DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Phlpp and LRRK2

DIOPT Version :9

Sequence 1:	NP_001260558.1	Gene:	Phlpp / 35178	FlyBaseID:	FBgn0032749	Length:	954	Species:	Drosophila melanogaster
Sequence 2:	NP_940980.4	Gene:	LRRK2 / 120892	HGNCID:	18618	Length:	2527	Species:	Homo sapiens

Alignment Length:	684	Identity:	137/684 - (20%)
Similarity:	257/684 - (37%)	Gaps:	175/684 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 SLKGSQLGG--------SILIGNYNYLTQLEVCENEMEVLDLSSLAQLETLKCSRNKLMELIING 108
            ||:.|:|..        |.|.....|:|.|::..||:.  |:.:|:|    ||..:..:|
Human   958 SLRSSKLQSHMRHSDSISSLASEREYITSLDLSANELR--DIDALSQ----KCCISVHLE----- 1011

  Fly   109 TNLQTLVADHNYLHNISTTNTHPVPL-----KLQRIDISHNNFSELPNWVGACASLTAINASHNR 168
             :|:.|....|.|      .:.|..|     .|..:|:..|.|:..|:::...:.:..::.|.|.
Human  1012 -HLEKLELHQNAL------TSFPQQLCETLKSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRND 1069

  Fly   169 LNNVAVLLRNYRITELVSLDLAYNDL-----------KQLDQF------------PEGFSSIRSL 210
            :....||....:...|...:|:||.|           ::|:|.            |.....::.|
Human  1070 IGPSVVLDPTVKCPTLKQFNLSYNQLSFVPENLTDVVEKLEQLILEGNKISGICSPLRLKELKIL 1134

  Fly   211 QLQSNELPSLPDNFFAVTHARLETLNVSCNKLSTLP---------RYEQNNHAALVNLSLAGNHL 266
            .|..|.:.||.:||.... .::|:.:...|.|:.:|         :..||..:.:....|...||
Human  1135 NLSKNHISSLSENFLEAC-PKVESFSARMNFLAAMPFLPPSMTILKLSQNKFSCIPEAILNLPHL 1198

  Fly   267 -------NDSIF--EPLH-NAAKLRVLHLAYNRIGVLP-AACVRNWPELEILVLSGNMLQQLPEE 320
                   ||..:  .|.| .:..||.|..::|:|.:|. :.....|..:|.|.||.|.|:::|.|
Human  1199 RSLDMSSNDIQYLPGPAHWKSLNLRELLFSHNQISILDLSEKAYLWSRVEKLHLSHNKLKEIPPE 1263

  Fly   321 VATLGQLRVLRCCNNLLLCT--PQLAKLAMLKVLDLSHNHLDRVNLLALVPSRNLKYLDLSGNLQ 383
            :..|..|..|....||.|.:  .::.||:  |:.||.   ||.::|     :.:.|::.......
Human  1264 IGCLENLTSLDVSYNLELRSFPNEMGKLS--KIWDLP---LDELHL-----NFDFKHIGCKAKDI 1318

  Fly   384 LQVDEQQFKVCQSQSQRHWSLVDVSGNNRAALPTTKIRQVSAQRN-----QNKTSG----PWTMG 439
            ::..:|:.|.....::....:|..:|:.:    ||.::|:...:.     |:.|.|    .|.:.
Human  1319 IRFLQQRLKKAVPYNRMKLMIVGNTGSGK----TTLLQQLMKTKKSDLGMQSATVGIDVKDWPIQ 1379

  Fly   440 FAETPGSGDCRKLSVYQLRAANYGGSDE------------ALY-GMFEALEG------------- 478
            ..      |.||..:. |...::.|.:|            ||| .:::..:|
Human  1380 IR------DKRKRDLV-LNVWDFAGREEFYSTHPHFMTQRALYLAVYDLSKGQAEVDAMKPWLFN 1437

  Fly   479 -RGRAAQE--------------------MSHLVPDLMKQEQMVKDSAVRDYMKFTLLAAQQQCGS 522
             :.||:..                    ||.:..:|:.:...   .|:|||..............
Human  1438 IKARASSSPVILVGTHLDVSDEKQRKACMSKITKELLNKRGF---PAIRDYHFVNATEESDALAK 1499

