DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Phlpp and ADCY9

DIOPT Version :9

Sequence 1:NP_001260558.1 Gene:Phlpp / 35178 FlyBaseID:FBgn0032749 Length:954 Species:Drosophila melanogaster
Sequence 2:XP_005255136.1 Gene:ADCY9 / 115 HGNCID:240 Length:1372 Species:Homo sapiens


Alignment Length:711 Identity:125/711 - (17%)
Similarity:233/711 - (32%) Gaps:197/711 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly   100 KLMELIINGTNLQTLVADHNYLHNISTTNTHPVPLKLQRIDISHNNFSELPNWVGACASLTAIN- 163
            |:.:.|::|.:|:...|       :.....|.|..::...|:......|..|.|...|:.:..| 
Human   312 KVGQSIMHGKDLEVEKA-------LKERMIHSVMPRIIADDLMKQGDEESENSVKRHATSSPKNR 369

  Fly   164 ASHNRLNNVAVLLRNYRITELVSLDLAYNDLKQLDQFPEGFSSIRSLQLQSNELPSLPDNFFAVT 228
            ...:.:....:..|.:::.::..:.:.:.|:       .||:.: |....::.|..|.::.|   
Human   370 KKKSSIQKAPIAFRPFKMQQIEEVSILFADI-------VGFTKM-SANKSAHALVGLLNDLF--- 423

  Fly   229 HARLETL--NVSCNKLSTL------------PRYEQNNHA-ALVNLSLAGNHLNDSIFEPLHNAA 278
             .|.:.|  ...|.|:|||            ||.:   || ..:.:.|......:...:......
Human   424 -GRFDRLCEETKCEKISTLGDCYYCVAGCPEPRAD---HAYCCIEMGLGMIKAIEQFCQEKKEMV 484

  Fly   279 KLRV-LHLAYNRIGVLPAACVRNWPELEILVLSGNM-LQQLPEEVATLGQLRVLRCCNNLLLCTP 341
            .:|| :|......|:|      .....:..|.|.:: |..|.|::...|::.:..          
Human   485 NMRVGVHTGTVLCGIL------GMRRFKFDVWSNDVNLANLMEQLGVAGKVHISE---------- 533

  Fly   342 QLAKLAMLKVLDLSHNHLDRVNLLALVPS------RNLKYLDLSGNLQLQVDEQQFKVCQSQSQR 400
                 |..|.||..:...|...:..|..|      :.||...:||    |..::....|......
Human   534 -----ATAKYLDDRYEMEDGKVIERLGQSVVADQLKGLKTYLISG----QRAKESRCSCAEALLS 589

  Fly   401 HWSLVD--------------VSGN------------NRAALPTTKI-----RQVSAQ-------- 426
            .:.::|              .|||            |....|:..|     .:..|:        
Human   590 GFEVIDGSQVSSGPRGQGTASSGNVSDLAQTVKTFDNLKTCPSCGITFAPKSEAGAEGGAPQNGC 654

  Fly   427 ----RNQNKTSGPWTMGFAETPGSGDCRKLSVYQLRAANYGG-------------SDEAL----Y 470
                :|..|.:..|.: |...|       |..:..:|:  ||             .:|.|    .
Human   655 QDEHKNSTKVTSSWLL-FLSVP-------LLAHPPKAS--GGPNPKTQNGLLSPPQEEKLTNSQT 709

  Fly   471 GMFEALEGRGR---AAQEMSHLVP---------------DLMKQEQMVKDSAVRDYM------KF 511
            .:.|.|:.:||   .:.:.|.|:|               |::|:     ||.::||.      :|
Human   710 SLCEILQEKGRWAGVSLDQSALLPLRFKNIREKTDAHFVDVIKE-----DSLMKDYFFKPPINQF 769

  Fly   512 TLLAAQQQCGSVRSAALFHLTRTRAPSKVRPLKSKRYVLRMASTGGLDAYLIRRTSQLRLTKPDV 576
            :|....|:.  .||....:.......|.|:...|..:      :..||.:| ..|..|.|:....
Human   770 SLNFLDQEL--ERSYRTSYQEEVIKNSPVKTFASPTF------SSLLDVFL-STTVFLTLSTTCF 825

  Fly   577 IQKDQIHSMPDPHVLELILSNDDEYLVVGNAQLWSVMDIDRAAREIRKEENSLLAAKRLVDIAQS 641
            ::.:.....|.|..|          .|...|.|..|:.:..:.|.:...|:.:...|||::....
Human   826 LKYEAATVPPPPAAL----------AVFSAALLLEVLSLAVSIRMVFFLEDVMACTKRLLEWIAG 880

  Fly   642 FAAAESLSVIVVRFRHLGTDVDHLIRELKQSVRKKPQPVSLPLSSGSVCKRTCCDRSNACR 702
            :.....:..|:|....|.. ..|:..|.:.::.       .|:.:||..........|.|:
Human   881 WLPRHCIGAILVSLPALAV-YSHVTSEYETNIH-------FPVFTGSAALIAVVHYCNFCQ 933

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PhlppNP_001260558.1 leucine-rich repeat 91..110 CDD:275380 3/9 (33%)
LRR_8 109..169 CDD:290566 10/60 (17%)
leucine-rich repeat 111..135 CDD:275380 4/23 (17%)
leucine-rich repeat 136..158 CDD:275380 4/21 (19%)
leucine-rich repeat 159..183 CDD:275380 2/24 (8%)
leucine-rich repeat 184..209 CDD:275380 3/24 (13%)
LRR_8 205..266 CDD:290566 16/75 (21%)
leucine-rich repeat 210..230 CDD:275380 3/19 (16%)
leucine-rich repeat 232..255 CDD:275380 10/37 (27%)
LRR_RI <256..410 CDD:238064 27/175 (15%)
leucine-rich repeat 256..276 CDD:275380 1/19 (5%)
LRR_8 279..359 CDD:290566 15/81 (19%)
leucine-rich repeat 280..303 CDD:275380 5/23 (22%)
leucine-rich repeat 304..348 CDD:275380 6/44 (14%)
leucine-rich repeat 349..372 CDD:275380 6/28 (21%)
PP2Cc 461..655 CDD:294085 45/234 (19%)
ADCY9XP_005255136.1 DUF2339 <118..>301 CDD:287113
CYCc 326..544 CDD:214485 44/260 (17%)
Guanylate_cyc 385..573 CDD:278633 39/223 (17%)
CYCc 1043..1243 CDD:214485
Guanylate_cyc 1069..1260 CDD:278633
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2114
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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