| |..:|....:||.|              ..:|.....:....:.|  |.|.|     .:.|
Mosquito   710 QEGTFCQLREDMFRSNMLCVFVVWIFIVLCQAVIIPRCTILIVALSITTFLLTVGCILVMAEEFS 774

  Fly   244 TLPRYEQNNHAALVN 258
            .||::.|.:.:.||:
Mosquito   775 GLPKFLQQSSSTLVH 789

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phlpp	NP_001260558.1	leucine-rich repeat	91..110	CDD:275380	4/16 (25%)
		LRR_8	109..169	CDD:290566	15/68 (22%)
		leucine-rich repeat	111..135	CDD:275380	7/32 (22%)
		leucine-rich repeat	136..158	CDD:275380	5/21 (24%)
		leucine-rich repeat	159..183	CDD:275380	2/23 (9%)
		leucine-rich repeat	184..209	CDD:275380	7/38 (18%)
		LRR_8	205..266	CDD:290566	15/75 (20%)
		leucine-rich repeat	210..230	CDD:275380	4/33 (12%)
		leucine-rich repeat	232..255	CDD:275380	8/29 (28%)
		LRR_RI	<256..410	CDD:238064	2/3 (67%)
		leucine-rich repeat	256..276	CDD:275380	2/3 (67%)
		LRR_8	279..359	CDD:290566
		leucine-rich repeat	280..303	CDD:275380
		leucine-rich repeat	304..348	CDD:275380
		leucine-rich repeat	349..372	CDD:275380
		PP2Cc	461..655	CDD:294085
AgaP_AGAP002262	XP_307919.5	AC_N	<82..334	CDD:292831
		CYCc	309..513	CDD:214485
		Guanylate_cyc	350..516	CDD:278633
		DUF1053	631..721	CDD:283888	21/100 (21%)
		CYCc	1020..1218	CDD:214485
		Guanylate_cyc	1045..1240	CDD:278633
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900