DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Phlpp and Adcy7

DIOPT Version :9

Sequence 1:	NP_001260558.1	Gene:	Phlpp / 35178	FlyBaseID:	FBgn0032749	Length:	954	Species:	Drosophila melanogaster
Sequence 2:	XP_006530643.1	Gene:	Adcy7 / 11513	MGIID:	102891	Length:	1146	Species:	Mus musculus

Alignment Length:	650	Identity:	125/650 - (19%)
Similarity:	211/650 - (32%)	Gaps:	189/650 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   181 ITELVSLDLAYNDLKQLDQFPEGFSSIR-SLQLQSNELPSLPDNFFAVTHAR--------LETLN 236
            :|..||..|.:..:.:  .|....||.: .|||.:|.:..|..||....|..        |....
Mouse   152 VTSTVSHLLVFGAVTR--AFQTSMSSTQLGLQLLANAVILLGGNFTGAFHKHQLQDASRDLFIYT 214

  Fly   237 VSCNKLSTLPRYEQNNHAALVNLSLAGNHLN---------------DSIFEPLHNAAKLRVLHLA 286
            |.|.::....|.|:.....|: ||:...|::               |..:.|.:|...|.|..
Mouse   215 VKCIQIRRKLRVEKRQQENLL-LSVLPAHISMGMKLAIIERLKEGGDRHYMPDNNFHSLYVKR-- 276

  Fly   287 YNRIGVLPAACV------RNWPELEILVLSGNMLQQLPEEVATLGQ---LRVL----RCCNNLLL 338
            :..:.:|.|..|      .:....|::|:...:..:. :::|...:   :::|    .|.:.|.:
Mouse   277 HQNVSILYADIVGFTRLASDCSPKELVVVLNELFGKF-DQIAKANECMRIKILGDCYYCVSGLPV 340

  Fly   339 CTPQLAKLAMLKVLDLSHNHLDRVNLLALVPSRNLKYLDL-------SGNLQLQVDEQQFKVCQS 396
            ..|..|:..:...||:..         |:...|....:|:       |||:          :|..
Mouse   341 SLPTHARNCVKMGLDICE---------AIKQVREATGVDISMRVGIHSGNV----------LCGV 386

  Fly   397 QSQRHWSL----VDVSGNNRAALPTTKIRQVSAQRNQNKTSGPWTMGFAETPGSGDCRKLSVYQL 457
            ...|.|..    .|||..||                         |..|..||.        ..:
Mouse   387 IGLRKWQYDVWSHDVSLANR-------------------------MEAAGVPGR--------VHI 418

  Fly   458 RAANYGGSDEALYGMFEALEGRGRA----AQEM---SHLVPDLMKQE------QMVK---DSAVR 506
            ..|.....|:|    :|..:|.|..    .:||   ::||.|...|:      .:.|   |:.::
Mouse   419 TEATLNHLDKA----YEVEDGHGEQRDPYLKEMNIRTYLVIDPRSQQPPPPSHHLSKPKGDATLK 479

  Fly   507 DYMKFTLLAAQQQCGSVRSAALFHLTRTRAPS------------KVRPLKSKRYVLRMASTGG-- 557
            ......:....:..|:.|..|  ||....:.|            |..||:..|...|.||..|
Mouse   480 MRASVRVTRYLESWGAARPFA--HLNHRESVSSSETPISNGRRQKAIPLRRHRAPDRSASPKGRL 542

  Fly   558 ---LDAYLIRRTSQLRLTKPDVIQKDQIHSMPDPHVLELILSNDDEYLVVGNAQLWSVMDIDRAA 619
               .|..::.....|..|:|...:.|..|:. .|..||           .|..:.:.::.|.||.
Mouse   543 EDDCDDEMLSAIEGLSSTRPCCSKSDDFHTF-GPIFLE-----------KGFEREYRLVPIPRAR 595

  Fly   620 REIRKEE--------NSLLAAKRLVDIAQSFAAAESLSVIVVRFRHLGTDVDH------LIRELK 670
            .:.....        ..||...|:..:..||.....|..:|:.| ...|:...      .::.:.
Mouse   596 YDFACASLVFVCILLVHLLVMPRMATLGVSFGLVACLLGLVLSF-CFATEFSRCFPSRSTLQAIS 659

  Fly   671 QSVRKKP--QPVSLPLSSGSVCKRTCCDRSNACRHRAIEQEPLA---GRSSPSGQSDRDLLAKDK 730
            :||..:|  :.|.:.|:.||:..            .||...||.   |...|.......|.|:::
Mouse   660 ESVETQPLVRLVLVVLTVGSLLT------------VAIINMPLTLNPGPEQPGDNKTSPLAAQNR 712

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phlpp	NP_001260558.1	leucine-rich repeat	91..110	CDD:275380
		LRR_8	109..169	CDD:290566
		leucine-rich repeat	111..135	CDD:275380
		leucine-rich repeat	136..158	CDD:275380
		leucine-rich repeat	159..183	CDD:275380	0/1 (0%)
		leucine-rich repeat	184..209	CDD:275380	6/25 (24%)
		LRR_8	205..266	CDD:290566	18/69 (26%)
		leucine-rich repeat	210..230	CDD:275380	7/19 (37%)
		leucine-rich repeat	232..255	CDD:275380	5/22 (23%)
		LRR_RI	<256..410	CDD:238064	34/192 (18%)
		leucine-rich repeat	256..276	CDD:275380	6/34 (18%)
		LRR_8	279..359	CDD:290566	15/92 (16%)
		leucine-rich repeat	280..303	CDD:275380	5/28 (18%)
		leucine-rich repeat	304..348	CDD:275380	8/50 (16%)
		leucine-rich repeat	349..372	CDD:275380	3/22 (14%)
		PP2Cc	461..655	CDD:294085	47/234 (20%)
Adcy7	XP_006530643.1	AC_N	<75..251	CDD:318454	24/101 (24%)
		Guanylate_cyc	272..422	CDD:306677	33/204 (16%)
		DUF1053	487..593	CDD:399378	25/119 (21%)
		Guanylate_cyc	890..1085	CDD:306677
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900