  Fly   523 VRSAAL-----FHLTRTRAPSKVRP---LKSKRYVLRMASTGGLDAYLIRRTSQLRLTKPDVIQK 579
            :|...:     |.:.......::.|   ::.::.:|.......::..:|.|...|:|.:.:.:|.
Human  1500 LRKTIINESLNFKIRDQLVVGQLIPDCYVELEKIILSERKNVPIEFPVIDRKRLLQLVRENQLQL 1564

  Fly   580 DQ------IHSMPDPHVL----ELILSNDDEYLV 603
            |:      :|.:.:..||    :..|...|.|.|
Human  1565 DENELPHAVHFLNESGVLLHFQDPALQLSDLYFV 1598

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phlpp	NP_001260558.1	leucine-rich repeat	91..110	CDD:275380	3/18 (17%)
		LRR_8	109..169	CDD:290566	13/64 (20%)
		leucine-rich repeat	111..135	CDD:275380	6/28 (21%)
		leucine-rich repeat	136..158	CDD:275380	5/21 (24%)
		leucine-rich repeat	159..183	CDD:275380	4/23 (17%)
		leucine-rich repeat	184..209	CDD:275380	8/47 (17%)
		LRR_8	205..266	CDD:290566	14/69 (20%)
		leucine-rich repeat	210..230	CDD:275380	7/19 (37%)
		leucine-rich repeat	232..255	CDD:275380	6/31 (19%)
		LRR_RI	<256..410	CDD:238064	40/166 (24%)
		leucine-rich repeat	256..276	CDD:275380	7/29 (24%)
		LRR_8	279..359	CDD:290566	26/82 (32%)
		leucine-rich repeat	280..303	CDD:275380	7/23 (30%)
		leucine-rich repeat	304..348	CDD:275380	16/45 (36%)
		leucine-rich repeat	349..372	CDD:275380	6/22 (27%)
		PP2Cc	461..655	CDD:294085	32/208 (15%)
LRRK2	NP_940980.4	Required for RAB29-mediated activation. /evidence=ECO:0000269\|PubMed:29212815	1..969		4/10 (40%)
		LRR 1	983..1004		8/26 (31%)
		leucine-rich repeat	985..1012	CDD:275380	10/38 (26%)
		LRR	1012..>1286	CDD:227223	64/280 (23%)
		LRR 2	1012..1033		6/26 (23%)
		leucine-rich repeat	1013..1036	CDD:275380	6/28 (21%)
		LRR 3	1036..1057		5/20 (25%)
		leucine-rich repeat	1037..1084	CDD:275380	9/46 (20%)
		LRR 4	1059..1080		4/20 (20%)
		LRR 5	1084..1105		5/20 (25%)
		leucine-rich repeat	1085..1108	CDD:275380	5/22 (23%)
		LRR 6	1108..1129		3/20 (15%)
		leucine-rich repeat	1109..1130	CDD:275380	3/20 (15%)
		LRR 7	1130..1150		7/19 (37%)
		leucine-rich repeat	1131..1174	CDD:275380	11/43 (26%)
		LRR 8	1174..1196		3/21 (14%)
		leucine-rich repeat	1175..1197	CDD:275380	3/21 (14%)
		LRR 9	1197..1218		6/20 (30%)
		leucine-rich repeat	1198..1221	CDD:275380	5/22 (23%)
		LRR 10	1221..1241		6/19 (32%)
		leucine-rich repeat	1222..1246	CDD:275380	7/23 (30%)
		LRR 11	1246..1267		8/20 (40%)
		leucine-rich repeat	1247..1269	CDD:275380	9/21 (43%)
		LRR 12	1269..1291		5/21 (24%)
		RocCOR	1334..1507	CDD:206741	29/186 (16%)
		COR	1527..1740	CDD:318343	14/72 (19%)
		STKc_LRRK2	1884..2135	CDD:270970
		WD 1	2139..2183
		WD 2	2188..2228
		WD 3	2233..2276
		WD 4	2281..2327
		WD 5	2333..2377
		WD 6	2402..2438
		WD 7	2443..2497
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900