DRSC/TRiP Functional Genomics Resources

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Protein Alignment Phlpp and LRG1

DIOPT Version :9

Sequence 1:NP_001260558.1 Gene:Phlpp / 35178 FlyBaseID:FBgn0032749 Length:954 Species:Drosophila melanogaster
Sequence 2:NP_443204.1 Gene:LRG1 / 116844 HGNCID:29480 Length:347 Species:Homo sapiens


Alignment Length:308 Identity:93/308 - (30%)
Similarity:130/308 - (42%) Gaps:54/308 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly   147 SELPNWVGACASLTAI---NASHNRLNNVAVLLRNYRITELVSLDLAYNDLKQLD-QFPEGFSSI 207
            :|:|.::.|.....|:   |.:|...|    ||:.  .::|..|.|:.|.|:.|. :|......:
Human    60 AEIPGYLPADTVHLAVEFFNLTHLPAN----LLQG--ASKLQELHLSSNGLESLSPEFLRPVPQL 118

  Fly   208 RSLQLQSNELPSLPDNFFAVTHARLETLNVSCNKLSTLPRYEQNNHAALVNLSLAGNHLNDSIFE 272
            |.|.|..|.|..||...|..: |.|:||.:..|:|..|.....:...||.:|.|:||.|......
Human   119 RVLDLTRNALTGLPPGLFQAS-ATLDTLVLKENQLEVLEVSWLHGLKALGHLDLSGNRLRKLPPG 182

  Fly   273 PLHNAAKLRVLHLAYNRIGVLPAACVRNWPELEILVLSGNMLQQLPEEVATLGQLRVLRCCNNLL 337
            .|.|...||.|.|..|::..||...:|...:||.|.|.||.||.|.::               ||
Human   183 LLANFTLLRTLDLGENQLETLPPDLLRGPLQLERLHLEGNKLQVLGKD---------------LL 232

  Fly   338 LCTPQLAKLAMLKVLDLSHNHLDRVNLLALVPSRNLKYLDLSGNLQLQVDEQQFKVCQSQSQRHW 402
            |..|.      |:.|.|:.|.|.||...|....|.|..||||.|....|.|   .:..|..|.:|
Human   233 LPQPD------LRYLFLNGNKLARVAAGAFQGLRQLDMLDLSNNSLASVPE---GLWASLGQPNW 288

  Fly   403 SL---VDVSGN------NRAALPTTKIRQVSAQR------NQNKTSGP 435
            .:   .|:|||      |.:.|    .|.:.||:      |..:.:||
Human   289 DMRDGFDISGNPWICDQNLSDL----YRWLQAQKDKMFSQNDTRCAGP 332

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PhlppNP_001260558.1 leucine-rich repeat 91..110 CDD:275380
LRR_8 109..169 CDD:290566 6/24 (25%)
leucine-rich repeat 111..135 CDD:275380
leucine-rich repeat 136..158 CDD:275380 3/10 (30%)
leucine-rich repeat 159..183 CDD:275380 6/26 (23%)
leucine-rich repeat 184..209 CDD:275380 7/25 (28%)
LRR_8 205..266 CDD:290566 21/60 (35%)
leucine-rich repeat 210..230 CDD:275380 7/19 (37%)
leucine-rich repeat 232..255 CDD:275380 6/22 (27%)
LRR_RI <256..410 CDD:238064 51/156 (33%)
leucine-rich repeat 256..276 CDD:275380 7/19 (37%)
LRR_8 279..359 CDD:290566 25/79 (32%)
leucine-rich repeat 280..303 CDD:275380 8/22 (36%)
leucine-rich repeat 304..348 CDD:275380 13/43 (30%)
leucine-rich repeat 349..372 CDD:275380 8/22 (36%)
PP2Cc 461..655 CDD:294085
LRG1NP_443204.1 LRR_8 79..128 CDD:290566 16/54 (30%)
LRR_RI <82..248 CDD:238064 60/193 (31%)
LRR 1 93..114 7/20 (35%)
leucine-rich repeat 94..117 CDD:275380 7/22 (32%)
LRR_8 116..176 CDD:290566 21/60 (35%)
LRR 2 117..138 8/20 (40%)
leucine-rich repeat 118..141 CDD:275380 8/23 (35%)
LRR 3 141..162 6/20 (30%)
leucine-rich repeat 142..165 CDD:275380 6/22 (27%)
LRR 4 165..186 8/20 (40%)
leucine-rich repeat 166..189 CDD:275380 8/22 (36%)
LRR_8 169..224 CDD:290566 21/54 (39%)
LRR 5 189..210 7/20 (35%)
leucine-rich repeat 190..213 CDD:275380 8/22 (36%)
LRR_8 213..272 CDD:290566 28/79 (35%)
LRR 6 213..234 11/35 (31%)
leucine-rich repeat 214..237 CDD:275380 12/37 (32%)
LRR 7 237..258 8/26 (31%)
leucine-rich repeat 238..261 CDD:275380 8/22 (36%)
LRR 8 261..282 8/23 (35%)
leucine-rich repeat 262..285 CDD:275380 9/25 (36%)
LRRCT 299..346 CDD:214507 9/38 (24%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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